(+/-)-EvodiaMine

Product Name: (+/-)-EvodiaMine
CAS No.: 518-18-3
Chemical Name: (+/-)-EvodiaMine
Synonyms: (±)-Evodiamine;(+/-)-Evodiamine;(+/-)-Evodiamine>TXDUTHBFYKGSAH-UHFFFAOYSA-N;14-Methyl-7,8,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(13H)-one
CBNumber: CB62673316
Molecular Formula: C19H17N3O
Formula Weight: 303.36
MOL File: 518-18-3.mol

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(+/-)-EvodiaMine Property

Melting point:: 272°C(lit.)
Boiling point:: 575.1±50.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: 0-10°C
solubility: very slightly in Acetone
form: powder to crystal
pka: 17.27±0.20(Predicted)
color: White to Orange to Green
λmax: 268nm(EtOH)(lit.)

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Safety

HS Code: 2939.80.0000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1012
Product name: (+/-)-Evodiamine
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $123
Updated: 2025/07/31

TRC

Product number: E975133
Product name: (+/-)-Evodiamine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Chem-Impex

Product number: 32473
Product name: (±)-Evodiamine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 250MG
Price: $56
Updated: 2021/12/16

Chem-Impex

Product number: 32473
Product name: (±)-Evodiamine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 1G
Price: $100.8
Updated: 2021/12/16

Chem-Impex

Product number: 32473
Product name: (±)-Evodiamine,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 5G
Price: $476
Updated: 2021/12/16

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(+/-)-EvodiaMine Chemical Properties,Usage,Production

Description

Evodiamine is extracted and isolated from the fruit of Evodiarutaecarpa (Juss.) Benth., a rutaceae plant. It is converted into Isoevodiamine after being boiled with hydrochloric acid alcohol solution.

Uses

(±)-Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±)-Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their apoptosis[1].

Definition

ChEBI: LSM-6483 is a member of beta-carbolines.

Pharmacokinetics

1. Antitumor activity
Evodiamine can inhibit the proliferation of various tumor cells, including cervical cancer, colon cancer, lung cancer, melanoma, T lymphocyte-like leukemia, prostate cancer Inhibition of proliferation of various tumor cells including cancer and breast cancer.
2. Anti-senile dementia effect

3. Effects on endocrine system
Evodiamine can inhibit 3β-hydroxysteroid dehydrogenase by reducing the activity of intracellular cyclic adenosine monophosphate (cAMP) related pathways (3β-HSD) and other steroid hormone production-related enzymes, reduce and affect the expression of signal transduction and RNA activation protein (StAR), and directly act on rat adrenal cortex reticulum cells to inhibit the secretion of corticosterone.
4. Weight loss and hypoglycemic effect
5.Anti-inflammatory and analgesic effect

6. Effects on the cardiovascular system

IC 50

Top1

References

[1] Dong G, et, al. New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations. J Med Chem. 2012 Sep 13;55(17):7593-613. DOI:10.1021/jm300605m

(+/-)-EvodiaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-)-EvodiaMine Suppliers

Americas 1 China 35 Europe 1 India 1 Japan 1 United States 3 Global 42

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518-18-3, (+/-)-EvodiaMineRelated Search:

TXDUTHBFYKGSAH-UHFFFAOYSA-N

(+/-)-Evodiamine&gt

(+/-)-Evodiamine

14-Methyl-7,8,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(13H)-one

(±)-Evodiamine

518-18-3