5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate
- Product Name
- 5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate
- CAS No.
- 52248-03-0
- Chemical Name
- 5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate
- Synonyms
- VHPOFDUCFKOUHV-XKGORWRGSA-O;S-(5'-Adenosyl)-L-methionine tosylate;S-(5''-Adenosyl)-L-methionine tosylate;P-toluenesulfonic acid adenosylmethionine;S-Adenosyl-L-Methionine p-Toluenesulfonic acid;P-toluenesulfonic acid adenosylmethionine (SAMe);S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt;S-(5''-Adenosyl)-L-methionine tosylate, 10 mM in DMSO;S-(5′-Adenosyl)-
L -methionine p-toluenesulfonate salt;5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate - CBNumber
- CB62616975
- Molecular Formula
- C22H30N6O8S2
- Formula Weight
- 570.64
- MOL File
- 52248-03-0.mol
5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate Property
- Melting point:
- 78℃
- storage temp.
- -20°C
- solubility
- DMF: 5 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- color
- White to yellow
- biological source
- synthetic (Organic)
- Water Solubility
- H2O: 100mg/mL
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A2408
- Product name
- S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt
- Purity
- ≥80% (HPLC), ≥80% (spectrophotometric assay)
- Packaging
- 25mg
- Price
- $101
- Updated
- 2025/07/31
- Product number
- A2408
- Product name
- S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt
- Purity
- ≥80% (HPLC), ≥80% (spectrophotometric assay)
- Packaging
- 100mg
- Price
- $206
- Updated
- 2025/07/31
- Product number
- 16376
- Product name
- S-(5''-Adenosyl)-L-methionine (tosylate)
- Packaging
- 50mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 16376
- Product name
- S-(5'-Adenosyl)-L-methionine (tosylate)
- Packaging
- 500mg
- Price
- $632
- Updated
- 2024/03/01
- Product number
- A2408
- Product name
- S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt
- Purity
- ≥80% (HPLC), ≥80% (spectrophotometric assay)
- Packaging
- 500mg
- Price
- $712
- Updated
- 2025/07/31
5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate Chemical Properties,Usage,Production
Uses
S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt has been used for cell proliferation assay. It has also been used for methylation assay.
General Description
S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt is used for the treatment of depression, liver cirrhosis, cholestasis and degenerative joint disease.
Biochem/physiol Actions
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
in vivo
Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC).? However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC[3].
IC 50
Human Endogenous Metabolite
5'-[[(3S)-3-AMino-3-carboxypropyl]Methylsulfonio]-5'-deoxy-Adenosine tosylate Preparation Products And Raw materials
Raw materials
Preparation Products
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