360 A
- Product Name
- 360 A
- CAS No.
- 794458-56-3
- Chemical Name
- 360 A
- Synonyms
- 360A;360 A;360A;360 A;360A,Telomerase,inhibit,Inhibitor,G-quadruplex;3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium]
- CBNumber
- CB62666581
- Molecular Formula
- C27H23N5O2+2
- Formula Weight
- 449.50382
- MOL File
- 794458-56-3.mol
360 A Property
- storage temp.
- Store at -20°C
- solubility
- 25℃: DMSO
- form
- Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A3119
- Product name
- 360A
- Packaging
- 5mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- A3119
- Product name
- 360A
- Packaging
- 10mg
- Price
- $499
- Updated
- 2021/12/16
- Product number
- A3119
- Product name
- 360A
- Packaging
- 50mg
- Price
- $1170
- Updated
- 2021/12/16
- Product number
- CD31000782
- Product name
- 360A
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $162
- Updated
- 2021/12/16
- Product number
- CD31000782
- Product name
- 360A
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $249
- Updated
- 2021/12/16
360 A Chemical Properties,Usage,Production
Uses
360A is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.
References
[1] Pennarun G, et al. Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene. 2005 Apr 21;24(18):2917-28. DOI:10.1038/sj.onc.1208468
[2] Gauthier LR, et al. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci. 2012 Feb;69(4):629-40. DOI:10.1007/s00018-011-0767-6
360 A Preparation Products And Raw materials
Raw materials
Preparation Products
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