ChemicalBook > CAS DataBase List > XMD17 109
XMD17 109
- Product Name
- XMD17 109
- CAS No.
- 1435488-37-1
- Chemical Name
- XMD17 109
- Synonyms
- CS-1288;XMD17-109;XMD17 109;XMD17 109;XMD17109;XMD17-109, 10 mM in DMSO;11-Cyclopentyl-2-[2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5-methylpyrimido[4,5-b][1,4]benzodiazepin-6-one;11-Cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;11-Cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-piperazin-1-yl)piperidin-1-yl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 11-cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-;11-Cyclopentyl-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one XMD17-109
- CBNumber
- CB62666703
- Molecular Formula
- C36H46N8O3
- Formula Weight
- 638.8
- MOL File
- 1435488-37-1.mol
More
Less
XMD17 109 Property
- storage temp.
- -20°C
- solubility
- ≥31.95 mg/mL in DMSO; insoluble in H2O; ≥86.6 mg/mL in EtOH
- form
- powder
- color
- white to beige
- InChIKey
- XVBGRTMNFNMINE-UHFFFAOYSA-N
- SMILES
- N7(CCN(CC7)C)C1CCN(CC1)C(=O)c2cc(c(cc2)Nc3nc4[n](c6c([c]([n](c4cn3)C)=O)cccc6)C5CCCC5)OCC
More
Less
Safety
- WGK Germany
- WGK 3
- HS Code
- 2933599590
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1753
- Product name
- XMD17-109
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $136
- Updated
- 2026/04/30
Sigma-Aldrich
- Product number
- SML1753
- Product name
- XMD17-109
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $542
- Updated
- 2023/01/07
Cayman Chemical
- Product number
- 25448
- Product name
- XMD17-109
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2026/04/30
Cayman Chemical
- Product number
- 25448
- Product name
- XMD17-109
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $132
- Updated
- 2026/04/30
Cayman Chemical
- Product number
- 25448
- Product name
- XMD17-109
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $246
- Updated
- 2026/04/30
More
Less
XMD17 109 Chemical Properties,Usage,Production
Uses
ERK5-IN-1 is a potent selective ERK5 inhibitor, inhibiting EGFR-induced ERK5 autophosphorylation and ERK5 enzymatic activity. Orally bioavailable.
Biological Activity
xmd17-109 is a new inhibitor of erk5, ic50 value in hela cell is 0.09 ± 0.03 μm, and in vitro, enzymatic ic50 value is 0.162 ± 0.006 μm.xmd17-109 is capable of inhibiting the erk5 autophosphorylation in cells.[1]through intravenous injection and oral delivery of xmd17-109 in mice, the pharmacokinetic properties of this compound are as bellows: the t1/2 (half time) is 8.2 h, the plasma clearance is 8.64 ml/min/kg (data of intravenous injection), the auc (area under the curve) of oral delivery is 15745 h*ng/ml and the oral bioavailability is 90%.
IC 50
ERK5: 162 nM (IC50); LRRK2[G2019S]: 339 nM (IC50)
storage
Store at -20°C
References
1. deng, x., et al., structural determinants for erk5 (mapk7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11h)-ones. european journal of medicinal chemistry, 2013. 70: p. 758-767.
XMD17 109 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
XMD17 109 Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 21-57721279 18121011378
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 998
- Advantage
- 56
- Tel
- 025-83697070 13770331960
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16059
- Advantage
- 64
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- +86-21-38682181 15900741819
- Fax
- +86-21-38682181
- Country
- China
- ProdList
- 282
- Advantage
- 55
- Tel
- 13816107857
- Fax
- qq: 276312098
- sales@fortunechem-sh.com
- Country
- China
- ProdList
- 983
- Advantage
- 58
- Tel
- 0551-66399836 18955197623
- sales@enlipharma.com
- Country
- China
- ProdList
- 1876
- Advantage
- 55
- Tel
- Mobile:13665161512
- Fax
- +86-510-68873513
- Country
- China
- ProdList
- 1785
- Advantage
- 58
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39999
- Advantage
- 60
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
1435488-37-1, XMD17 109Related Search:
6H-PyriMido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-5,11-diMethyl-
XMD17-51
XMD16-5
ACK1-B19
XMD-17-51 Trifluoroacetate
2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-5,11-dimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-, 2,2,2-trifluoroacetate (1:1)
6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-, 2,2,2-trifluoroacetate (1:1)