ChemicalBook > CAS DataBase List > AVN-944

AVN-944

Product Name
AVN-944
CAS No.
297730-17-7
Chemical Name
AVN-944
Synonyms
VX944;VX 944;VX-944;CS-1604;AVN944 (VX-944);VX 944; AVN-944;;(R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate;[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate;Carbamic acid, N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]-, (1R)-1-(cyanomethyl)propyl ester;multiple myeloma,RPMI8226,Caspase,AVN-944,VX 944,Apoptosis,BMSCs,IMPDH,Arenavirus,Bcl-2 Family,U266 cells,inhibit,DNA/RNA Synthesis,acute myeloid leukemia,AML,MM.1S,AVN944,oncolytic activity,Inhibitor,AIF,Endo G,VX944,caspase-independent,AVN 944
CBNumber
CB62668095
Molecular Formula
C25H27N5O5
Formula Weight
477.51
MOL File
297730-17-7.mol
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AVN-944 Property

Boiling point:
597.4±50.0 °C(Predicted)
Density 
1.277±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.52(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.83(Max Conc. mM)
form 
A crystalline solid
pka
11.38±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3440
Product name
AVN-944
Purity
≥98% (HPLC)
Packaging
5MG
Price
$79
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3440
Product name
AVN-944
Purity
≥98% (HPLC)
Packaging
25MG
Price
$319
Updated
2024/03/01
Cayman Chemical
Product number
21284
Product name
AVN944
Purity
≥98%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
21284
Product name
AVN944
Purity
≥98%
Packaging
5mg
Price
$111
Updated
2024/03/01
Cayman Chemical
Product number
21284
Product name
AVN944
Purity
≥98%
Packaging
10mg
Price
$184
Updated
2024/03/01
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AVN-944 Chemical Properties,Usage,Production

Description

AVN944 is a selective, noncompetitive inhibitor of inosine-5''-monophosphate dehydrogenase (IMPDH; Ki = 6-10 nM for both human IMPDH isoforms), a rate-limiting enzyme involved in the de novo synthesis of purine nucleotides. Inhibition of IMPDH results in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 has been shown to inhibit the proliferation of multiple myeloma cells in vitro by inducing caspase-independent apoptosis. It is also reported to have antitumor properties in androgen-sensitive and androgen-independent prostate cancer cells in vitro.

Uses

AVN-944 is a novel inosine monophosphate dehydrogenase (IMPDH) inhibitor. It has antiproliferative effects and might be combined with other agents for treatment of human prostate cancer.This compound is suitable for pyruvate dehydrogenase (PDH) related research.

Enzyme inhibitor

This orally available antineoplastic agent (FW = 310.36 g/mol; CAS 297730-17-7), also known as VX-944 and (R)-1-cyanobutan-2-yl-(S)-1-(3- (3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate, inhibits inosine 5’-monophosphate dehydrogenase (IMPDH), the enzyme catalyzing the conversion of IMP into XMP, leading to the biosynthesis of GMP, GDP, GTP, and ultimately dGTP. IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies, and AVN944 appears to have a selective cytotoxic effect on cancer cells. Reduction of GTP in normal cells results in a temporary slowing of cell growth only.AVN944 treatment results in dose-dependent cell growth inhibition in all studied prostate cancer cells, independently of their androgen sensitivity. AVN944 treatment arrests LNCaP cells in G1-phase and and androgen independent 22Rv1, DU145 and PC-3 cells in S-phase. AVN-944 treatment leads to the rapid disappearance of nucleostemin, a positive regulator of cell proliferation that is highly expressed in a variety of stem cells, tumors, and tumor cell lines.

AVN-944 Preparation Products And Raw materials

Raw materials

Preparation Products

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AVN-944 Suppliers

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View Lastest Price from AVN-944 manufacturers

Career Henan Chemical Co
Product
[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate 297730-17-7
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

297730-17-7, AVN-944Related Search:

VX-745 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide VE 822 Telaprevir VX-770 Pimodivir

  • VX 944
  • VX944
  • VX-944
  • AVN944 (VX-944)
  • (R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate
  • VX 944; AVN-944;
  • CS-1604
  • [(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate
  • Carbamic acid, N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]-, (1R)-1-(cyanomethyl)propyl ester
  • multiple myeloma,RPMI8226,Caspase,AVN-944,VX 944,Apoptosis,BMSCs,IMPDH,Arenavirus,Bcl-2 Family,U266 cells,inhibit,DNA/RNA Synthesis,acute myeloid leukemia,AML,MM.1S,AVN944,oncolytic activity,Inhibitor,AIF,Endo G,VX944,caspase-independent,AVN 944
  • 297730-17-7
  • Inhibitors