ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
- Product Name
- ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
- CAS No.
- 10129-56-3
- Chemical Name
- ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
- Synonyms
- PETCM;APOPTOSIS ACTIVATOR I;α-(Trichloromethyl)-4-pyridineethanol;a-(Trichloromethyl)-4-pyridineethanol;4-Pyridineethanol, α-(trichloromethyl)-;1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL;ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL;1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE;α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
- CBNumber
- CB8197667
- Molecular Formula
- C8H8Cl3NO
- Formula Weight
- 240.51
- MOL File
- 10129-56-3.mol
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Property
- Boiling point:
- 342.2±37.0 °C(Predicted)
- Density
- 1.465±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: 22 mg/mL, soluble
- form
- solid
- pka
- 12.07±0.20(Predicted)
- color
- Light yellow to light brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1758
- Product name
- PETCM
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $189
- Updated
- 2021/12/16
- Product number
- P999025
- Product name
- PETCM
- Packaging
- 1mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 256215
- Product name
- PETCM
- Packaging
- 50mg
- Price
- $475
- Updated
- 2021/12/16
- Product number
- A4420
- Product name
- PETCM
- Packaging
- 50mg
- Price
- $329
- Updated
- 2021/12/16
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Chemical Properties,Usage,Production
Uses
PETCM is a caspace-3 activator in cell extracts.
Definition
ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines.
Biological Activity
petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1].
storage
Room temperature
References
[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226.
ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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