Streptochlorin
- Product Name
- Streptochlorin
- CAS No.
- 120191-51-7
- Chemical Name
- Streptochlorin
- Synonyms
- SF 2583A;Streptochlorin;Antibiotic SF 2583A;3-(4-Chloro-5-oxazolyl)-1H-indole;4-Chloro-5-(1H-indol-3-yl)oxazole;1H-Indole, 3-(4-chloro-5-oxazolyl)-
- CBNumber
- CB62650834
- Molecular Formula
- C11H7ClN2O
- Formula Weight
- 218.63908
- MOL File
- 120191-51-7.mol
Streptochlorin Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble; Methanol: soluble
- form
- A solid
- color
- Crystalline
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 27605
- Product name
- Streptochlorin
- Packaging
- 1mg
- Price
- $225
- Updated
- 2024/03/01
- Product number
- 27605
- Product name
- Streptochlorin
- Packaging
- 5mg
- Price
- $844
- Updated
- 2024/03/01
- Product number
- 207409
- Product name
- Streptochlorin
- Packaging
- 250ug
- Price
- $316
- Updated
- 2021/12/16
- Product number
- 3685DF
- Product name
- Streptochlorin
- Packaging
- 1mg
- Price
- $417
- Updated
- 2021/12/16
- Product number
- INB0009883
- Product name
- STREPTOCHLORIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $456.05
- Updated
- 2021/12/16
Streptochlorin Chemical Properties,Usage,Production
Description
Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells. It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 μM. Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB).
Uses
Streptochlorin is an antineoplastic agent and a potential chemotherapeutic agent for treating cholangiocarcinoma.
storage
+4°C
Streptochlorin Preparation Products And Raw materials
Raw materials
Preparation Products
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