Methyl 5-broMo-2-(difluoroMethoxy)benzoate

Product Name: Methyl 5-broMo-2-(difluoroMethoxy)benzoate
CAS No.: 1131587-78-4
Chemical Name: Methyl 5-broMo-2-(difluoroMethoxy)benzoate
Synonyms: Methyl 5-broMo-2-(difluoroMethoxy)benzoate;Benzoic acid, 5-bromo-2-(difluoromethoxy)-, methyl ester
CBNumber: CB62661410
Molecular Formula: C9H7BrF2O3
Formula Weight: 281.05
MOL File: 1131587-78-4.mol

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Methyl 5-broMo-2-(difluoroMethoxy)benzoate Property

Boiling point:: 291.5±35.0 °C(Predicted)
Density: 1.571±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature

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Safety

HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M295470
Product name: Methyl5-bromo-2-(difluoromethoxy)benzoate
Packaging: 1g
Price: $210
Updated: 2021/12/16

TRC

Product number: M295470
Product name: Methyl5-bromo-2-(difluoromethoxy)benzoate
Packaging: 250mg
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: 4720DF
Product name: Methyl5-bromo-2-(difluoromethoxy)benzoate
Packaging: 5g
Price: $608
Updated: 2021/12/16

Apolloscientific

Product number: PC520627
Product name: Methyl 5-bromo-2-(difluoromethoxy)benzoate
Packaging: 5g
Price: $713
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0036215
Product name: METHYL 5-BROMO-2-(DIFLUOROMETHOXY)BENZOATE
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

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Methyl 5-broMo-2-(difluoroMethoxy)benzoate Chemical Properties,Usage,Production

Synthesis

667-27-6

4068-76-2

1131587-78-4

To a solution of methyl 5-bromo-2-hydroxybenzoate (409 mg, 1.77 mmol) in anhydrous DMF (5 mL) was sequentially added potassium carbonate (367 mg, 2.67 mmol) and ethyl 2-bromo-2,2-difluoroacetate (280 μL, 2.13 mmol). The reaction mixture was stirred at 80 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature, diluted with ether (10 mL) and washed sequentially with water (10 mL), 10% aqueous hydrochloric acid solution (10 mL), water (10 mL) and saturated saline (10 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (elution gradient: n-hexane to n-hexane/ethyl acetate=2:1, v/v) to afford methyl 5-bromo-2-(difluoromethoxy)benzoate as a yellow oil (250 mg, 50% yield).

References

[1] Patent: WO2013/134562, 2013, A1. Location in patent: Paragraph 00294

Methyl 5-broMo-2-(difluoroMethoxy)benzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 5-broMo-2-(difluoroMethoxy)benzoate Suppliers

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Methyl 5-broMo-2-(difluoroMethoxy)benzoate

Benzoic acid, 5-bromo-2-(difluoromethoxy)-, methyl ester

1131587-78-4

1161587-78-4