ChemicalBook > CAS DataBase List > E-3810

E-3810

Product Name
E-3810
CAS No.
1058137-23-7
Chemical Name
E-3810
Synonyms
E-3810;CS-655;AL3810;CO-3810;CS-1836;S 80881;Lucitanib;AL3810 (AL-3810;Lucitanib(E3810);E-3810 USP/EP/BP
CBNumber
CB62624136
Molecular Formula
C26H25N3O4
Formula Weight
443.49
MOL File
1058137-23-7.mol
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E-3810 Property

Boiling point:
696.5±50.0 °C(Predicted)
Density 
1.285±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
14.65±0.46(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0782
Product name
Lucitanib
Purity
99.32%
Packaging
2mg
Price
$132
Updated
2021/12/16
ChemScene
Product number
CS-0782
Product name
Lucitanib
Purity
99.32%
Packaging
5mg
Price
$228
Updated
2021/12/16
ChemScene
Product number
CS-0782
Product name
Lucitanib
Purity
99.32%
Packaging
10mg
Price
$372
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0017256
Product name
E-3810
Purity
95.00%
Packaging
5MG
Price
$427.9
Updated
2021/12/16
Biorbyt Ltd
Product number
orb180999
Product name
Lucitanib(E3810)
Purity
>98%
Packaging
100mg
Price
$690.2
Updated
2021/12/16
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E-3810 Chemical Properties,Usage,Production

Uses

Lucitanib (E-3810) is a novel dual inhibitor of VEGFR and FGFR, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50s of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively[1][2][3].

Definition

ChEBI: A naphthalenecarboxamide obtained from formal condensation of the carboxy group of aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-1-naphthoic acid with methylamine.

in vivo

Lucitanib (E-3810), at oral dosing of 20 mg/kg for 7 consecutive days, completely inhibits (P<0.01) the bFGF induced angiogenic response compare with the response in vehicle-treated mice. Lucitanib (E-3810) shows a broad spectrum of activity, being active in all the xenografts tested (HT29 colon carcinoma, A2780 ovarian carcinoma, A498, SN12K1, and RXF393 renal carcinomas) with dose-dependent inhibition of tumor growth. E-3810 significantly delays growth during treatment, but tumors resume their growth when treatment is suspended; in a few cases, tumor regression is observed[1]. The activity of Lucitanib (E-3810) given at the doses of 15 mg/kg is tested on MDA-MB-231 breast cancer transplanted subcutaneously, at a late stage, when tumor masses reach 350 to 400 mg. This tumor xenograft is very sensitive to Lucitanib (E-3810), with complete tumor stabilization lasting throughout the 30-day treatment. As in other tumor models, tumors re-grow after withdrawal of Lucitanib (E-3810) at a rate similar to control tumors[3].

target

VEGFR-1

IC 50

VEGFR1: 7 nM (IC50); VEGFR2: 25 nM (IC50); VEGFR3: 10 nM (IC50); FGFR1: 17.5 nM (IC50); FGFR2: 82.5 nM (IC50)

References

[1] Bello E, et al. E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405. DOI:10.1158/0008-5472.CAN-10-2700
[2] Colzani M, et al. Quantitative chemical proteomics identifies novel targets of the anti-cancer multi-kinase inhibitor E-3810. Mol Cell Proteomics. 2014 Jun;13(6):1495-509. DOI:10.1074/mcp.M113.034173
[3] Bello E, et al. The tyrosine kinase inhibitor E-3810 combined with NSC 125973 inhibits the growth of advanced-stage triple-negative breast cancer xenografts. Mol Cancer Ther. 2013 Feb;12(2):131-40 DOI:10.1158/1535-7163.MCT-12-0275-T

E-3810 Preparation Products And Raw materials

Raw materials

Preparation Products

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E-3810 Suppliers

China 85 United States 9 Global 94
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
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60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55

1058137-23-7, E-3810Related Search:

Iodide oil

  • Lucitanib(E3810)
  • CS-655
  • CS-1836
  • CO-3810
  • E 3810; E-3810;CO-3810; S 80881; E-3810
  • S 80881
  • E-3810
  • 6-[[7-[(1-Aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl-1-naphthalenecarboxamide
  • E-3810(Lucitanib)
  • Lucitanib
  • 6-[[7-[(1-Aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl-1-naphthalenecarboxamide E-3810(Lucitanib)
  • 6-((7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-N-methyl-1-naphthamide
  • AL3810
  • 6-({7-[(1-Aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl}oxy)-N-methyl-1-naphthamide
  • 1-Naphthalenecarboxamide, 6-[[7-[(1-aminocyclopropyl)methoxy]-6-methoxy-4-quinolinyl]oxy]-N-methyl-
  • E-3810 USP/EP/BP
  • Lucitanib(AL3810）
  • Fibroblast growth factor receptor,Vascular endothelial growth factor receptor,Inhibitor,FGFR,E3810,inhibit,Lucitanib,E 3810,VEGFR
  • Lucitanib, 10 mM in DMSO
  • Lucitanib (E3810) hydrochloride
  • AL3810 (AL-3810
  • 1058137-23-7