N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide
- Product Name
- N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide
- CAS No.
- 301675-24-1
- Chemical Name
- N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide
- Synonyms
- IRAK-4 protein kinase inhibitor 2;Benzamide, N-1H-benzimidazol-2-yl-3-nitro-;3-nitro-N-(1H-benzoimidazol-2-yl)-benzamide;N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide;N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide-2;IRAK-4 protein kinase inhibitor 2, 10 mM in DMSO;Inhibitor,inhibit,IRAK-4,interleukin-1,IRAK-4 protein kinase inhibitor 2,immune,IRAK 4 protein kinase inhibitor 2,IRAK,Interleukin-1 receptor associated kinase,inflammatory,IL-1,IL-1R associated kinase,IRAK4 protein kinase inhibitor 2
- CBNumber
- CB62624242
- Molecular Formula
- C14H10N4O3
- Formula Weight
- 282.2542
- MOL File
- 301675-24-1.mol
N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 10 mg/mL (35.43 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-M1436
- Product name
- IRAK-4proteinkinaseinhibitor2
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide Chemical Properties,Usage,Production
Uses
IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders[1].
Biological Activity
IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders[1]. IRAK-4 protein kinase inhibitor 2 (compound 1) also inhibits IRAK-1, with an IC50 of <10 μM[1].
IC 50
IRAK4: 4 μM (IC50)
References
[1]. Powers JP, et, al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.
N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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