ChemicalBook > CAS DataBase List > Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl ester

Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl ester

Product Name
Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl ester
CAS No.
203663-25-6
Chemical Name
Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl ester
Synonyms
2-Boc-octahydrocyclopenta[c]pyrrol-5-ol;tert-butyl 5-hydroxy-octahydrocyclopenta[c]pyrrole-2-carboxylate;tert-butyl 5-hydroxy-hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate;5-Hydroxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester;tert-butyl 5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate;Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl ester
CBNumber
CB62603931
Molecular Formula
C12H21NO3
Formula Weight
227.3
MOL File
203663-25-6.mol
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Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl ester Property

storage temp. 
2-8°C
Appearance
White to off-white Solid
InChI
InChI=1S/C12H21NO3/c1-12(2,3)16-11(15)13-6-8-4-10(14)5-9(8)7-13/h8-10,14H,4-7H2,1-3H3
InChIKey
DIDQRACXWWEPDZ-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC2CC(O)CC2C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B943540
Product name
tert-Butyl5-Hydroxy-hexahydrocyclopenta[C]pyrrole-2(1h)-carboxylate
Packaging
100mg
Price
$200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM1554717
Product name
TERT-BUTYL-5-HYDROXY-OCTAHYDROCYCLOPENTA[C]PYRROLE-2-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$451.44
Updated
2021/12/16
Ambeed
Product number
A168950
Product name
tert-Butyl5-hydroxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Purity
95%
Packaging
100mg
Price
$70
Updated
2021/12/16
Ambeed
Product number
A168950
Product name
tert-Butyl5-hydroxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Purity
95%
Packaging
250mg
Price
$110
Updated
2021/12/16
Ambeed
Product number
A168950
Product name
tert-Butyl5-hydroxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Purity
95%
Packaging
1g
Price
$230
Updated
2021/12/16
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Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl ester Chemical Properties,Usage,Production

Synthesis

148404-28-8

203663-25-6

Step 4) 2-(tert-butoxycarbonyl)hexahydrocyclopenta[c]pyrrol-5(1H)-one (0.9 g, 4 mmol) was dissolved in EtOH (20 mL), and NaBH4 (0.82 g, 21.7 mmol) was added in batches. The reaction mixture was stirred at room temperature for 4.5 h and then concentrated under vacuum. The residue was diluted with EtOAc (50 mL) and washed sequentially with H2O (50 mL) and brine (50 mL). The resulting organic phase was dried over anhydrous Na2SO4 and concentrated in vacuum to afford tert-butyl 5-hydroxy-hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate as a yellow oil (0.99 g, 100% yield), which was used directly in the subsequent reaction.

References

[1] Patent: WO2013/138210, 2013, A1. Location in patent: Paragraph 0296
[2] Patent: WO2018/133858, 2018, A1. Location in patent: Paragraph 00207
[3] Patent: EP3401315, 2018, A1. Location in patent: Paragraph 0157; 0161
[4] Patent: US6518423, 2003, B1
[5] Chemical Biology and Drug Design, 2012, vol. 80, # 3, p. 388 - 397

Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl ester Suppliers

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203663-25-6, Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl esterRelated Search:

1,2,3,4-Cyclobutanetetracarboxylic Dianhydride Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, 5-aminohexahydro-, 1,1-dimethylethyl ester, ethanedioate (1:1), (3aR,6aS)-rel- Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-dimethylethyl ester, (3aα,5α,6aα) Cyclopentyl isocyanate cyclohex-1,4-ylene diisocyanate

  • Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-hydroxy-, 1,1-diMethylethyl ester
  • tert-butyl 5-hydroxy-hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
  • tert-butyl 5-hydroxy-octahydrocyclopenta[c]pyrrole-2-carboxylate
  • 5-Hydroxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester
  • tert-butyl 5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate
  • 2-Boc-octahydrocyclopenta[c]pyrrol-5-ol
  • 203663-25-6