ChemicalBook > CAS DataBase List > 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
- Product Name
- 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
- CAS No.
- 1235318-89-4
- Chemical Name
- 2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-
- Synonyms
- ADX88178;ADX-88178;ADX88178, >98%;ADX-88178;ADX 88178;ADX88178;4-methyl-N-[5-methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-2-Pyrimidinamine;5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine;2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]-;5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine;Inhibitor,ADX 88178,mGluR,ADX88178,Metabotropic glutamate receptors,inhibit,ADX-88178
- CBNumber
- CB62594800
- Molecular Formula
- C12H12N6S
- Formula Weight
- 272.33
- MOL File
- 1235318-89-4.mol
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2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:16.67(Max Conc. mg/mL);61.21(Max Conc. mM)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-6961
- Product name
- ADX88178
- Purity
- 99.60%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6961
- Product name
- ADX88178
- Purity
- 99.60%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC10465
- Product name
- ADX-88178
- Purity
- >98%
- Packaging
- 1g
- Price
- $1600
- Updated
- 2021/12/16
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2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Chemical Properties,Usage,Production
Description
ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.
target
ADX88178 is a metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4.
2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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2-PyriMidinaMine,4-Methyl-N-[5-Methyl-4-(1H-pyrazol-4-yl)-2-thiazolyl]- Suppliers
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