ChemicalBook > CAS DataBase List > ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

Product Name
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
CAS No.
10129-56-3
Chemical Name
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
Synonyms
PETCM;APOPTOSIS ACTIVATOR I;α-(Trichloromethyl)-4-pyridineethanol;a-(Trichloromethyl)-4-pyridineethanol;4-Pyridineethanol, α-(trichloromethyl)-;1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL;ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL;1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE;α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
CBNumber
CB8197667
Molecular Formula
C8H8Cl3NO
Formula Weight
240.51
MOL File
10129-56-3.mol
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ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Property

Boiling point:
342.2±37.0 °C(Predicted)
Density 
1.465±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: 22 mg/mL, soluble
form 
solid
pka
12.07±0.20(Predicted)
color 
Light yellow to light brown
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
1758
Product name
PETCM
Purity
≥99%(HPLC)
Packaging
50
Price
$189
Updated
2021/12/16
TRC
Product number
P999025
Product name
PETCM
Packaging
1mg
Price
$40
Updated
2021/12/16
Usbiological
Product number
256215
Product name
PETCM
Packaging
50mg
Price
$475
Updated
2021/12/16
ApexBio Technology
Product number
A4420
Product name
PETCM
Packaging
50mg
Price
$329
Updated
2021/12/16
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ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Chemical Properties,Usage,Production

Uses

PETCM is a caspace-3 activator in cell extracts.

Definition

ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines.

Biological Activity

petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1].

storage

Room temperature

References

[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226.

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Suppliers

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10129-56-3, ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOLRelated Search:


  • PETCM
  • APOPTOSIS ACTIVATOR I
  • ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
  • 1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE
  • 1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL
  • a-(Trichloromethyl)-4-pyridineethanol
  • α-(Trichloromethyl)-4-pyridineethanol
  • α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
  • 4-Pyridineethanol, α-(trichloromethyl)-
  • 10129-56-3
  • C8H8Cl3NO
  • C8H8NOCl3
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Apoptosis and Cell Cycle
  • Apoptosis Inducers
  • BioChemical
  • Caspase/Related products.