ChemicalBook > CAS DataBase List > 1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine

1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine

Product Name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine
CAS No.: 86770-76-5
Chemical Name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine
Synonyms: CAS_86770-76-5;H2N-(CH2CH2O)4-Bn;Benzyl-PEG4-amine;BnO-PEG3-CH2CH2NH2;1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine;3,6,9,12-Tetraoxatridecan-1-amine, 13-phenyl-;2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethanamine;BnO-PEG3-CH2CH2NH2/3,6,9,12-Tetraoxatridecan-1-amine, 13-phenyl-
CBNumber: CB62640730
Molecular Formula: C15H25NO4
Formula Weight: 283.3633
MOL File: 86770-76-5.mol

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1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine Property

Boiling point:: 390.4±32.0 °C(Predicted)
Density: 1.061±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: Liquid
pka: 8.74±0.10(Predicted)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0387318
Product name: 1-PHENYL-2,5,8,11-TETRAOXATRIDECAN-13-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $495.22
Updated: 2021/12/16

AK Scientific

Product number: V8229
Product name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-amine
Packaging: 10g
Price: $2024
Updated: 2021/12/16

Alichem

Product number: 86770765
Product name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine
Packaging: 5g
Price: $737.83
Updated: 2021/12/16

Acrotein

Product number: B-0812
Product name: BnO-PEG3-CH2CH2NH2
Purity: 97%
Packaging: 5g
Price: $825
Updated: 2021/12/16

Crysdot

Product number: CD12022206
Product name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-amine
Purity: 95+%
Packaging: 5g
Price: $922
Updated: 2021/12/16

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1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine Chemical Properties,Usage,Production

Uses

Benzyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Synthesis

86770-71-0

86770-76-5

Triphenylphosphine (59.7 g, 227.7 mmol) was slowly added to a stirred solution of azide 23 (55.2 g, 178.4 mmol) in anhydrous tetrahydrofuran (700 mL) at 0 °C. The reaction mixture was stirred continuously for 10 hours at room temperature. Subsequently, water (5.8 mL, 323.4 mmol) was added to hydrolyze the intermediate phosphorus adduct. After continued stirring for 10 hours, the reaction mixture was diluted with water (1000 mL) and washed with toluene (200 mL, twice). The aqueous phase was concentrated by evaporation to afford the target product 1-phenyl-2,5,8,11-tetraoxatridecan-13-amine (50.6 g, 91% yield). The product was characterized by 1HNMR (400 MHz, CD3OD): δ 7.11-7.29 (m, 5H), 4.51 (s, 2H), 3.55-3.64 (m, 12H), 3.43 (t, J=5.2Hz, 2H), 2.78 (t, J=5.2Hz, 2H).

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Benzyl-PEG4-NH2 86770-76-5
Price: US $0.00/g
Min. Order: 10g
Purity: >98.00%
Supply Ability: 10g
Release date: 2024-03-25

86770-76-5, 1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMineRelated Search:

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1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine

Benzyl-PEG4-amine

2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethanamine

BnO-PEG3-CH2CH2NH2

CAS_86770-76-5

H2N-(CH2CH2O)4-Bn

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3,6,9,12-Tetraoxatridecan-1-amine, 13-phenyl-

86770-76-5