RGFP-966
- Product Name
- RGFP-966
- CAS No.
- 1357389-11-7
- Chemical Name
- RGFP-966
- Synonyms
- CS-871;RGFP966;RGFP-966;RGFP 966;(E/Z)-RGFP 966;RGFP966, >=98%;RGFP966; RGFP-966;RGFP966, 10 mM in DMSO;RGFP 966, HDAC3 inhibitor;(2E)-N-(2-Amino-4-fluorophenyl)-3-(1-(3-phenylallyl)-1H-pyrazol-4-yl)acrylamide
- CBNumber
- CB62666682
- Molecular Formula
- C21H19FN4O
- Formula Weight
- 362.4
- MOL File
- 1357389-11-7.mol
RGFP-966 Property
- Boiling point:
- 630.4±55.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 20 mg/ml)
- form
- solid
- pka
- 11.58±0.70(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChI
- InChI=1S/C21H19FN4O/c22-18-9-10-20(19(23)13-18)25-21(27)11-8-17-14-24-26(15-17)12-4-7-16-5-2-1-3-6-16/h1-11,13-15H,12,23H2,(H,25,27)/b7-4,11-8+
- InChIKey
- BLVQHYHDYFTPDV-WPGSJKDTSA-N
- SMILES
- C(NC1=CC=C(F)C=C1N)(=O)/C=C/C1=CN(CC=CC2=CC=CC=C2)N=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16917
- Product name
- RGFP966
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $31
- Updated
- 2024/03/01
- Product number
- 16917
- Product name
- RGFP966
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 16917
- Product name
- RGFP966
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- R314710
- Product name
- (E/Z)-RGFP966
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-1628
- Product name
- RGFP966
- Purity
- 99.81%
- Packaging
- 10mg
- Price
- $168
- Updated
- 2021/12/16
RGFP-966 Chemical Properties,Usage,Production
Description
RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50= 80 nM, no other HDACs inhibited @ 15μM).1It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.1-5
Uses
(E)-RGFP 966 is a histone deacetylase 3 (HDAC3) inhibitor.
Definition
ChEBI: N-(2-amino-4-fluorophenyl)-3-[1-(3-phenylprop-2-enyl)-4-pyrazolyl]-2-propenamide is an aromatic amide and an aromatic amine.
target
HDAC3
storage
Store at -20°C
References
[1] MELISSA MALVAEZ. HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner.[J]. ACS Catalysis , 2013: 2647-2652. DOI:10.1073/pnas.1213364110
[2] KASIA M BIESZCZAD. Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation.[J]. Journal of Neuroscience, 2015, 35 38: 13124-13132. DOI:10.1523/jneurosci.0914-15.2015
[3] XIAOLEI ZHU. HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer’s disease[J]. Aging Cell, 2017, 16 5: 1073-1082. DOI:10.1111/acel.12642
[4] HAIQUN JIA. The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington’s Disease Mice[J]. PLoS ONE, 2016, 11 1. DOI:10.1371/journal.pone.0152498
[5] KAROLINA J JANCZURA. Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 47: E11148-E11157. DOI:10.1073/pnas.1805436115
RGFP-966 Preparation Products And Raw materials
Raw materials
Preparation Products
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