ChemicalBook > CAS DataBase List > 2-Bromo-5-hydroxypyrazine

2-Bromo-5-hydroxypyrazine

Uses

Product Name: 2-Bromo-5-hydroxypyrazine
CAS No.: 374063-92-0
Chemical Name: 2-Bromo-5-hydroxypyrazine
Synonyms: 5-Bromopyrazin-2;5-bromopyrazin-2-o;5-bromopyrazin-2-ol;5-BROMO-2-PYRAZINOL;5-Bromopyrazin-2(1H)-one;5-bromo-1H-pyrazin-2-one;5-Bromo-2(1H)-pyrazinone;2-hydroxy-5-bromopyrazine;5-BROMO-2-HYDROXYPYRAZINE;2-BROMO-5-HYDROXY-PYRAZINE
CBNumber: CB6267582
Molecular Formula: C4H3BrN2O
Formula Weight: 174.98
MOL File: 374063-92-0.mol

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2-Bromo-5-hydroxypyrazine Property

Melting point:: 115-119°C
Density: 2.00±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 10.02±0.40(Predicted)
form: Crystalline Powder
color: White to light brown
InChI: InChI=1S/C4H3BrN2O/c5-3-1-7-4(8)2-6-3/h1-2H,(H,7,8)
InChIKey: ITTXBHQAWOFJAI-UHFFFAOYSA-N
SMILES: C1(=O)NC=C(Br)N=C1

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 1
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 709735
Product name: 2-Bromo-5-hydroxypyrazine
Purity: 95%
Packaging: 250mg
Price: $56.4
Updated: 2025/07/31

TCI Chemical

Product number: B3881
Product name: 2-Bromo-5-hydroxypyrazine
Purity: >95.0%(GC)
Packaging: 1g
Price: $525
Updated: 2024/03/01

TCI Chemical

Product number: B3881
Product name: 2-Bromo-5-hydroxypyrazine
Purity: >95.0%(GC)
Packaging: 200mg
Price: $153
Updated: 2024/03/01

TRC

Product number: B686183
Product name: 5-Bromo-1H-pyrazin-2-one
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 072250
Product name: 2-Bromo-5-hydroxypyrazine
Purity: 95+%
Packaging: 5g
Price: $69
Updated: 2021/12/16

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2-Bromo-5-hydroxypyrazine Chemical Properties,Usage,Production

Uses

5-bromo-1H-pyrazin-2-one is a useful research chemical.

Synthesis

59489-71-3

374063-92-0

General procedure for the synthesis of 2-bromo-5-hydroxypyrazine from 2-amino-5-bromopyrazine: sodium nitrite (1.35 g, 19.53 mmol) was added to concentrated sulfuric acid (9.8 mL) in batches at 0 °C. The mixture was heated to 50 °C until the sodium nitrite was completely dissolved and subsequently cooled to 0 °C. A solution of 5-bromo-pyrazin-2-ylamine (2.57 g, 14.68 mmol) in concentrated sulfuric acid (14.7 mL) was added slowly and dropwise. The ice bath was removed and the mixture was gradually warmed to room temperature and stirred for 15 minutes, followed by heating to 45 °C for 7 minutes. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into crushed ice water (100 mL). The pH of the aqueous phase was adjusted to 4 with 20% aqueous sodium hydroxide, followed by extraction with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with water (50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to give 2-bromo-5-hydroxypyrazine (1.88 g, 73% yield) as a yellow solid. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 8.07 (1H, s), 7.62 (1H, d, J=3.0 Hz).

References

[1] Patent: US2005/187266, 2005, A1
[2] Patent: WO2004/92145, 2004, A1. Location in patent: Page 133
[3] Patent: US2010/29650, 2010, A1. Location in patent: Page/Page column 64
[4] Patent: US2005/9838, 2005, A1. Location in patent: Page 150
[5] Journal of Chemical Research, 2005, # 11, p. 747 - 749

2-Bromo-5-hydroxypyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-5-hydroxypyrazine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Bromopyrazin-2-ol 374063-92-0
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2-Bromo-5-hydroxypyrazine 374063-92-0
Price: US $10.00/KG
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-14

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Bromo-5-hydroxypyrazine 374063-92-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

374063-92-0, 2-Bromo-5-hydroxypyrazineRelated Search:

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374063-92-0

C4H3N2OBr

C4H3BrN20

Piperazine series

Building Blocks

Pyrazine

Building Blocks/Intermediates