tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate

Product Name: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate
CAS No.: 1181267-36-6
Chemical Name: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate
Synonyms: Erastin impurity 2;Bilastine Impurity 02;Bilastine Boc Impurity;Bilastine Boc Impurity 32;N-Boc 1-(2-Ethyoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole;tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)pip...;4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate;ert-butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate;tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate;4-[1-(2-Ethoxy-ethyl)-1H-benzoimidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
CBNumber: CB62594138
Molecular Formula: C21H31N3O3
Formula Weight: 373.49
MOL File: 1181267-36-6.mol

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tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Property

Boiling point:: 521.7±45.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.31±0.10(Predicted)
InChI: InChI=1S/C21H31N3O3/c1-5-26-15-14-24-18-9-7-6-8-17(18)22-19(24)16-10-12-23(13-11-16)20(25)27-21(2,3)4/h6-9,16H,5,10-15H2,1-4H3
InChIKey: WLBGIVZZFISEJL-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C2N(CCOCC)C3=CC=CC=C3N=2)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B619400
Product name: N-Boc1-(2-Ethyoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole
Packaging: 100mg
Price: $1055
Updated: 2021/12/16

AK Scientific

Product number: Z3424
Product name: tert-Butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
Packaging: 25g
Price: $192
Updated: 2021/12/16

Chemenu

Product number: CM161857
Product name: tert-butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
Purity: 95%
Packaging: 5g
Price: $122
Updated: 2021/12/16

Abosyn

Product number: 21-1607
Product name: tert-butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
Purity: 95%-98%
Packaging: 5g
Price: $180
Updated: 2021/12/16

Chemenu

Product number: CM161857
Product name: tert-butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate
Purity: 95%
Packaging: 10g
Price: $194
Updated: 2021/12/16

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tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

N-Boc 1-(2-Ethyoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole is an impurity of Bilastine (B385000), which is a novel, nonsedating H1-antihistamine developed for symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria.

Synthesis

628-34-2

953071-73-3

1181267-36-6

To a reaction flask was added 38.00 g of 1-chloro-2-ethoxyethane (Compound 4, 0.35 mol) and 90.4 g of tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (Compound 3, 0.3 mol). Under cooling in an ice bath, 7 mL of polyethylene glycol-400 (containing 0.25 mol NaOH and 0.1 mol Na2CO3) was slowly added, and the reaction mixture was stirred vigorously at 40 °C for 2 hours. After completion of the reaction, the reaction solution was cooled to room temperature, extracted with ether, and the organic phase was washed with saturated brine, dried over anhydrous sodium sulfate and filtered. The solvent was removed by distillation under reduced pressure to give 103.1 g tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (compound 5) in 92% yield.

References

[1] Synthetic Communications, 2011, vol. 41, # 9, p. 1394 - 1402
[2] Patent: CN106146459, 2016, A. Location in patent: Paragraph 0055; 0056; 0057; 0058; 0059; 0060
[3] Patent: WO2014/188453, 2014, A2. Location in patent: Page/Page column 29

tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Suppliers

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View Lastest Price from tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate 1181267-36-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-28

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Bilastine Impurity 19 1181267-36-6
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-28

Shaanxi Dideu New Materials Co. Ltd

Product: tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate 1181267-36-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000KGS
Release date: 2025-02-18

1181267-36-6, tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylateRelated Search:

tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Bilastine N-Oxide 1'-Hydroxy Bilastine Bilastine

tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate

4-[1-(2-Ethoxyethyl)-1H-benzimidazol-2-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

N-Boc 1-(2-Ethyoxyethyl)-2-(4-piperidinyl)-1H-benzimidazole

4-[1-(2-Ethoxy-ethyl)-1H-benzoimidazol-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

4-(1-(2-ethoxyethyl)-1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-[1-(2-ethoxyethyl)-1H-benzimidazol-2-yl]-, 1,1-dimethylethyl ester

tert-butyl 4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)pip...

Bilastine Boc Impurity

ert-butyl4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate

Bilastine ITS-1 tert-butyl 4-(1-(2-ethoxyethyl)-1Hbenzo[d]iMidazol-2-yl)piperidine-1-carboxylate

Erastin impurity 2

Bilastine Boc Impurity 32

Bilastine Impurity 02

1181267-36-6

181267-36-6

C21H31N3O3