AVN-944

ChemicalBook > CAS DataBase List > AVN-944

Product Name: AVN-944
CAS No.: 297730-17-7
Chemical Name: AVN-944
Synonyms: VX944;VX 944;VX-944;CS-1604;AVN944 (VX-944);VX 944; AVN-944;;(R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate;[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate;Carbamic acid, N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]-, (1R)-1-(cyanomethyl)propyl ester;multiple myeloma,RPMI8226,Caspase,AVN-944,VX 944,Apoptosis,BMSCs,IMPDH,Arenavirus,Bcl-2 Family,U266 cells,inhibit,DNA/RNA Synthesis,acute myeloid leukemia,AML,MM.1S,AVN944,oncolytic activity,Inhibitor,AIF,Endo G,VX944,caspase-independent,AVN 944
CBNumber: CB62668095
Molecular Formula: C25H27N5O5
Formula Weight: 477.51
MOL File: 297730-17-7.mol

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AVN-944 Property

Boiling point:: 597.4±50.0 °C(Predicted)
Density: 1.277±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.52(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.83(Max Conc. mM)
form: A crystalline solid
pka: 11.38±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3440
Product name: AVN-944
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $79
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3440
Product name: AVN-944
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $319
Updated: 2024/03/01

Cayman Chemical

Product number: 21284
Product name: AVN944
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 21284
Product name: AVN944
Purity: ≥98%
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 21284
Product name: AVN944
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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AVN-944 Chemical Properties,Usage,Production

Description

AVN944 is a selective, noncompetitive inhibitor of inosine-5''-monophosphate dehydrogenase (IMPDH; K_i = 6-10 nM for both human IMPDH isoforms), a rate-limiting enzyme involved in the de novo synthesis of purine nucleotides. Inhibition of IMPDH results in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 has been shown to inhibit the proliferation of multiple myeloma cells in vitro by inducing caspase-independent apoptosis. It is also reported to have antitumor properties in androgen-sensitive and androgen-independent prostate cancer cells in vitro.

Uses

AVN-944 is a novel inosine monophosphate dehydrogenase (IMPDH) inhibitor. It has antiproliferative effects and might be combined with other agents for treatment of human prostate cancer.This compound is suitable for pyruvate dehydrogenase (PDH) related research.

Enzyme inhibitor

This orally available antineoplastic agent (FW = 310.36 g/mol; CAS 297730-17-7), also known as VX-944 and (R)-1-cyanobutan-2-yl-(S)-1-(3- (3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate, inhibits inosine 5’-monophosphate dehydrogenase (IMPDH), the enzyme catalyzing the conversion of IMP into XMP, leading to the biosynthesis of GMP, GDP, GTP, and ultimately dGTP. IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies, and AVN944 appears to have a selective cytotoxic effect on cancer cells. Reduction of GTP in normal cells results in a temporary slowing of cell growth only.AVN944 treatment results in dose-dependent cell growth inhibition in all studied prostate cancer cells, independently of their androgen sensitivity. AVN944 treatment arrests LNCaP cells in G1-phase and and androgen independent 22Rv1, DU145 and PC-3 cells in S-phase. AVN-944 treatment leads to the rapid disappearance of nucleostemin, a positive regulator of cell proliferation that is highly expressed in a variety of stem cells, tumors, and tumor cell lines.

AVN-944 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AVN-944 manufacturers

Career Henan Chemical Co

Product: [(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate 297730-17-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-01

297730-17-7, AVN-944Related Search:

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VX 944

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AVN944 (VX-944)

(R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate

VX 944; AVN-944;

CS-1604

[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate

Carbamic acid, N-[(1S)-1-[3-[[[[3-methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]ethyl]-, (1R)-1-(cyanomethyl)propyl ester

multiple myeloma,RPMI8226,Caspase,AVN-944,VX 944,Apoptosis,BMSCs,IMPDH,Arenavirus,Bcl-2 Family,U266 cells,inhibit,DNA/RNA Synthesis,acute myeloid leukemia,AML,MM.1S,AVN944,oncolytic activity,Inhibitor,AIF,Endo G,VX944,caspase-independent,AVN 944

297730-17-7

Inhibitors