ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE

Product Name: ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE
CAS No.: 15854-08-7
Chemical Name: ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE
Synonyms: aPKC-IN-2;AURORA 20241;AKOS MSC-0440;BUTTPARK 82\18-60;AKOS BBS-00000796;MFCD01827729,MFCD-01827729;MFCD01827729, 10 mM in DMSO;Ethyl 2-amino-4-p-tolythiophene-3-carboxylate;ethyl 2-aMino-4-p-tolylthiophene-3-carboxylate;Ethyl 2-amino-4-p-tolylthiophene-3-carboxylate
CBNumber: CB6261782
Molecular Formula: C14H15NO2S
Formula Weight: 261.34
MOL File: 15854-08-7.mol

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ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE Property

Melting point:: 105-107℃
Boiling point:: 401.5±45.0 °C(Predicted)
Density: 1.203±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: -0.04±0.14(Predicted)
form: solid
color: Off-white to light yellow

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B434245
Product name: Ethyl2-Amino-4-(4-methylphenyl)thiophene-3-carboxylate
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 028941
Product name: Ethyl 2-amino-4-(4-methylphenyl)thiophene-3-carboxylate
Packaging: 500mg
Price: $126
Updated: 2021/12/16

AK Scientific

Product number: 5002AD
Product name: Ethyl2-amino-4-(4-methylphenyl)thiophene-3-carboxylate
Packaging: 500mg
Price: $202
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0020334
Product name: 2-AMINO-4-P-TOLYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $672.09
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0020334
Product name: 2-AMINO-4-P-TOLYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 10G
Price: $1497.92
Updated: 2021/12/16

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ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE Chemical Properties,Usage,Production

Uses

aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC50 value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors[1].

References

[1] Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors

ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE Preparation Products And Raw materials

Raw materials

Sulfur Ethanol Diethylamine 4'-Methylacetophenone Benzene Acetic acid Ammonium acetate Ethyl cyanoacetate

Preparation Products

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ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE Suppliers

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15854-08-7, ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATERelated Search:

ETHYL 2-AMINO-4-[1,1'-BIPHENYL]-4-YL-3-THIOPHENECARBOXYLATE Ethyl 2-amino-4-(4-tert-butylphenyl)-5-methylthiophene-3-carboxylate ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE Ethyl 2-amino-4-(4-isopropylphenyl)-5-methylthiophene-3-carboxylate 2-AMINO-4-(4-ISOPROPYL-PHENYL)-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER CHEMBRDG-BB 3000803 2-(2-CHLORO-ACETYLAMINO)-4-P-TOLYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl 2-amino-4-(4-butylphenyl)-5-methylthiophene-3-carboxylate 3-THIOPHENECARBOXYLIC ACID, 2-AMINO-4-[4-(1,1-DIMETHYLETHYL)PHENYL]-, ETHYL ESTER AKOS B000896 Ethyl 2-amino-5-methyl-4-(4-propylphenyl)-thiophene-3-carboxylate Ethyl 2-amino-4-(4-sec-butylphenyl)-5-methylthiophene-3-carboxylate Ethyl 2-amino-4-(4-butylphenyl)thiophene-3-carboxylate ETHYL 2-AMINO-4-(3,4-DIMETHYLPHENYL)THIOPHENE-3-CARBOXYLATE AKOS B000801 AURORA 11585 AURORA 23063 AURORA 20296

AKOS BBS-00000796

AKOS MSC-0440

3-THIOPHENECARBOXYLIC ACID, 2-AMINO-4-(4-METHYLPHENYL)-, ETHYL ESTER

2-AMINO-4-P-TOLYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

AURORA 20241

BUTTPARK 82\18-60

ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE

ETHYL 2-AMINO-4-(4-METHYLPHENYL)THIOPHENE-3-CARBOXYLATE

Ethyl 2-amino-4-p-tolythiophene-3-carboxylate

Ethyl 2-aMino-4-(p-tolyl)thiophene-3-carboxylate, 97+%

2-Amino-3-(ethoxycarbonyl)-4-(4-methylphenyl)thiophene

ethyl 2-aMino-4-p-tolylthiophene-3-carboxylate

2-amino-4-(4-methylphenyl)-3-thiophenecarboxylic acid ethyl ester

2-amino-4-(4-methylphenyl)thiophene-3-carboxylic acid ethyl ester

MFCD01827729,MFCD-01827729

MFCD01827729, 10 mM in DMSO

Ethyl 2-amino-4-<i>p</i>-tolylthiophene-3-carboxylate

aPKC-IN-2

15854-08-7