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INCB8761(PF-4136309)

Product Name
INCB8761(PF-4136309)
CAS No.
1341224-83-6
Chemical Name
INCB8761(PF-4136309)
Synonyms
CS-1440;EOS-61910;NCB8761(PF-4136309);INCB8761(PF-4136309);PF-04136309(INCB-8761);ZNSVOHSYDRPBGI-LXWOLXCRSA-N;N-(2-((S)-3-(((1R,4S)-4-HYDROXY-4-(5-(PYRIMIDIN-2-YL);INCB8761; PF-4136309; PF4136309; PF 4136309; INCB-8761;INCB-8761,INCB 8761,inhibit,PF-4136309,CC chemokine receptor,CCR,Inhibitor,PF4136309;N-(2-((S)-3-((trans-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
CBNumber
CB62627975
Molecular Formula
C29H31F3N6O3
Formula Weight
568.59
MOL File
1341224-83-6.mol
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INCB8761(PF-4136309) Property

Boiling point:
712.2±60.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to at least 25 mg/ml)
pka
13.17±0.46(Predicted)
form 
solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21965
Product name
INCB 8761
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21965
Product name
INCB 8761
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
21965
Product name
INCB 8761
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
21965
Product name
INCB 8761
Packaging
25mg
Price
$533
Updated
2024/03/01
ChemScene
Product number
CS-0610
Product name
PF-4136309
Purity
99.59%
Packaging
100mg
Price
$760
Updated
2021/12/16
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INCB8761(PF-4136309) Chemical Properties,Usage,Production

Description

PF-4136309 is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50s = 5.2, 13, and 17 nM for the human, rat, and mouse receptors, respectively). It also inhibits the voltage-gated potassium channel subtype Kv11.1 by 35% when used at a concentration of 10 μM. PF-4136309 decreases isolated human monocyte chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 3.9 nM.

Uses

PF 4136309 is a CCR5 receptor antagonists that contributes to the treatment of rheumatoid arthritis.

References

1) Chu-Biao?et al.?(2011),?Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist;?ACS Med. Chem. Lett.?2?913 2) Sanford?et al.?(2013),?Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis;?Clin. Cancer Res.?19?3404 3) Nywenig?et al.?(2016),?Phase 1b study targeting tumor associated macrophages with CCR2 inhibition plus FOLFIRINOX in locally advanced and borderline resectable pancreatic cancer;?Lancet Oncol.?17?651

INCB8761(PF-4136309) Preparation Products And Raw materials

Raw materials

Preparation Products

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INCB8761(PF-4136309) Suppliers

China 80 United States 9 Global 89
Shanghai Boyle Chemical Co., Ltd.
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Fax
86-21-57758967
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sales@boylechem.com
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China
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Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
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China
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7552
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61
Shanghai Taibao Pharmaceutical Technology Co., Ltd.
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13816752554
Email
1745533547@qq.com
Country
China
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129
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
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025-68650336
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info@adooq.cn
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China
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Shanghai XingMo Biotechnology Co., Ltd.
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13524779951
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QQ: 2075692521
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2075692521@qq.com
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China
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LETOPHARM LIMITED
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+86-21-5821 5861
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+86-21-5106 2861
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sales@letopharm.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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AN PharmaTech Co Ltd
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86(21)68097365
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86(21)33321566
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sales@anpharma.net
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China
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4891
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SPIRO PHARMA
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eric_feng1954@126.com
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Codow Chemical Co.,Ltd.
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18620099427
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+86-20-62619665
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amy@howeipharm.com
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China
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1341224-83-6, INCB8761(PF-4136309)Related Search:

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  • INCB8761(PF-4136309)
  • NCB8761(PF-4136309)
  • PF-04136309(INCB-8761)
  • Benzamide, N-[2-[(3S)-3-[[trans-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)-
  • EOS-61910
  • N-(2-((S)-3-(((1r,4S)-4-hydroxy-4-(5-(pyrimidin-2-yl) yridine-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
  • ZNSVOHSYDRPBGI-LXWOLXCRSA-N
  • N-(2-((S)-3-(((1R,4S)-4-HYDROXY-4-(5-(PYRIMIDIN-2-YL)
  • CS-1440
  • INCB8761; PF-4136309; PF4136309; PF 4136309; INCB-8761
  • N-(2-((S)-3-((trans-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
  • INCB-8761,INCB 8761,inhibit,PF-4136309,CC chemokine receptor,CCR,Inhibitor,PF4136309
  • 1341224-83-6