PAC1

Product Name: PAC1
CAS No.: 315183-21-2
Chemical Name: PAC1
Synonyms: PAC1;DUSP2;PAC1-R;CS-243;PAC1（b）;ADCYAP1R1;PAC-1,PAC1;PAC-1 10MG;PAC 1, >=98%;Pac1 receptor
CBNumber: CB71075505
Molecular Formula: C23H28N4O2
Formula Weight: 392.49
MOL File: 315183-21-2.mol

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PAC1 Property

Density: 1.14
storage temp.: Store at +4°C
solubility: DMSO: ≥10mg/mL
form: solid
pka: 8.82±0.40(Predicted)
color: white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months.

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-36/37/38-50/53
Safety Statements: 26-36/37-60-61
RIDADR: UN 3077
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0115
Product name: PAC-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: P0115
Product name: PAC-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $384
Updated: 2024/03/01

Sigma-Aldrich

Product number: SAB1301755
Product name: ANTI-DUSP2 (C-TERM) antibody produced in rabbit
Purity: IgG fraction of antiserum, buffered aqueous solution
Packaging: 400μL
Price: $461
Updated: 2023/01/07

Cayman Chemical

Product number: 10009317
Product name: PAC-1
Purity: ≥98%
Packaging: 25mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 10009317
Product name: PAC-1
Purity: ≥98%
Packaging: 50mg
Price: $201
Updated: 2024/03/01

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PAC1 Chemical Properties,Usage,Production

Description

PAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2?? Sensitizes cancer cells to various chemotherapeutic agents.3

Uses

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.

Biological Activity

Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively).

storage

+4°C

References

1) Putt et al. (2006), Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy; Nat. Chem. Biol., 2 543 2) Peterson et al. (2009), PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition; J. Mol. Biol., 388 144 3) Bolham et al. (2016), Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with diverse Chemotherapeutics; ACS Cent. Sci., 2 545

PAC1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PAC1 Suppliers

Canada 1 China 102 Germany 1 India 1 Ukraine 1 United Kingdom 3 United States 22 Global 131

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

China Kouting Group Limited

Tel: +86 (21) 5811-6473 5811-6475
Fax: +86 (21) 6129-4103
Email: sales@koutingchina.com
Country: China
ProdList: 496
Advantage: 60

315183-21-2, PAC1Related Search:

AC-VDVAD-PNA Z-VAD-FMK Bortezomib LY2109761 Paclitaxel Obatoclax mesilate 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Ruxolitinib AC-VEID-AMC Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Z-YVAD-AFC ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL AC-VDVAD-CHO AC-DEVD-AFC AC-DEVD-CHO AC-LEHD-AFC AC-LEU-GLU-THR-ASP-AFC PAC1

PAC1

4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide

PAC1,4-(PhenylMethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]Methylene]hydrazide

4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide

PAC-1,PAC1

Procaspase activating coMpound 1

(E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide

4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide PAC-1

PAC 1 4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide

(4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide

1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide

ADCYAP1R1

Pac1 receptor

Pac1 receptors

PAC1-R

PACAP receptor 1

ANTI-DUSP2 (C-TERM) antibody produced in rabbit

Dual specificity protein phosphatase 2

Dual specificity protein phosphatase PAC-1

DUSP2

Anti-DUSP2 (C-terminal) antibody produced in rabbit

PAC 1, >=98%

PAC-1 10MG

PAC-1, 98%, a procaspase-3 activatior

CS-243

PAC 1 - Procaspase activating compound 1

1-Piperazineacetic acid, 4-(phenylmethyl)-, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide

PAC-1 >=98% (HPLC)

PAC1 USP/EP/BP

PAC-1 (VO-100)

N'-(3-Allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide

PAC1（b）

N'-(3-Allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide

315183-21-2

Inhibitor

Inhibitors