FG 2216

Product Name: FG 2216
CAS No.: 223387-75-5
Chemical Name: FG 2216
Synonyms: BIQ;IOX-3;YM 311;FG2216;FG-2216;FG 2216;CS-1687;FG-2216(IOX3;FG-2216 - YM 311;FG2216;FG-2216;FG 2216
CBNumber: CB62666905
Molecular Formula: C12H9ClN2O4
Formula Weight: 280.66
MOL File: 223387-75-5.mol

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FG 2216 Property

Boiling point:: 670.6±55.0 °C(Predicted)
Density: 1.571±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥5.12 mg/mL in EtOH with ultrasonic
form: powder
pka: 3.20±0.10(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1811
Product name: BIQ
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $159
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1811
Product name: BIQ
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $639
Updated: 2024/03/01

Cayman Chemical

Product number: 18382
Product name: FG-2216
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18382
Product name: FG-2216
Purity: ≥98%
Packaging: 5mg
Price: $140
Updated: 2024/03/01

Cayman Chemical

Product number: 18382
Product name: FG-2216
Purity: ≥98%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

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FG 2216 Chemical Properties,Usage,Production

Description

FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC₅₀ = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 μM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.

Uses

FG 2216 is an erythropoietic agent which is orally active prolyl-hydroxylase inhibitor which increases erythropoietin production in end-stage kidney disease.

Biochem/physiol Actions

BIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD). BIQ induces significant and reversible plasma erythropoietin (EPO) levels in vitro and in hemodialysis patients.

References

1. hsieh mm, linde ns, wynter a et al. hif prolyl hydroxylase inhibitionresults in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. blood. 2007 sep 15;110(6):2140-7.

FG 2216 Preparation Products And Raw materials

Raw materials

Preparation Products

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FG 2216 Suppliers

China 66 India 2 United Kingdom 1 United States 14 Global 83

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7856
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 993
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

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View Lastest Price from FG 2216 manufacturers

Career Henan Chemical Co

Product: FG 2216 223387-75-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

223387-75-5, FG 2216Related Search:

FG 2216

FG2216

FG-2216

[[(1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl]amino]acetic acid

FG 2216 (erythropoietic agent)

YM 311

(Z)-2-(((1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)(HYDROXY)METHYLENE)AMINO)ACETIC ACID

N-[(1-Chloro-4-hydroxy-3-isoquinolinyl)carbonyl]glycine

(N-(1-chloro-4-hydroxy-isoquinoline-3-carbonyl)-amino)-acetic acid

FG2216;FG-2216;FG 2216

Glycine, N-[(1-chloro-4-hydroxy-3-isoquinolinyl)carbonyl]-

CS-1687

FG-2216(IOX3

FG-2216 - YM 311

BIQ

2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)acetic acid

(1-Chloro-4-hydroxyisoquinoline-3-carbonyl)glycine

IOX-3

223387-75-5

Inhibitors