CAY10499
- Product Name
- CAY10499
- CAS No.
- 359714-55-9
- Chemical Name
- CAY10499
- Synonyms
- CAY10499;CAY10499 Exclusive;QTENHWTVRQKWRI-UHFFFAOYSA-N;Benzyl (4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl)carbamate;Inhibitor,inhibit,MAGLIN5,MAGL IN 5,FAAH,Fatty acid amide hydrolase,Monoacylglycerol lipase,MAGL;Carbamic acid, N-[4-(5-methoxy-2-oxo-1,3,4-oxadiazol-3(2H)-yl)-2-methylphenyl]-, phenylmethyl ester
- CBNumber
- CB62590413
- Molecular Formula
- C18H17N3O5
- Formula Weight
- 355.34
- MOL File
- 359714-55-9.mol
CAY10499 Property
- Density
- 1.31±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 13.31±0.70(Predicted)
- color
- Off-white to yellow
N-Bromosuccinimide Price
- Product number
- 10007875
- Product name
- CAY10499
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $16
- Updated
- 2024/03/01
- Product number
- 10007875
- Product name
- CAY10499
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 10007875
- Product name
- CAY10499
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 10007875
- Product name
- CAY10499
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $235
- Updated
- 2024/03/01
- Product number
- B7841
- Product name
- CAY10499
- Packaging
- 10mg
- Price
- $154
- Updated
- 2021/12/16
CAY10499 Chemical Properties,Usage,Production
Description
CAY10499 is a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). It also inhibits ATGL, DAGLa, ABHD6, and CES1 by 95, 60, 90, and 95%, respectively, when used at a concentration of 5 mM. CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 μM, respectively). In vivo, CAY10499 reduces FRUC diet- and AIN-93M diet-induced increases in cytosolic lipase activity in rats.
Definition
ChEBI: CAY10499 is a carbamate ester.
References
[1] muccioli g g, labar g, lambert d m. cay10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious mgl assay[j]. chembiochem, 2008, 9(16): 2704-2710.
[2] ben ali y, muller g, petry s, et al. kinetic characterization and specific inhibition of hormone sensitive lipase[c]//chemistry and physics of lipids. elsevier house, brookvale plaza, east park shannon, co, clare, 00000, ireland: elsevier ireland ltd, 2005, 136(2): 155-155.
[3] kraemer f b, shen w j. hormone-sensitive lipase control of intracellular tri-(di-) acylglycerol and cholesteryl ester hydrolysis[j]. journal of lipid research, 2002, 43(10): 1585-1594.
CAY10499 Preparation Products And Raw materials
Raw materials
Preparation Products
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