ChemicalBook > CAS DataBase List > ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE

ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE

Product Name
ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE
CAS No.
15854-08-7
Chemical Name
ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE
Synonyms
aPKC-IN-2;AURORA 20241;AKOS MSC-0440;BUTTPARK 82\18-60;AKOS BBS-00000796;MFCD01827729,MFCD-01827729;MFCD01827729, 10 mM in DMSO;Ethyl 2-amino-4-p-tolythiophene-3-carboxylate;ethyl 2-aMino-4-p-tolylthiophene-3-carboxylate;Ethyl 2-amino-4-p-tolylthiophene-3-carboxylate
CBNumber
CB6261782
Molecular Formula
C14H15NO2S
Formula Weight
261.34
MOL File
15854-08-7.mol
More
Less

ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE Property

Melting point:
105-107℃
Boiling point:
401.5±45.0 °C(Predicted)
Density 
1.203±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
pka
-0.04±0.14(Predicted)
form 
solid
color 
Off-white to light yellow
More
Less

Safety

Hazard Codes 
Xi
Safety Statements 
24/25
HazardClass 
IRRITANT
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B434245
Product name
Ethyl2-Amino-4-(4-methylphenyl)thiophene-3-carboxylate
Packaging
500mg
Price
$90
Updated
2021/12/16
Matrix Scientific
Product number
028941
Product name
Ethyl 2-amino-4-(4-methylphenyl)thiophene-3-carboxylate
Packaging
500mg
Price
$126
Updated
2021/12/16
AK Scientific
Product number
5002AD
Product name
Ethyl2-amino-4-(4-methylphenyl)thiophene-3-carboxylate
Packaging
500mg
Price
$202
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0020334
Product name
2-AMINO-4-P-TOLYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
Purity
95.00%
Packaging
1G
Price
$672.09
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0020334
Product name
2-AMINO-4-P-TOLYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
Purity
95.00%
Packaging
10G
Price
$1497.92
Updated
2021/12/16
More
Less

ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE Chemical Properties,Usage,Production

Uses

aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC50 value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors[1].

References

[1] Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors

ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE Preparation Products And Raw materials

Raw materials

Sulfur Ethanol Diethylamine 4'-Methylacetophenone Benzene Acetic acid Ammonium acetate Ethyl cyanoacetate

Preparation Products

More
Less

ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE Suppliers

Austria 1 China 26 Germany 2 Hungary 1 India 2 The Netherlands 1 Ukraine 2 United Kingdom 2 United States 9 Global 46
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

15854-08-7, ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATERelated Search:

ETHYL 2-AMINO-4-[1,1'-BIPHENYL]-4-YL-3-THIOPHENECARBOXYLATE Ethyl 2-amino-4-(4-tert-butylphenyl)-5-methylthiophene-3-carboxylate ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE Ethyl 2-amino-4-(4-isopropylphenyl)-5-methylthiophene-3-carboxylate 2-AMINO-4-(4-ISOPROPYL-PHENYL)-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER CHEMBRDG-BB 3000803 2-(2-CHLORO-ACETYLAMINO)-4-P-TOLYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl 2-amino-4-(4-butylphenyl)-5-methylthiophene-3-carboxylate 3-THIOPHENECARBOXYLIC ACID, 2-AMINO-4-[4-(1,1-DIMETHYLETHYL)PHENYL]-, ETHYL ESTER AKOS B000896 Ethyl 2-amino-5-methyl-4-(4-propylphenyl)-thiophene-3-carboxylate Ethyl 2-amino-4-(4-sec-butylphenyl)-5-methylthiophene-3-carboxylate Ethyl 2-amino-4-(4-butylphenyl)thiophene-3-carboxylate ETHYL 2-AMINO-4-(3,4-DIMETHYLPHENYL)THIOPHENE-3-CARBOXYLATE AKOS B000801 AURORA 11585 AURORA 23063 AURORA 20296

  • AKOS BBS-00000796
  • AKOS MSC-0440
  • 3-THIOPHENECARBOXYLIC ACID, 2-AMINO-4-(4-METHYLPHENYL)-, ETHYL ESTER
  • 2-AMINO-4-P-TOLYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
  • AURORA 20241
  • BUTTPARK 82\18-60
  • ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE
  • ETHYL 2-AMINO-4-(4-METHYLPHENYL)THIOPHENE-3-CARBOXYLATE
  • Ethyl 2-amino-4-p-tolythiophene-3-carboxylate
  • Ethyl 2-aMino-4-(p-tolyl)thiophene-3-carboxylate, 97+%
  • 2-Amino-3-(ethoxycarbonyl)-4-(4-methylphenyl)thiophene
  • ethyl 2-aMino-4-p-tolylthiophene-3-carboxylate
  • 2-amino-4-(4-methylphenyl)-3-thiophenecarboxylic acid ethyl ester
  • 2-amino-4-(4-methylphenyl)thiophene-3-carboxylic acid ethyl ester
  • MFCD01827729,MFCD-01827729
  • MFCD01827729, 10 mM in DMSO
  • Ethyl 2-amino-4-<i>p</i>-tolylthiophene-3-carboxylate
  • aPKC-IN-2
  • 15854-08-7