Ethyl 3-oxocyclohexane-1-carboxylate
- Product Name
- Ethyl 3-oxocyclohexane-1-carboxylate
- CAS No.
- 33668-25-6
- Chemical Name
- Ethyl 3-oxocyclohexane-1-carboxylate
- Synonyms
- ETHYL 3-OXOCYCLOHEXANECARBOXYLATE;3-oxyclohexanethyl formate;Ethyl 3-oxo-cyclohexane formate;Ethyl Cyclohexanone-β-carboxylate;ETHYL 3-OXOCYCLOHEXANE-l-CARBOXYLATE;ETHYL 3-OXOCYCLOHEXANE-1-CARBOXYLATE;Ethyl 3-oxocyclohexane-1-carboxylate 97+%;3-Cyclohexanonecarboxylic acid ethyl ester;3-Oxocyclohexanecarboxylic acid ethyl ester;3-Oxocyclohexane-1-carboxylic acid ethyl ester
- CBNumber
- CB6265528
- Molecular Formula
- C9H14O3
- Formula Weight
- 170.21
- MOL File
- 33668-25-6.mol
Ethyl 3-oxocyclohexane-1-carboxylate Property
- Boiling point:
- 249℃
- Density
- 1.083
- Flash point:
- 104℃
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C9H14O3/c1-2-12-9(11)7-4-3-5-8(10)6-7/h7H,2-6H2,1H3
- InChIKey
- YLRVJPQVDQQBOX-UHFFFAOYSA-N
- SMILES
- C1(C(OCC)=O)CCCC(=O)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E908940
- Product name
- EthylCyclohexanone-β-carboxylate
- Packaging
- 2.5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 2229-1-X3
- Product name
- Ethyl 3-oxocyclohexane-1-carboxylate
- Packaging
- 100mg
- Price
- $31
- Updated
- 2021/12/16
- Product number
- 067079
- Product name
- Ethyl3-Oxocyclohexanecarboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 2229-1-X3
- Product name
- Ethyl 3-oxocyclohexane-1-carboxylate
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 083606
- Product name
- Ethyl 3-oxocyclohexanecarboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
Ethyl 3-oxocyclohexane-1-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl Cyclohexanone-β-carboxylate is an intermediate used to prepare carbazole-carboxamides with selective JAK2 inhibitory activities.
Synthesis Reference(s)
Journal of the American Chemical Society, 110, p. 2565, 1988 DOI: 10.1021/ja00216a033
Hazard
Ethyl 3-oxocyclohexane-1-carboxylate is irritating to the eyes and skin, may cause respiratory irritation, and is harmful if swallowed.
Synthesis
To a round bottom flask was added 3-oxo-1-cyclohexanecarboxylic acid (3.85 g, 27.1 mmol), ethanol (7.91 mL), p-toluenesulfonic acid (0.097 g, 0.56 mmol) and toluene (65.9 mL). The mixture was refluxed with a Dean-star trap overnight. The reaction mixture was cooled down and concentrated under reduced pressure to afford 4.61 g (100 %) of the title compound, 3-oxo-cyclohexanecarboxylic acid ethyl ester (Ethyl 3-oxocyclohexane-1-carboxylate), as a yellow oil.
References
[1] Patent: US2011/98299, 2011, A1. Location in patent: Page/Page column 23
[2] Journal of Fluorine Chemistry, 2017, vol. 199, p. 60 - 66
[3] Journal of the Chemical Society, 1909, vol. 95, p. 2016
[4] Patent: WO2014/11902, 2014, A1. Location in patent: Paragraph 00284-00285
[5] Patent: WO2014/194242, 2014, A2. Location in patent: Paragraph 00353; 00356
Ethyl 3-oxocyclohexane-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 3-oxocyclohexane-1-carboxylate manufacturers
- Product
- Ethyl 3-oxocyclohexane-1-carboxylate 33668-25-6
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-24
- Product
- ethyl-3-oxocyclohexanecarboxylate 33668-25-6
- Price
- US $0.00/gm
- Min. Order
- 100gm
- Purity
- 96%min
- Supply Ability
- 100kgs
- Release date
- 2024-09-10
- Product
- ETHYL 3-OXOCYCLOHEXANE-1-CARBOXYLATE 33668-25-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-15