FG 2216
- Product Name
- FG 2216
- CAS No.
- 223387-75-5
- Chemical Name
- FG 2216
- Synonyms
- BIQ;IOX-3;YM 311;FG2216;FG-2216;FG 2216;CS-1687;FG-2216(IOX3;FG-2216 - YM 311;FG2216;FG-2216;FG 2216
- CBNumber
- CB62666905
- Molecular Formula
- C12H9ClN2O4
- Formula Weight
- 280.66
- MOL File
- 223387-75-5.mol
FG 2216 Property
- Boiling point:
- 670.6±55.0 °C(Predicted)
- Density
- 1.571±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- insoluble in H2O; ≥14.05 mg/mL in DMSO; ≥5.12 mg/mL in EtOH with ultrasonic
- form
- powder
- pka
- 3.20±0.10(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1811
- Product name
- BIQ
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- SML1811
- Product name
- BIQ
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $639
- Updated
- 2024/03/01
- Product number
- 18382
- Product name
- FG-2216
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18382
- Product name
- FG-2216
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $140
- Updated
- 2024/03/01
- Product number
- 18382
- Product name
- FG-2216
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $257
- Updated
- 2024/03/01
FG 2216 Chemical Properties,Usage,Production
Description
FG-2216 is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 3.9 micromolar). It has been shown to reversibly stimulate erythropoietin secretion at 100 μM in vitro and to increase hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.
Uses
FG 2216 is an erythropoietic agent which is orally active prolyl-hydroxylase inhibitor which increases erythropoietin production in end-stage kidney disease.
Biochem/physiol Actions
BIQ (FG-2216) is an orally available and potent inhibitor of prolyl-hydroxylase (PHD). BIQ induces significant and reversible plasma erythropoietin (EPO) levels in vitro and in hemodialysis patients.
References
1. hsieh mm, linde ns, wynter a et al. hif prolyl hydroxylase inhibitionresults in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. blood. 2007 sep 15;110(6):2140-7.
FG 2216 Preparation Products And Raw materials
Raw materials
Preparation Products
FG 2216 Suppliers
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- 86-21-57758967
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- +86-21-61629029
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- China
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- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
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- 021-61415566 800-8193336
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- China
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- Tel
- Fax
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- Country
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View Lastest Price from FG 2216 manufacturers
- Product
- FG 2216 223387-75-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23