ChemicalBook > CAS DataBase List > GDC-0032

GDC-0032

Product Name
GDC-0032
CAS No.
1282512-48-4
Chemical Name
GDC-0032
Synonyms
RG-7604;CS-1435;GDC-0032;GDC-3002;Taselisib;RG7604/GDC-0032;GDC-0032/(RG-7604);Arimoclomol Maleate;GDC-0032 (Taselisib);Taselisib (GDC-0032)
CBNumber
CB62658188
Molecular Formula
C24H28N8O2
Formula Weight
460.53
MOL File
1282512-48-4.mol
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GDC-0032 Property

Boiling point:
783.3±70.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥23.05 mg/mL in DMSO; insoluble in H2O; ≥2.79 mg/mL in EtOH with gentle warming
form 
solid
pka
15.54±0.50(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17387
Product name
GDC-0032
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
17387
Product name
GDC-0032
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
17387
Product name
GDC-0032
Purity
≥98%
Packaging
10mg
Price
$161
Updated
2024/03/01
TRC
Product number
D446475
Product name
4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-α,α-dimethyl-1H-pyrazole-1-acetamide
Packaging
100mg
Price
$525
Updated
2021/12/16
ApexBio Technology
Product number
B1047
Product name
GDC-0032
Packaging
100mg
Price
$615
Updated
2021/12/16
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GDC-0032 Chemical Properties,Usage,Production

Description

GDC-0032 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoforms α, δ, and γ (IC50s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3Kβ. It is over 1,000-fold selective for p100α over other PI3K-like kinases, including DNA-dependent protein kinase catalytic subunits, ATM, and ATR. GDC-0032 has increased potency in cancer cell lines harboring PIK3CA-activating alterations, and is effective in vivo, suppressing the growth of tumors in a mouse xenograft model at low drug dose levels.

Uses

4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-α,α-dimethyl-1H-pyrazole-1-acetamide is a newly discovered A β-Sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.

target

PI3Kδ

References

[1] ndubaku co1, heffron tp, staben st, baumgardner m, blaquiere n, bradley e, bull r, do s, dotson j, dudley d, edgar ka, friedman ls, goldsmith r, heald ra, kolesnikov a, lee l, lewis c, nannini m, nonomiya j, pang j, price s, prior ww, salphati l, sideris s, wallin jj, wang l, wei b, sampath d, olivero ag. discovery of 2-{3-[2-(1-isopropyl-3-methyl-1h-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1h-pyrazol-1-yl}-2-methylpropanamide (gdc-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity. j med chem. 2013 jun 13;56(11):4597-610.

GDC-0032 Preparation Products And Raw materials

Raw materials

Preparation Products

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GDC-0032 Suppliers

Canada 1 China 111 India 1 United Kingdom 1 United States 18 Global 132
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
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Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
NE Scientific
Tel
--
Fax
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Country
United States
ProdList
5030
Advantage
55
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Creative Enzymes
Tel
--
Fax
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Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
Combi-Blocks Inc.
Tel
--
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Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Axon Medchem LLC
Tel
--
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info@axonmedchem.com
Country
United States
ProdList
763
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58
Matrix Scientific
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sales@matrixscientific.com
Country
United States
ProdList
6632
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80
ChemieTek
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info@chemietek.com
Country
United States
ProdList
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AK Scientific, Inc.
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Email
sales@aksci.com
Country
United States
ProdList
6347
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Selleck Chemicals LLC
Tel
--
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Email
info@selleckchem.com
Country
United States
ProdList
824
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View Lastest Price from GDC-0032 manufacturers

Career Henan Chemical Co
Product
GDC-0032 1282512-48-4
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

1282512-48-4, GDC-0032Related Search:

Tazemetostat (EPZ-6438) Tasisulam tasquinimod

  • GDC-0032
  • RG7604/GDC-0032
  • 4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-α,α-dimethyl-1H-pyrazole-1-acetamide
  • GDC-0032/(RG-7604)
  • 2-Methyl-2-[4-[2-(5-Methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroiMidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanaMide
  • Taselisib
  • 4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide
  • GDC-0032 4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide
  • GDC-0032 (Taselisib)
  • GDC-0032 4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alph
  • RG-7604
  • Arimoclomol Maleate
  • 2-(4-(2-(1-Isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxa
  • Taselisib (GDC-0032)
  • GDC-0032, TASELISIB; RG-7604
  • 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide
  • GDC-0032, 98%, a potent β-sparing small molecule inhibitor of PI3K
  • GDC-3002
  • CS-1435
  • GDC0032; GDC 0032;RG7604
  • Taselisib - GDC 0032 | RG 7604
  • 1H-Pyrazole-1-acetamide, 4-[5,6-dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-α,α-dimethyl-
  • 1282512-48-4
  • Inhibitors