ChemicalBook > CAS DataBase List > VeltuzuMab
VeltuzuMab
- Product Name
- VeltuzuMab
- CAS No.
- 728917-18-8
- Chemical Name
- VeltuzuMab
- Synonyms
- VeltuzuMab;Research Grade Veltuzumab;Research Grade Veltuzumab(DHC90711)
- CBNumber
- CB62658209
- Formula Weight
- 0
- MOL File
- Mol file
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VeltuzuMab Property
- form
- Liquid
- color
- Colorless to light yellow
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VeltuzuMab Chemical Properties,Usage,Production
Uses
Veltuzumab (IMMU-106) is a humanized anti-CD20 monoclonal antibody. Veltuzumab has low EC50 value of 0.08-0.09 μg/mL in the Daudi cell line. Veltuzumab can be used for the research of cancer including non-Hodgkin lymphoma (NHL)[1].
in vivo
Veltuzumab (i.v. or s.c.; 5, 20 and 60 μg; single) can control tumor growth or deplete circulating or sessile B cells at low doses in mouse models of intraperitoneal and subcutaneous doses[1].
Veltuzumab (i.p.; 0.05-35 μg) are significantly effective in vivo[1].
| Animal Model: | Lymphoma xenograft model[1] |
| Dosage: | 5, 20 and 60 μg |
| Administration: | intraperitoneal and subcutaneous, single |
| Result: | Showed low dose of 0.05 μg increased the MST. |
| Animal Model: | SCID mice[1] |
| Dosage: | 0.5, 0.25, 0.1, or 0.05 μg; 35, 3.5, 0.35, or 0.035 μg |
| Administration: | intraperitoneal, single |
| Result: | Improved significantly survival. |
References
[1] David M Goldenberg, et al. Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody. Blood DOI:10.1182/blood-2008-07-168146
VeltuzuMab Preparation Products And Raw materials
Raw materials
Preparation Products
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