RO 9187

Product Name: RO 9187
CAS No.: 876708-03-1
Chemical Name: RO 9187
Synonyms: RO 9187;RO 9187;RO9187;2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-;4-Amino-1-(4-C -azido-β-D-arabinofuranosyl)-2 (1H )-pyrimidinone;4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
CBNumber: CB62628361
Molecular Formula: C9H12N6O5
Formula Weight: 284.22878
MOL File: 876708-03-1.mol

More

Less

RO 9187 Property

Melting point:: 188.0-189.0℃
storage temp.: Store at -20°C
solubility: H2O : 7.14 mg/mL (25.12 mM; Need ultrasonic)
form: Powder
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0954
Product name: RO-9187
Purity: ≥98.0%
Packaging: 5mg
Price: $244
Updated: 2021/12/16

ChemScene

Product number: CS-0954
Product name: RO-9187
Purity: ≥98.0%
Packaging: 10mg
Price: $319
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611734
Product name: RO-9187
Packaging: 10mg
Price: $440.3
Updated: 2021/12/16

ChemScene

Product number: CS-0954
Product name: RO-9187
Purity: ≥98.0%
Packaging: 50mg
Price: $869
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611734
Product name: RO-9187
Packaging: 50mg
Price: $882.3
Updated: 2021/12/16

More

Less

RO 9187 Chemical Properties,Usage,Production

Biological Activity

RO-9187 is a potent inhibitor of HCV viral replication with IC50 value of 171 nM.

in vitro

RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. It inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-C-methyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12 μM RO-9187.

in vivo

Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day.

target

IC50: 171 nM (HCV)

RO 9187 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

RO 9187 Suppliers

China 56 United States 7 Global 63

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52925
Advantage: 58

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

876708-03-1, RO 9187Related Search:

2'-Deoxycytidine gamma-Cyclodextrin

RO 9187

4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone

RO 9187;RO9187

4-Amino-1-(4-C -azido-β-D-arabinofuranosyl)-2 (1H )-pyrimidinone

2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-

876708-03-1