DIPROTIN A

Product Name: DIPROTIN A
CAS No.: 90614-48-5
Chemical Name: DIPROTIN A
Synonyms: Diprotin;DIPROTIN A;ILE-PRO-ILE;Ile-Pro-Ile-OH;DIPROTIN A H2O;ILE-PRO-ILE H2O;H-ILE-PRO-ILE-OH;H-ILE-PRO-ILE-OH H2O;L-Ile-L-Pro-L-Ile-OH;Diprotin A (Ile-Pro-Ile)
CBNumber: CB6261540
Molecular Formula: C17H31N3O4
Formula Weight: 341.45
MOL File: 90614-48-5.mol

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DIPROTIN A Property

Boiling point:: 583.1±50.0 °C(Predicted)
Density: 1.140±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO:250.0(Max Conc. mg/mL);732.17(Max Conc. mM)
Water:67.08(Max Conc. mg/mL);196.44(Max Conc. mM)
pka: 3.72±0.22(Predicted)
form: White to off-white solid.
color: White to off-white
Water Solubility: Soluble in water at 1mg/ml
CAS DataBase Reference: 90614-48-5(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: NR4737000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I9759
Product name: Ile-Pro-Ile
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $171
Updated: 2025/07/31

Sigma-Aldrich

Product number: I9759
Product name: Ile-Pro-Ile
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $387
Updated: 2025/07/31

TCI Chemical

Product number: D6199
Product name: Diprotin A
Packaging: 50MG
Price: $177
Updated: 2025/07/31

Cayman Chemical

Product number: 28014
Product name: Diprotin A
Packaging: 10mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 28014
Product name: Diprotin A
Packaging: 25mg
Price: $90
Updated: 2024/03/01

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DIPROTIN A Chemical Properties,Usage,Production

Uses

Ile-Pro-Ile has been used as a supplement for blood collection for hormone measurement and used in Islets cell culture to stabilize glucagon-like peptide-1 (GLP-1). It has also been used to inhibit the breakdown of gonadotropin-inhibitory hormone (GnIH) following serum collection.

Uses

As New dipeptidyl peptidase IV inhibitors (Diprotin A) and their uses as anti-cancer agents

Definition

ChEBI: (2S,3S)-2-[[[(2S)-1-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-methylpentanoic acid is a peptide.

Biochem/physiol Actions

Inhibitor of dipeptidyl peptidase IV. Inhibits entry of HIV-1 or HIV-2 into T lymphoblastoid and monocytoid cell lines.

in vivo

Diprotin A (intraperitoneal injection; 70?μg/kg; twice daily; 7 days) increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway^[1].

Animal Model:	Streptozotocin-induced diabetic retinopathy model in wild-type C57/BL6 mice^[1]
Dosage:	70?μg/kg
Administration:	Intraperitoneal injection; twice daily; 7 days
Result:	Induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.

IC 50

DPP-4

storage

Store at -20°C

DIPROTIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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DIPROTIN A Suppliers

Canada 1 China 103 Germany 3 India 1 Japan 2 Switzerland 3 United Kingdom 4 United States 18 Global 135

Alabiotech Inc.

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TargetMol Chemicals Inc.

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BOC Sciences

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Abcam Limited

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Cayman Chemical Company

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Creative Enzymes

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MedChemExpress

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Riedel-de Haen AG

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Medical Isotopes

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Advance Scientific & Chemical

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3B Scientific Corporation

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MP Biomedicals, Inc.

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SynPep Corporation

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Chem-Impex International, Inc.

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EMD Biosciences, Inc.

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Spectrum Chemicals & Laboratory Products

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Crescent Chemical Co., Inc.

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90614-48-5, DIPROTIN ARelated Search:

DIPROTIN B 1-Butylpyrrolidine 1-(2-Aminoethyl)pyrrolidine 2-(Aminomethyl)-1-ethylpyrrolidine DL-Isoleucine DIPROTIN A DIPEPTIDYLPEPTIDASE IV GLYCINE-NME2 ACETATE (1-ETHYLPYRROLIDIN-2-YL)-N-METHYLMETHANAMINE (S)-2-AMINO-3-METHYL-1-(PYRROLIDIN-1-YL)BUTAN-1-ONE CNTSVITQACPKISFEPIPI H-PRO-VAL-OH H-ALA-PRO-GLY-OH H-PRO-ALA-OH H-GLY-PRO-GLY-OH H-GLY-PRO-ALA-OH H-ALA-PRO-ALA-OH H-PRO-ILE-OH

n-(1-l-isoleucyl-l-prolyl)-l-isoleucin

n-(1-l-isoleucyl-l-prolyl)-l-isoleucine

DIPROTIN A

DIPROTIN A H2O

DIPEPTIDYLPEPTIDASE IV INHIBITOR I

ILE-PRO-ILE

ILE-PRO-ILE H2O

H-ILE-PRO-ILE-OH

H-ILE-PRO-ILE-OH H2O

L-Isoleucyl-L-prolyl-L-isoleucine

Ile-Pro-Ile-OH

L-Ile-L-Pro-L-Ile-OH

N-(N-L-Isoleucyl-L-prolyl)-L-isoleucine

L-Isoleucine, N-(1-L-isoleucyl-L-prolyl)-

ILE-PRO-ILE;L-ISOLEUCYL-L-PROLYL-L-ISOLEUCINE

L-Isoleucine, L-isoleucyl-L-prolyl-

Diprotin A (Ile-Pro-Ile)

Diprotin

Diprotin A,H/R condition,vascular leakage,Diabetic retinopathy,normoxia,Inhibitor,endothelial cell,inhibit,DPP,hECs,Dipeptidyl Peptidase

(2S,3S)-2-((S)-1-((2S,3S)-2-Amino-3-methylpentanoyl)pyrrolidine-2-carboxamido)-3-methylpentanoic acid

Diprotin A, Dipeptidyl peptidase IV inhibitor

Diprotin A, 10 mM in DMSO

90614-48-5

C17H31N3O4

Immune Cell Signaling and Blood

Immune System Regulation

BioChemical

AIDS and Viral Research Reagents

Cell Signaling and Neuroscience

Cell Biology

Chiral Reagents

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Pepetides

peptides