ChemicalBook > CAS DataBase List > 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Product Name
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
CAS No.
79183-19-0
Chemical Name
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
Synonyms
CS-572;MDK83190;APOPTOSIS ACTIVATOR 2;APOPTOSIS ACTIVATOR II;MDK83190, 10 mM in DMSO;Apoptosis Activator 2, >=98%;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE;1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE USP/EP/BP
CBNumber
CB1755989
Molecular Formula
C15H9Cl2NO2
Formula Weight
306.14
MOL File
79183-19-0.mol
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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Property

Boiling point:
470.6±55.0 °C(Predicted)
Density 
1.494
Flash point:
238.4℃
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Soluble in DMSO
pka
-2.69±0.20(Predicted)
form 
Orange to red solid.
color 
Yellow to orange
Sensitive 
Light Sensitive
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Safety

Safety Statements 
24/25
RIDADR 
3077
HS Code 
29145090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10004176
Product name
Apoptosis Activator 2
Packaging
5mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
10004176
Product name
Apoptosis Activator 2
Packaging
10mg
Price
$66
Updated
2024/03/01
Cayman Chemical
Product number
10004176
Product name
Apoptosis Activator 2
Packaging
25mg
Price
$155
Updated
2024/03/01
Cayman Chemical
Product number
10004176
Product name
Apoptosis Activator 2
Packaging
50mg
Price
$274
Updated
2024/03/01
Tocris
Product number
2098
Product name
Apoptosis Activator 2
Purity
≥99%(HPLC)
Packaging
10
Price
$141
Updated
2021/12/16
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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Chemical Properties,Usage,Production

Uses

Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.

Uses

Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines

Definition

ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles.

Biological Activity

Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).

storage

Room temperature

References

[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22.

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Suppliers

China 132 Germany 2 India 2 Italy 1 Switzerland 1 United Kingdom 2 United States 23 Global 163
Shanghai Boyle Chemical Co., Ltd.
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Haoyuan Chemexpress Co., Ltd.
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-6206333 13167063860
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021-50323701
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anhua.mao@aladdin-e.com
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China
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View Lastest Price from 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE manufacturers

Career Henan Chemical Co
Product
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 79183-19-0
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

79183-19-0, 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONERelated Search:

N-METHYLISATIN Indole 1-ETHYL-1H-INDOLE-2,3-DIONE 1-(4-CHLORO-BENZYL)-1H-INDOLE-2,3-DIONE 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 1-BENZYL-1H-INDOLE-2,3-DIONE 1-(2,6-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-OXIME 1-(2,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 1-(2,6-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 5-CHLORO-1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 1-(2,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-[O-(2,4-DICHLOROBENZYL)OXIME] 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-OXIME 5-CHLORO-1-(2,6-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-[O-(2,6-DICHLOROBENZYL)OXIME] 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-[O-(4-CHLOROBENZYL)OXIME] 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-(N-[2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYL]HYDRAZONE) 1-(2,6-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-[O-(2,6-DICHLOROBENZYL)OXIME] 1-(2,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 3-OXIME

  • APOPTOSIS ACTIVATOR 2
  • APOPTOSIS ACTIVATOR II
  • 1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE
  • 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
  • 1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-
  • Apoptosis Activator 2, >=98%
  • Apoptosis Activator 2, 97%, a cytochrome c caspase activator and apoptosis inducer
  • CS-572
  • 1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione
  • MDK83190
  • 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE USP/EP/BP
  • Apoptosis Activator 2 (AAII), Cytochrome c caspase activator and apoptosis inducer
  • 1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione/Apoptosis Activator 2
  • MDK83190, 10 mM in DMSO
  • 79183-19-0
  • Inhibitors
  • Caspases/Apoptosis