1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine
- Product Name
- 1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine
- CAS No.
- 86770-76-5
- Chemical Name
- 1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine
- Synonyms
- CAS_86770-76-5;H2N-(CH2CH2O)4-Bn;Benzyl-PEG4-amine;BnO-PEG3-CH2CH2NH2;1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine;3,6,9,12-Tetraoxatridecan-1-amine, 13-phenyl-;2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethanamine;BnO-PEG3-CH2CH2NH2/3,6,9,12-Tetraoxatridecan-1-amine, 13-phenyl-
- CBNumber
- CB62640730
- Molecular Formula
- C15H25NO4
- Formula Weight
- 283.3633
- MOL File
- 86770-76-5.mol
1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine Property
- Boiling point:
- 390.4±32.0 °C(Predicted)
- Density
- 1.061±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Liquid
- pka
- 8.74±0.10(Predicted)
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CHM0387318
- Product name
- 1-PHENYL-2,5,8,11-TETRAOXATRIDECAN-13-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.22
- Updated
- 2021/12/16
- Product number
- V8229
- Product name
- 1-Phenyl-2,5,8,11-tetraoxatridecan-13-amine
- Packaging
- 10g
- Price
- $2024
- Updated
- 2021/12/16
- Product number
- 86770765
- Product name
- 1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine
- Packaging
- 5g
- Price
- $737.83
- Updated
- 2021/12/16
- Product number
- B-0812
- Product name
- BnO-PEG3-CH2CH2NH2
- Purity
- 97%
- Packaging
- 5g
- Price
- $825
- Updated
- 2021/12/16
- Product number
- CD12022206
- Product name
- 1-Phenyl-2,5,8,11-tetraoxatridecan-13-amine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $922
- Updated
- 2021/12/16
1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine Chemical Properties,Usage,Production
Uses
Benzyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Synthesis
86770-71-0
86770-76-5
Triphenylphosphine (59.7 g, 227.7 mmol) was slowly added to a stirred solution of azide 23 (55.2 g, 178.4 mmol) in anhydrous tetrahydrofuran (700 mL) at 0 °C. The reaction mixture was stirred continuously for 10 hours at room temperature. Subsequently, water (5.8 mL, 323.4 mmol) was added to hydrolyze the intermediate phosphorus adduct. After continued stirring for 10 hours, the reaction mixture was diluted with water (1000 mL) and washed with toluene (200 mL, twice). The aqueous phase was concentrated by evaporation to afford the target product 1-phenyl-2,5,8,11-tetraoxatridecan-13-amine (50.6 g, 91% yield). The product was characterized by 1HNMR (400 MHz, CD3OD): δ 7.11-7.29 (m, 5H), 4.51 (s, 2H), 3.55-3.64 (m, 12H), 3.43 (t, J=5.2Hz, 2H), 2.78 (t, J=5.2Hz, 2H).
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine Suppliers
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- Country
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- 6700
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View Lastest Price from 1-Phenyl-2,5,8,11-tetraoxatridecan-13-aMine manufacturers
- Product
- Benzyl-PEG4-NH2 86770-76-5
- Price
- US $0.00/g
- Min. Order
- 10g
- Purity
- >98.00%
- Supply Ability
- 10g
- Release date
- 2024-03-25