CAY10499

Product Name: CAY10499
CAS No.: 359714-55-9
Chemical Name: CAY10499
Synonyms: CAY10499;CAY10499 Exclusive;QTENHWTVRQKWRI-UHFFFAOYSA-N;Inhibitor,inhibit,MAGLIN5,MAGL IN 5,FAAH,Fatty acid amide hydrolase,Monoacylglycerol lipase,MAGL;Carbamic acid, N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-, phenylmethyl ester
CBNumber: CB62590413
Molecular Formula: C18H17N3O5
Formula Weight: 355.34
MOL File: 359714-55-9.mol

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CAY10499 Property

Density: 1.31±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO
form: crystalline solid
pka: 13.31±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10007875
Product name: CAY10499
Purity: ≥98%
Packaging: 1mg
Price: $16
Updated: 2024/03/01

Cayman Chemical

Product number: 10007875
Product name: CAY10499
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 10007875
Product name: CAY10499
Purity: ≥98%
Packaging: 10mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 10007875
Product name: CAY10499
Purity: ≥98%
Packaging: 25mg
Price: $235
Updated: 2024/03/01

ApexBio Technology

Product number: B7841
Product name: CAY10499
Packaging: 10mg
Price: $154
Updated: 2021/12/16

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CAY10499 Chemical Properties,Usage,Production

Description

CAY10499 is a non-selective lipase inhibitor (IC₅₀s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). It also inhibits ATGL, DAGLa, ABHD6, and CES1 by 95, 60, 90, and 95%, respectively, when used at a concentration of 5 mM. CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC₅₀s = 4.2, 46, 106.7, and 79.8 μM, respectively). In vivo, CAY10499 reduces FRUC diet- and AIN-93M diet-induced increases in cytosolic lipase activity in rats.

Definition

ChEBI: CAY10499 is a carbamate ester.

References

[1] muccioli g g, labar g, lambert d m. cay10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious mgl assay[j]. chembiochem, 2008, 9(16): 2704-2710.
[2] ben ali y, muller g, petry s, et al. kinetic characterization and specific inhibition of hormone sensitive lipase[c]//chemistry and physics of lipids. elsevier house, brookvale plaza, east park shannon, co, clare, 00000, ireland: elsevier ireland ltd, 2005, 136(2): 155-155.
[3] kraemer f b, shen w j. hormone-sensitive lipase control of intracellular tri-(di-) acylglycerol and cholesteryl ester hydrolysis[j]. journal of lipid research, 2002, 43(10): 1585-1594.

CAY10499 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10499 Suppliers

CHINA 27 United States 5 Global 32

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359714-55-9, CAY10499Related Search:

CAY10499

QTENHWTVRQKWRI-UHFFFAOYSA-N

CAY10499 Exclusive

Inhibitor,inhibit,MAGLIN5,MAGL IN 5,FAAH,Fatty acid amide hydrolase,Monoacylglycerol lipase,MAGL

Carbamic acid, N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-, phenylmethyl ester

359714-55-9