RGFP-966
- Product Name
- RGFP-966
- CAS No.
- 1357389-11-7
- Chemical Name
- RGFP-966
- Synonyms
- CS-871;RGFP966;RGFP-966;RGFP 966;(E/Z)-RGFP 966;RGFP966, >=98%;RGFP966; RGFP-966;RGFP966, 10 mM in DMSO;RGFP 966, HDAC3 inhibitor;(2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
- CBNumber
- CB62666682
- Molecular Formula
- C21H19FN4O
- Formula Weight
- 362.4
- MOL File
- 1357389-11-7.mol
RGFP-966 Property
- Boiling point:
- 630.4±55.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 20 mg/ml)
- form
- solid
- pka
- 11.58±0.70(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
N-Bromosuccinimide Price
- Product number
- 16917
- Product name
- RGFP966
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $31
- Updated
- 2024/03/01
- Product number
- 16917
- Product name
- RGFP966
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 16917
- Product name
- RGFP966
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- R314710
- Product name
- (E/Z)-RGFP966
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-1628
- Product name
- RGFP966
- Purity
- 99.81%
- Packaging
- 10mg
- Price
- $168
- Updated
- 2021/12/16
RGFP-966 Chemical Properties,Usage,Production
Description
RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50?= 80 nM, no other HDACs inhibited @ 15μM).1?It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.1-5
Uses
(E)-RGFP 966 is a histone deacetylase 3 (HDAC3) inhibitor.
Definition
ChEBI: N-(2-amino-4-fluorophenyl)-3-[1-(3-phenylprop-2-enyl)-4-pyrazolyl]-2-propenamide is an aromatic amide and an aromatic amine.
target
HDAC3
storage
Store at -20°C
References
1) Malvaez?et al.?(2013),?HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner; Proc. Natl. Acad. Sci. USA?110?2647 2) Bieszczad?et al.?(2015),?Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation; J. Neurosci.?35?13124 3) Zhu?et al.?(2017),?HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer’s disease; Aging Cell?16?1073 4) Haiqun?et al. (2016),?The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3)in Huntington’s Disease Mice; PLoS One 0152498 5) Janczura?et al.?(2018),?Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model; Proc. Natl. Acad. Sci. USA?115?E11148
RGFP-966 Preparation Products And Raw materials
Raw materials
Preparation Products
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