Heterophyllin B
- Product Name
- Heterophyllin B
- CAS No.
- 145459-19-4
- Chemical Name
- Heterophyllin B
- Synonyms
- Heterophylin B;Heterophyllin B;Prince Ginseng Cyclic Peptide B;Cyclo(glycylglycyl-L-leucyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-phenylalanyl);Cyclo(glycylglycyl-L-isoleucyl-L-prolyl-L-prolyl-L-prolyl-L-isole ucyl-L-phenylalanyl);(6S,15S,18S,20aS,25aS,30aS)-15-Benzyl-18-((S)-sec-butyl)-6-isobutylicosahydro-1H,25H-tripyrrolo[1,2-a:1',2'-d:1'',2''-g][1,4,7,10,13,16,19,22]octaazacyclotetracosin-5,8,11,14,17,20,25,30(30aH)-octaone;(6S,15S,18S,20aS,25aS,30aS)-15-Benzyl-18-((S)-sec-butyl)-6-isobutylicosahydro-1H,25H-tripyrrolo[1,2-a:1',2'-d:1'',2''-g][1,4,7,10,13,16,19,22]octaazacyclotetracosin-5,8,11,14,17,20,25,30(30aH)-octaone
- CBNumber
- CB62604877
- Molecular Formula
- C40H58N8O8
- Formula Weight
- 778.94
- MOL File
- 145459-19-4.mol
Heterophyllin B Property
- Boiling point:
- 1159.7±65.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in DMSO
- pka
- 13.44±0.70(Predicted)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 300415
- Product name
- Heterophyllin B
- Packaging
- 20mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- CS-0016982
- Product name
- HeterophyllinB
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- CS-0016982
- Product name
- HeterophyllinB
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- orb594002
- Product name
- Heterophyllin B
- Packaging
- 20mg
- Price
- $391
- Updated
- 2021/12/16
- Product number
- orb105560
- Product name
- Heterophyllin B
- Purity
- >98%
- Packaging
- 20mg
- Price
- $569.5
- Updated
- 2021/12/16
Heterophyllin B Chemical Properties,Usage,Production
Chemical Properties
White crystal, easily soluble in methanol, derived from Radix Radix.
Uses
Taizishencyclopeptide B has the functions of invigorating qi and blood, invigorating body fluid and invigorating the spleen and stomach. And it was used for content determination/identification/pharmacological experiments, etc.
Biological Activity
Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. It can be used in esophageal cancer research.
in vitro
Heterophyllin B (0-200 μM; 12-48 hours) reduces cell viability in the 75, 100 and 200 μM groups, has no effect on 5, 10, 25 and 50 μM groups.Heterophyllin B (0 -50 μM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells.
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Cell Viability Assay
Cell Line: | ECA-109 cells |
Concentration: | 5 μM, 10 μM, 25 μM, 50 μM, 75 μM, 100 μM and 200 μM |
Incubation Time: | 12, 24 and 48 hours |
Result: | Decrease cell viability at high concentrations. |
Western Blot Analysis
Cell Line: | ECA-109 cells |
Concentration: td> | 0 μM, 10 μM, 25 μM, 50 μM |
Incubation Time: | 6 hours |
Result: | Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin. |
Heterophyllin B Preparation Products And Raw materials
Raw materials
Preparation Products
Heterophyllin B Suppliers
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View Lastest Price from Heterophyllin B manufacturers
- Product
- Heterophyllin B 145459-19-4
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-12-12
- Product
- Heterophyllin B 145459-19-4
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg , 5kg, 50kg
- Release date
- 2020-01-17