SKLB 610
- Product Name
- SKLB 610
- CAS No.
- 1125780-41-7
- Chemical Name
- SKLB 610
- Synonyms
- CS-913;SKLB 710;SKLB 610;SKLB 610, >=98%;SKLB 610; SKLB-610;N-METHYL-4-(4-(3-(TRIFLUOROMETHYL)BENZAMIDO)PHENOXY)PICOLINAMIDE;N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide;N-methyl-4-[4-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]pyridine-2-carboxamide;2-Pyridinecarboxamide, N-methyl-4-[4-[[3-(trifluoromethyl)benzoyl]amino]phenoxy]-;N-Methyl-4-[4-[3-(trifluoromethyl)benzamido]phenoxy]-2-picolinamide SKLB 610
- CBNumber
- CB62667038
- Molecular Formula
- C21H16F3N3O3
- Formula Weight
- 415.37
- MOL File
- 1125780-41-7.mol
SKLB 610 Property
- Boiling point:
- 500.9±50.0 °C(Predicted)
- Density
- 1.357±0.06 g/cm3(Predicted)
- storage temp.
- Store at 4°C
- solubility
- insoluble in H2O; ≥20.75 mg/mL in DMSO; ≥23 mg/mL in EtOH with ultrasonic
- form
- solid
- pka
- 12.23±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
N-Bromosuccinimide Price
- Product number
- 21561
- Product name
- SKLB 610
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21561
- Product name
- SKLB 610
- Packaging
- 5mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 21561
- Product name
- SKLB 610
- Packaging
- 10mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- 21561
- Product name
- SKLB 610
- Packaging
- 25mg
- Price
- $571
- Updated
- 2024/03/01
- Product number
- orb181323
- Product name
- SKLB610
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1060.8
- Updated
- 2021/12/16
SKLB 610 Chemical Properties,Usage,Production
Biological Activity
sklb610 is a selective inhibitor of vegfr with ic50 value of 2.2 μm [1].vegfr (vascular endothelial growth factor receptor) are receptors for vegf and plays an important role in stimulating cellular response by cooperating with vegf. it has been reported that vegfr abnormally expressed in a variety of cancers and its inhibitors has been regarded as a promising strategy in clinic [1, 2].sklb610 is a potent vegf induced vegf2 phosphorylation inhibitor. when tested with a panel of human cancer cell lines, sklb610 inhibited cell proliferation with ic50 value ranges from 2.2 μm to 25.6 μm. in huvecs, sklb610 showed inhibition on vegf-stimulated cell proliferation as well as vegfr2 phosphorylation, inhibited cell capillary tube formation in a dose-dependent manner [1]. the solubility of sklb610 in water, ethanol, ethyl acetate, 0.5% tween 80 and nanosuspension is 0.34 μg/ml, 16500 μg/ml, 380μg/ml, 23μg/ml and 103μg/ml [2, 3].in mouse model with hct116 subcutaneous xenograft, administration of sklb610 (12.5 mg/kg, 25 mg/kg and 50 mg/kg) for 10 days markedly delayed tumor growth in a concentration dependent manner. further, after 30 days treatment sklb610significantly suppressed tumor volume as 77.1 % at the dose of 50 mg/kg [1].
target
FGFR
References
[1]. cao, z.x., et al., sklb610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo. cell physiol biochem, 2011. 27(5): p. 565-74.
[2]. luo, x., et al., pharmacokinetic studies of a novel multikinase inhibitor for treating cancer by hplc-uv. j chromatogr sci, 2013. 51(1): p. 17-20.
[3]. huang, y., et al., the preparation and evaluation of water-soluble sklb610 nanosuspensions with improved bioavailability. aaps pharmscitech, 2013. 14(3): p. 1236-43.
SKLB 610 Preparation Products And Raw materials
Raw materials
Preparation Products
SKLB 610 Suppliers
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View Lastest Price from SKLB 610 manufacturers
- Product
- SKLB 610 1125780-41-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-08-08