BMX-IN-1
- Product Name
- BMX-IN-1
- CAS No.
- 1431525-23-3
- Chemical Name
- BMX-IN-1
- Synonyms
- henyl]-;BMX-IN-1;BMX inhibitor 1;BMX-IN-1 USP/EP/BP;BMX kinase inhibitor;BMX-IN-1 (BMX kinase inhibitor;6]naphthyridin-1(2H)-yl)phenyl)acrylamide;N-(2-methyl-5-(9-(4-(methylsulfonamido)phenyl)-2-oxobenzo[h][1;inhibit,BMX Kinase,BMX IN 1,Bruton tyrosine kinase,Btk,Inhibitor,BMXIN1;N-(2-Methyl-5-(9-(4-(MethylsulfonaMido)phenyl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)phenyl)acrylaMide
- CBNumber
- CB62666602
- Molecular Formula
- C29H24N4O4S
- Formula Weight
- 524.59
- MOL File
- 1431525-23-3.mol
BMX-IN-1 Property
- Density
- 1.397±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥5.25 mg/mL in DMSO
- form
- solid
- pka
- 7.77±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5.05021
- Product name
- BMX-IN-1 - CAS 1431525-23-4 - Calbiochem
- Packaging
- 10mg
- Price
- $280
- Updated
- 2024/03/01
- Product number
- 19165
- Product name
- BMX-IN-1
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19165
- Product name
- BMX-IN-1
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 19165
- Product name
- BMX-IN-1
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 5123
- Product name
- BMX-IN-1
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $160
- Updated
- 2021/12/16
BMX-IN-1 Chemical Properties,Usage,Production
Description
BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC50 = 8 nM) that targets Cys496 in the BMX ATP binding domain. It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI50 value of 25 nM. Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI50s = 2.54, 4.38, 5.37, and 2.46 μM, respectively).
target
BMX Kinase
storage
Store at -20°C
BMX-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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