RGFP-966

Product Name: RGFP-966
CAS No.: 1357389-11-7
Chemical Name: RGFP-966
Synonyms: CS-871;RGFP966;RGFP-966;RGFP 966;(E/Z)-RGFP 966;RGFP966, >=98%;RGFP966; RGFP-966;RGFP966, 10 mM in DMSO;RGFP 966, HDAC3 inhibitor;(2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
CBNumber: CB62666682
Molecular Formula: C21H19FN4O
Formula Weight: 362.4
MOL File: 1357389-11-7.mol

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RGFP-966 Property

Boiling point:: 630.4±55.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 20 mg/ml)
form: solid
pka: 11.58±0.70(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16917
Product name: RGFP966
Purity: ≥98%
Packaging: 1mg
Price: $31
Updated: 2024/03/01

Cayman Chemical

Product number: 16917
Product name: RGFP966
Purity: ≥98%
Packaging: 5mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 16917
Product name: RGFP966
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

TRC

Product number: R314710
Product name: (E/Z)-RGFP966
Packaging: 1mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-1628
Product name: RGFP966
Purity: 99.81%
Packaging: 10mg
Price: $168
Updated: 2021/12/16

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RGFP-966 Chemical Properties,Usage,Production

Description

RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50?= 80 nM, no other HDACs inhibited @ 15μM).1?It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.1-5

Uses

(E)-RGFP 966 is a histone deacetylase 3 (HDAC3) inhibitor.

Definition

ChEBI: N-(2-amino-4-fluorophenyl)-3-[1-(3-phenylprop-2-enyl)-4-pyrazolyl]-2-propenamide is an aromatic amide and an aromatic amine.

target

HDAC3

storage

Store at -20°C

References

1) Malvaez?et al.?(2013),?HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner; Proc. Natl. Acad. Sci. USA?110?2647 2) Bieszczad?et al.?(2015),?Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation; J. Neurosci.?35?13124 3) Zhu?et al.?(2017),?HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer’s disease; Aging Cell?16?1073 4) Haiqun?et al. (2016),?The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3)in Huntington’s Disease Mice; PLoS One 0152498 5) Janczura?et al.?(2018),?Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model; Proc. Natl. Acad. Sci. USA?115?E11148

RGFP-966 Preparation Products And Raw materials

Raw materials

Preparation Products

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RGFP-966 Suppliers

China 90 United States 14 Global 104

Target molecule Corp.

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1357389-11-7, RGFP-966Related Search:

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RGFP 966

RGFP966

RGFP-966

(2E)-N-(2-Amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide

RGFP966, >=98%

(E/Z)-RGFP 966

RGFP966; RGFP-966

CS-871

2-Propenamide, N-(2-amino-4-fluorophenyl)-3-[1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-, (2E)-

RGFP 966, HDAC3 inhibitor

RGFP966, 10 mM in DMSO

1357389-11-7

Inhibitors