S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride

Product Name: S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride
CAS No.: 86867-01-8
Chemical Name: S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride
Synonyms: S-(5′SAM; ADOMET;-Adenosyl)-LL-methionine chloride dihydrochloride
CBNumber: CB62655576
Molecular Formula: C15H24Cl2N6O5S
Formula Weight: 471.35
MOL File: 86867-01-8.mol

More

Less

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Property

storage temp.: -20°C
solubility: H2O: soluble100mg/mL
form: A lyophilized powder
color: Off-white to light yellow
BRN: 6560002

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-68/20/21/22
Safety Statements: 36-45
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A7007
Product name: S-(5′-Adenosyl)-L-methionine chloride dihydrochloride
Purity: ≥75%
Packaging: 5mg
Price: $70.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: A7007
Product name: S-(5′-Adenosyl)-L-methionine chloride dihydrochloride
Purity: ≥75%
Packaging: 1g
Price: $1350
Updated: 2024/03/01

Cayman Chemical

Product number: 13956
Product name: S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 13956
Product name: S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)
Purity: ≥95%
Packaging: 2.5mg
Price: $90
Updated: 2024/03/01

Sigma-Aldrich

Product number: A7007
Product name: S-(5′-Adenosyl)-L-methionine chloride dihydrochloride
Purity: ≥75%
Packaging: 25mg
Price: $91.8
Updated: 2024/03/01

More

Less

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Chemical Properties,Usage,Production

Description

S-(5''-Adenosyl)-L-methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases. The transfer of a methyl group from SAM to an acceptor produces S-adenosyl-L-homocysteine . SAM is also metabolized by SAM decarboxlase to give decarboxylated SAM, which is involved in the polyamine pathway that generates spermine. Cayman Chemical’s SAM has been purified to remove all S-adenosylhomocysteine, a known inhibitor of most SAM-dependent methyltransferases which is commonly found in other commercially available SAM. In addition, Cayman’s SAM contains no S-methylthioadenosine, a common impurity which may act as a substrate in some assay formats, resulting in high background.

Uses

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract. It also has been used for measuring the interaction with catechol-O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles.

General Description

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids and nucleic acids. Methionine adenosyl transferase catalyses the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM functions to regulate various cellular functions like cell division, cell death, transcription, genetic stability, oxidant/antioxidant balance and polyamine homeostasis. Therapeutically, SAM finds its application as a nutritional supplement in humans for various diseases like osteoarthritis and liver injury. SAM also regulates transsulfuration reactions by binding to the regulatory domain of key enzyme cystathionine-β-synthase (CBS).

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Suppliers

China 43 United States 7 Global 50

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4554
Advantage: 62

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4674
Advantage: 55

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Nanjing Derno Pharmaceutical Technology Co., Ltd.

Tel: 025-86957866 13952093866
Fax: 025-68661287
Email: sales@dernopharm.com
Country: China
ProdList: 924
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Hunan Waybel Advanced Materials Co.,Ltd

Tel: 133-0845-3923 13319523173
Email: ivy@hnhbsj.com
Country: China
ProdList: 457
Advantage: 60

Aikon International Limited

Tel: 025-66028182 18112977050
Fax: (3)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 15818
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52693
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-010-010-62971590 18548936886
Fax: 010-62340519
Email: jack@oka-vip.com
Country: China
ProdList: 6897
Advantage: 58

86867-01-8, S-(5'-Adenosyl)-L-Methionine chloride dihydrochlorideRelated Search:

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride

SAM chloride dihydrochloride

5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine chloride dihydrochloride

S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)

SAM; ADOMET

S-(5'-Adenosyl)-L-methionine chloride(SAM)

-Adenosyl)-<SC>L</SC>-methionine chloride dihydrochloride

-Adenosyl)-L-methionine chloride (hydrochloride)

S-(5'-Adenosyl)-L-methionine chloride dihydrochloride >=75%

((S)-3-Amino-3-carboxypropyl)(((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonium chloride dihydrochloride

[(3S)-3-amino-3-carboxypropyl]-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-methylsulfanium

S-Adenosyl-L-methionine (chloride dihydrochloride)

-Adenosyl)-<SC>L<

S-(5&#8242

86867-01-8

C15H23N6O5S2HClCl