PAC1
- Product Name
- PAC1
- CAS No.
- 315183-21-2
- Chemical Name
- PAC1
- Synonyms
- PAC1;DUSP2;PAC1-R;CS-243;PAC1（b）;ADCYAP1R1;PAC-1,PAC1;PAC-1 10MG;PAC 1, >=98%;Pac1 receptor
- CBNumber
- CB71075505
- Molecular Formula
- C23H28N4O2
- Formula Weight
- 392.49
- MOL File
- 315183-21-2.mol
PAC1 Property
- Density
- 1.14
- storage temp.
- Store at +4°C
- solubility
- DMSO: ≥10mg/mL
- form
- solid
- pka
- 8.82±0.40(Predicted)
- color
- white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months.
Safety
- Hazard Codes
- Xn,N
- Risk Statements
- 22-36/37/38-50/53
- Safety Statements
- 26-36/37-60-61
- RIDADR
- UN 3077
- WGK Germany
- 3
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P0115
- Product name
- PAC-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- P0115
- Product name
- PAC-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- SAB1301755
- Product name
- ANTI-DUSP2 (C-TERM) antibody produced in rabbit
- Purity
- IgG fraction of antiserum, buffered aqueous solution
- Packaging
- 400μL
- Price
- $461
- Updated
- 2023/01/07
- Product number
- 10009317
- Product name
- PAC-1
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $108
- Updated
- 2024/03/01
- Product number
- 10009317
- Product name
- PAC-1
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $201
- Updated
- 2024/03/01
PAC1 Chemical Properties,Usage,Production
Description
PAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2?? Sensitizes cancer cells to various chemotherapeutic agents.3
Uses
PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.
Biological Activity
Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively).
storage
+4°C
References
1) Putt et al. (2006), Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy; Nat. Chem. Biol., 2 543 2) Peterson et al. (2009), PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition; J. Mol. Biol., 388 144 3) Bolham et al. (2016), Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with diverse Chemotherapeutics; ACS Cent. Sci., 2 545