1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
- Product Name
- 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
- CAS No.
- 79183-19-0
- Chemical Name
- 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
- Synonyms
- CS-572;MDK83190;APOPTOSIS ACTIVATOR 2;APOPTOSIS ACTIVATOR II;Apoptosis Activator 2, >=98%;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE;1-[(3,4-DICHLOROPHENYL)METHYL]-1H-INDOLE-2,3-DIONE;1H-Indole-2,3-dione, 1-[(3,4-dichlorophenyl)methyl]-;1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE USP/EP/BP;1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione
- CBNumber
- CB1755989
- Molecular Formula
- C15H9Cl2NO2
- Formula Weight
- 306.14
- MOL File
- 79183-19-0.mol
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Property
- Boiling point:
- 470.6±55.0 °C(Predicted)
- Density
- 1.494
- Flash point:
- 238.4℃
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Soluble in DMSO
- pka
- -2.69±0.20(Predicted)
- form
- Orange to red solid.
- Sensitive
- Light Sensitive
Safety
- Safety Statements
- 24/25
- RIDADR
- 3077
- HS Code
- 29145090
N-Bromosuccinimide Price
- Product number
- J65320
- Product name
- Apoptosis Activator 2
- Packaging
- 5mg
- Price
- $92.1
- Updated
- 2023/06/20
- Product number
- J65320
- Product name
- Apoptosis Activator 2
- Packaging
- 25mg
- Price
- $272
- Updated
- 2021/12/16
- Product number
- 10004176
- Product name
- Apoptosis Activator 2
- Packaging
- 5mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 10004176
- Product name
- Apoptosis Activator 2
- Packaging
- 10mg
- Price
- $66
- Updated
- 2024/03/01
- Product number
- 10004176
- Product name
- Apoptosis Activator 2
- Packaging
- 25mg
- Price
- $155
- Updated
- 2024/03/01
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Chemical Properties,Usage,Production
Uses
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.
Uses
Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines
Definition
ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles.
Biological Activity
Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).
storage
Room temperature
References
[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22.
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE manufacturers
- Product
- 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE 79183-19-0
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-09-03