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Pyridine, 3-(4,5-dihydro-2-oxazolyl)-

Product Name
Pyridine, 3-(4,5-dihydro-2-oxazolyl)-
CAS No.
40055-37-6
Chemical Name
Pyridine, 3-(4,5-dihydro-2-oxazolyl)-
Synonyms
Nicorandil Impurity 3;Nicodil EP impuritiy 1;Nicorandil EP Impurity 4;Nicorandil EP Impurity D;2-(3-Pyridyl)-2-oxazoline;2-Pyridin-3-yl-2-oxazoline;2-(Pyridin-3-yl)-4,5-dihydrooxazole;Pyridine, 3-(4,5-dihydro-2-oxazolyl)-;2-pyridin-3-yl-4,5-dihydro-1,3-oxazole;Nicorandil Impurity 4(Nicorandil EP Impurity D)
CBNumber
CB62617013
Molecular Formula
C8H8N2O
Formula Weight
148.16
MOL File
40055-37-6.mol
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Pyridine, 3-(4,5-dihydro-2-oxazolyl)- Property

Melting point:
71 °C
Boiling point:
260 °C
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
4.13±0.12(Predicted)
color 
Off-White to Pale Yellow
Stability:
Hygroscopic
InChI
InChI=1S/C8H8N2O/c1-2-7(6-9-3-1)8-10-4-5-11-8/h1-3,6H,4-5H2
InChIKey
FVASBRDDSBRETH-UHFFFAOYSA-N
SMILES
C1=NC=CC=C1C1=NCCO1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BP1106
Product name
Nicorandil amide
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
10MG
Price
$218
Updated
2025/07/31
TRC
Product number
P995715
Product name
2-(3-Pyridyl)-2-oxazoline
Packaging
500mg
Price
$165
Updated
2021/12/16
AK Scientific
Product number
6961CD
Product name
2-(Pyridin-3-yl)-4,5-dihydrooxazole
Packaging
100mg
Price
$190
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0025962
Product name
2-(3-PYRIDYL)-2-OXAZOLINE
Purity
95.00%
Packaging
5MG
Price
$499.35
Updated
2021/12/16
Ambeed
Product number
A220351
Product name
2-(Pyridin-3-yl)-4,5-dihydrooxazole
Purity
97%
Packaging
5g
Price
$1328
Updated
2021/12/16
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Pyridine, 3-(4,5-dihydro-2-oxazolyl)- Chemical Properties,Usage,Production

Uses

2-(3-Pyridyl)-2-oxazoline is an impurity of Nicorandil (N398500). Nicorandil impurity E.

Synthesis

500-22-1

141-43-5

40055-37-6

General procedure for the synthesis of 3-(4,5-dihydro-2-oxazolyl)-pyridine from 3-pyridinecarboxaldehyde and 2-aminoethanol: To a solution of 3-pyridinecarboxaldehyde (79 mg, 0.5 mmol), 2-aminoethanol (200 μL, 3.2 mmol), and pyridine (80 μL, 1.0 mmol) in methanol (6 mL) was added PTAB (trimethylphenyltrimethyl ammonium trimethylammonium tribromide, 376 mg, 1.0 mmol). The reaction mixture was stirred at room temperature for 22 hours and then treated with 0.5 M aqueous Na2S2O3 (10 mL) and 1.0 M aqueous NaHCO3 (15 mL), followed by extraction with EtOAc (60 mL). The organic layer was washed sequentially with 0.5 M Na2S2O3 aqueous solution and saturated NaCl aqueous solution and dried with MgSO4. After the solvent was removed under vacuum, the residue was purified by column chromatography on silica gel (Wako C-200), the eluent being a mixture of CCl4 and CCl4-CHCl3 (2:1 v/v) to afford 3-(4,5-dihydro-2-oxazolyl)-pyridine (85 mg) in 86% yield.

References

[1] Heterocycles, 2017, vol. 94, # 5, p. 979 - 990

Pyridine, 3-(4,5-dihydro-2-oxazolyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyridine, 3-(4,5-dihydro-2-oxazolyl)- Suppliers

Canada 1 China 93 India 5 United States 6 Global 105
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View Lastest Price from Pyridine, 3-(4,5-dihydro-2-oxazolyl)- manufacturers

Moxin Chemicals
Product
Nicorandil Impurity D 40055-37-6
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95%+
Supply Ability
100000
Release date
2025-01-15

40055-37-6, Pyridine, 3-(4,5-dihydro-2-oxazolyl)-Related Search:

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  • Pyridine, 3-(4,5-dihydro-2-oxazolyl)-
  • 2-(3-Pyridyl)-2-oxazoline
  • 2-pyridin-3-yl-4,5-dihydro-1,3-oxazole
  • 2-(Pyridin-3-yl)-4,5-dihydrooxazole
  • Nicorandil Impurity 3
  • Nicorandil EP Impurity D
  • Nicorandil Impurity 4(Nicorandil EP Impurity D)
  • Nicorandil EP Impurity 4
  • Nicodil EP impuritiy 1
  • 2-Pyridin-3-yl-2-oxazoline
  • 40055-37-6