Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)
- Product Name
- Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)
- CAS No.
- 118591-58-5
- Chemical Name
- Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate)
- Synonyms
- peg2-tos;Tos-PEG2-OH;OH-PEG2-Tos;HO-PEG2-OTS;CAS_118591-58-5;Tos-PEG2-alcohol;Diethylene glycol p-toluenesulfonate;diethylene glycol mono-p-toluenesulfonate;2-(2-Hydroxyethoxy)ethyl 4-Methylbenzensulfonate;2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
- CBNumber
- CB62648165
- Molecular Formula
- C11H16O5S
- Formula Weight
- 260.30674
- MOL File
- 118591-58-5.mol
Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) Property
- Boiling point:
- 427.4±30.0 °C(Predicted)
- Density
- 1.256±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.32±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C11H16O5S/c1-10-2-4-11(5-3-10)17(13,14)16-9-8-15-7-6-12/h2-5,12H,6-9H2,1H3
- InChIKey
- KLDLLRZCWYKJBD-UHFFFAOYSA-N
- SMILES
- C(OS(C1=CC=C(C)C=C1)(=O)=O)COCCO
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ANV00334
- Product name
- 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
- Packaging
- 1G
- Price
- $497
- Updated
- 2025/07/31
- Product number
- 182262
- Product name
- 2-(2-Hydroxyethoxy)ethyl 4-methylbenzenesulfonate
- Purity
- 95%
- Packaging
- 5g
- Price
- $1238
- Updated
- 2021/12/16
- Product number
- A151206
- Product name
- 2-(2-Hydroxyethoxy)ethyl4-methylbenzenesulfonate
- Purity
- 98%
- Packaging
- 100mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- A151206
- Product name
- 2-(2-Hydroxyethoxy)ethyl4-methylbenzenesulfonate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 118591585
- Product name
- 2-(2-Hydroxyethoxy)ethyl4-methylbenzenesulfonate
- Packaging
- 100mg
- Price
- $180.36
- Updated
- 2021/12/16
Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) Chemical Properties,Usage,Production
Uses
Tos-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Synthesis
98-59-9
111-46-6
118591-58-5
The general procedure for the synthesis of 2-(2-hydroxyethoxy)ethyl 4-methylbenzenesulfonate from p-toluenesulfonyl chloride and diethylene glycol was as follows: first, the diethylene glycol was protected with a monohydroxy group. This was done as follows: in a dichloromethane solvent, potassium iodide (0.2 eq.) was added as a catalyst, followed by freshly prepared silver oxide (1.5 eq.) and p-toluenesulfonyl chloride (1.1 eq.). The reaction mixture was stirred at room temperature for 8-10 h. Upon completion of the reaction, mono-p-toluenesulfonyl-protected diethylene glycol was obtained in 97-99% yield. This step provides a selectively protected intermediate for the subsequent reaction with aconitic acid.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethanol, 2-(2-hydroxyethoxy)-, 1-(4-Methylbenzenesulfonate) manufacturers
- Product
- OH-PEG2-Tos 118591-58-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-25