ChemicalBook > CAS DataBase List > ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

Product Name
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
CAS No.
10129-56-3
Chemical Name
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
Synonyms
PETCM;APOPTOSIS ACTIVATOR I;α-(Trichloromethyl)-4-pyridineethanol;a-(Trichloromethyl)-4-pyridineethanol;4-Pyridineethanol, α-(trichloromethyl)-;1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL;ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL;1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE;α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
CBNumber
CB8197667
Molecular Formula
C8H8Cl3NO
Formula Weight
240.51
MOL File
10129-56-3.mol
More
Less

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Property

Boiling point:
342.2±37.0 °C(Predicted)
Density 
1.465±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: 22 mg/mL, soluble
form 
solid
pka
12.07±0.20(Predicted)
color 
Light yellow to light brown
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Tocris
Product number
1758
Product name
PETCM
Purity
≥99%(HPLC)
Packaging
50
Price
$189
Updated
2021/12/16
TRC
Product number
P999025
Product name
PETCM
Packaging
1mg
Price
$40
Updated
2021/12/16
Usbiological
Product number
256215
Product name
PETCM
Packaging
50mg
Price
$475
Updated
2021/12/16
ApexBio Technology
Product number
A4420
Product name
PETCM
Packaging
50mg
Price
$329
Updated
2021/12/16
More
Less

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Chemical Properties,Usage,Production

Uses

PETCM is a caspace-3 activator in cell extracts.

Definition

ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines.

Biological Activity

petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1].

storage

Room temperature

References

[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226.

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4983
Advantage
55
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58

10129-56-3, ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOLRelated Search:


  • PETCM
  • APOPTOSIS ACTIVATOR I
  • ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
  • 1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE
  • 1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL
  • a-(Trichloromethyl)-4-pyridineethanol
  • α-(Trichloromethyl)-4-pyridineethanol
  • α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
  • 4-Pyridineethanol, α-(trichloromethyl)-
  • 10129-56-3
  • C8H8Cl3NO
  • C8H8NOCl3
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Apoptosis and Cell Cycle
  • Apoptosis Inducers
  • BioChemical
  • Caspase/Related products.