Tasisulam
- Product Name
- Tasisulam
- CAS No.
- 519055-62-0
- Chemical Name
- Tasisulam
- Synonyms
- CS-519;TS81557;Tssolan;Ly573636;Ly-573636;tasisulam;LY573636-sodium;Tasisulam, >=98%;Tasisulam(Ly-573636;Tasisulam USP/EP/BP
- CBNumber
- CB71518538
- Molecular Formula
- C11H6BrCl2NO3S2
- Formula Weight
- 415.11
- MOL File
- 519055-62-0.mol
Tasisulam Property
- Density
- 1.812
- storage temp.
- Store at -20° C
- solubility
- DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.2 mg/ml
- form
- A crystalline solid
- pka
- 3.45±0.10(Predicted)
- color
- Light yellow to yellow
- InChI
- InChI=1S/C11H6BrCl2NO3S2/c12-9-3-4-10(19-9)20(17,18)15-11(16)7-2-1-6(13)5-8(7)14/h1-5H,(H,15,16)
- InChIKey
- WWONFUQGBVOKOF-UHFFFAOYSA-N
- SMILES
- C(NS(C1SC(Br)=CC=1)(=O)=O)(=O)C1=CC=C(Cl)C=C1Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T4183
- Product name
- Tasisulam
- Packaging
- 10MG
- Price
- $162
- Updated
- 2025/07/31
- Product number
- 21556
- Product name
- Tasisulam
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 21556
- Product name
- Tasisulam
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $84
- Updated
- 2024/03/01
- Product number
- 21556
- Product name
- Tasisulam
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 21556
- Product name
- Tasisulam
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $321
- Updated
- 2024/03/01
Tasisulam Chemical Properties,Usage,Production
Uses
The sodium salt of Tasisulam has potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS).
Biological Activity
Tasisulam (LY573636) is a SPLAM (SPLicing inhibitor sulfonAMide) th at bridges RNA binding motif protein 39 (RBM39; CAPERα, HCC1) and DCAF15 for interaction, thereby promoting (CUL4-DDB1-DDA1-DCAF15) E3 ubiquitin ligase complex-mediated RBM39 ubiquitination and subsequent proteasomal degradation. Tasisulam exerts selective toxicity in parental HCT116 cancer cultures (IC50 = 6.5 μM), but not those harboring non-CUL4-DCAF15-associating RBM39 G268V mutant even at a high concentration of 50 μM.
Synthesis
50-84-0
1152981-12-8
519055-62-0
General procedure for the synthesis of N-(2,4-dichlorobenzoyl)-5-bromothiophene-2-sulfonamide from 2,4-dichlorobenzoic acid and the compound (CAS:1152981-12-8): 0.5 mmol (0.0955 g) of 2,4-dichlorobenzoic acid, 0.75 mmol (0.2011 g) of 2-bromothiophene-sulfonamide azide, and 0.025 mmol (0.0086 g) octacarbonyldicobalt in a 25 mL reaction tube; subsequently, 4 mL of acetonitrile solvent was added via a microsyringe, and the reaction system was stirred at 80 °C for 4 hours. Upon completion of the reaction, the mixture was concentrated by rotary evaporation and purified by column chromatography (column conditions: 200-300 mesh silica gel, mobile phase ethyl acetate:petroleum ether=1:4) to give 0.1583 g of the target product as a white solid in 76% yield.
References
[1] Chemistry--A European Journal, 2012, vol. 18, # 45, p. 14444 - 14453,10
[2] Chemistry - A European Journal, 2012, vol. 18, # 45, p. 14444 - 14453
[3] Journal of Organic Chemistry, 2018, vol. 83, # 16, p. 9364 - 9369
[4] Patent: CN108558822, 2018, A. Location in patent: Paragraph 0035; 0036; 0037; 0040; 0043
Tasisulam Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tasisulam manufacturers
- Product
- Tasisulam 519055-62-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-26