ChemicalBook > CAS DataBase List > ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

Product Name: ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
CAS No.: 10129-56-3
Chemical Name: ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
Synonyms: PETCM;APOPTOSIS ACTIVATOR I;α-(Trichloromethyl)-4-pyridineethanol;a-(Trichloromethyl)-4-pyridineethanol;4-Pyridineethanol, α-(trichloromethyl)-;1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL;ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL;1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE;α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane
CBNumber: CB8197667
Molecular Formula: C8H8Cl3NO
Formula Weight: 240.51
MOL File: 10129-56-3.mol

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ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Property

Boiling point:: 342.2±37.0 °C(Predicted)
Density: 1.465±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO: 22 mg/mL, soluble
form: solid
pka: 12.07±0.20(Predicted)
color: Light yellow to light brown

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 1758
Product name: PETCM
Purity: ≥99%(HPLC)
Packaging: 50
Price: $189
Updated: 2021/12/16

TRC

Product number: P999025
Product name: PETCM
Packaging: 1mg
Price: $40
Updated: 2021/12/16

Usbiological

Product number: 256215
Product name: PETCM
Packaging: 50mg
Price: $475
Updated: 2021/12/16

ApexBio Technology

Product number: A4420
Product name: PETCM
Packaging: 50mg
Price: $329
Updated: 2021/12/16

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ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Chemical Properties,Usage,Production

Uses

PETCM is a caspace-3 activator in cell extracts.

Definition

ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines.

Biological Activity

petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1].

IC 50

Caspase 3

storage

Room temperature

References

[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226.

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Suppliers

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10129-56-3, ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOLRelated Search:

AC-LEU-GLU-HIS-ASP-AMC Z-PHE-DL-ALA-FLUOROMETHYLKETONE AC-VDVAD-PNA Z-VAD-FMK AC-YVAD-PNA CASPASE INHIBITOR3 AC-VEID-AMC Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Z-YVAD-AFC AC-VDVAD-CHO AC-DEVD-AFC PAC1 AC-DEVD-CHO AC-LEHD-AFC AC-LEU-GLU-THR-ASP-AFC 4-Pyridineethanol 4-(3-Chloropropyl)pyridine hydrochloride ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

PETCM

APOPTOSIS ACTIVATOR I

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

1-(4-PYRIDYL)-2-HYDROXY-3,3,3-TRICHLOROPROPANE

1,1,1-TRICHLORO-3-(4-PYRIDYL)PROPAN-2-OL

a-(Trichloromethyl)-4-pyridineethanol

α-(Trichloromethyl)-4-pyridineethanol

α-(Trichloromethyl)-4-pyridineethanol, 1-(4-Pyridyl)-2-hydroxy-3,3,3-trichloropropane

4-Pyridineethanol, α-(trichloromethyl)-

10129-56-3

C8H8Cl3NO

C8H8NOCl3

Cell Biology

Cell Signaling and Neuroscience

Apoptosis and Cell Cycle

Apoptosis Inducers

BioChemical

Caspase/Related products.