ChemicalBook > CAS DataBase List > CAY10650

CAY10650

Product Name
CAY10650
CAS No.
1233706-88-1
Chemical Name
CAY10650
Synonyms
CS-1520;CAY10650;CAY10650, >=98%;CAY 10650;CAY-10650;CAY10650, 10 mM in DMSO;CAY10650;CAY-10650;CAY 10650;3-isobutanoyl-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]indole-5-carboxylic acid;3-isobutyryl-1-(2-oxo-3-(4-phenoxyphenoxy)propyl)-1H-indole-5-carboxylic acid;3-(2-methylpropanoyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid;3-(2-Methyl-1-oxopropyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
CBNumber
CB62590453
Molecular Formula
C28H25NO6
Formula Weight
471.5
MOL File
1233706-88-1.mol
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CAY10650 Property

Melting point:
103-104℃
Boiling point:
685.4±55.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
pka
4.03±0.30(Predicted)
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10743
Product name
CAY10650
Purity
≥98%
Packaging
1mg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
10743
Product name
CAY10650
Purity
≥98%
Packaging
5mg
Price
$286
Updated
2024/03/01
Cayman Chemical
Product number
10743
Product name
CAY10650
Purity
≥98%
Packaging
10mg
Price
$505
Updated
2024/03/01
Cayman Chemical
Product number
10743
Product name
CAY10650
Purity
≥98%
Packaging
50mg
Price
$2207
Updated
2024/03/01
ChemScene
Product number
CS-2024
Product name
CAY10650
Purity
>98.0%
Packaging
1mg
Price
$60
Updated
2021/12/16
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CAY10650 Chemical Properties,Usage,Production

Description

Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor. It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. The phase I metabolite of this compound, CAY10641 , is also available.

Uses

CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion[1][2].

in vivo

CAY10650 (50 μg/5 μL; Inject with topical eye-drop; Chinese hamsters) relieves acanthamoeba keratitis in vivo.[1].

Animal Model:Chinese hamsters with infected with parasite-laden contact lenses[1]
Dosage:50 μg/5 μL
Administration:Inject with topical eye-drop under the contact lens; three times a day for 6 days and topically on days 7 to 20 postinfection
Result:Reduced the severity of the keratitis and hasten the onset of resolution.
Had little mild inflammation and very few PMNs infiltration in the corneal stroma.

References

[1] Paloschi MV, et, al. Cytosolic phospholipase A2-α participates in lipid body formation and PGE2 release in human neutrophils stimulated with an L-amino acid oxidase from Calloselasma rhodostoma venom. Sci Rep. 2020 Jul 3;10(1):10976. DOI:10.1038/s41598-020-67345-3
[2] Tripathi T, et, al. Role of phospholipase A (PLA) inhibitors in attenuating apoptosis of the corneal epithelial cells and mitigation of Acanthamoeba keratitis. Exp Eye Res. 2013 Aug;113:182-91. DOI:10.1016/j.exer.2013.05.021

CAY10650 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10650 Suppliers

China 68 United States 10 Global 78
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39999
Advantage
60
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58

1233706-88-1, CAY10650Related Search:


  • CAY10650
  • 1H-Indole-5-carboxylic acid, 3-(2-Methyl-1-oxopropyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-
  • 3-(2-Methyl-1-oxopropyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
  • CAY10650, >=98%
  • CAY 10650;CAY-10650
  • CAY10650;CAY-10650;CAY 10650
  • CS-1520
  • 3-isobutanoyl-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]indole-5-carboxylic acid
  • 3-isobutyryl-1-(2-oxo-3-(4-phenoxyphenoxy)propyl)-1H-indole-5-carboxylic acid
  • acanthamoeba,inhibit,CAY 10650,PGE2,CAY10650,lipid droplets,neutrophils,keratitis,mannose-induced protein,corneal epithelial cells,CAY-10650,Inhibitor,Phospholipase
  • 3-(2-methylpropanoyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
  • CAY10650, 10 mM in DMSO
  • 1233706-88-1