ChemicalBook > CAS DataBase List > R-afatinib

R-afatinib

Product Name: R-afatinib
CAS No.: 945553-91-3
Chemical Name: R-afatinib
Synonyms: Afatinib-2;Afatinib Enantiomer;afatinib impurities139;AFATINIB CHIRAL IMPURITY;(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-;(R,E)-N-(4-((3-Chloro-4- fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinozolin- 6-yl)-4-(dimethylamino)but-2-enamide;(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetra- hydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino) but-2-enamide;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-;(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide? (Afatinib Impurity）
CBNumber: CB62676100
Molecular Formula: C24H25ClFN5O3
Formula Weight: 485.94
MOL File: 945553-91-3.mol

Less

R-afatinib Property

Boiling point:: 676.9±55.0 °C(Predicted)
Density: 1.380±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 11.79±0.43(Predicted)
color: Pale Beige to Pale Brown
InChIKey: ULXXDDBFHOBEHA-QDLOVBKTSA-N
SMILES: C(NC1C(O[C@@H]2CCOC2)=CC2C(C=1)=C(NC1=CC=C(F)C(Cl)=C1)N=CN=2)(=O)/C=C/CN(C)C

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: C597485
Product name: (R)-Afatinib
Packaging: 25mg
Price: $780
Updated: 2021/12/16

Ambeed

Product number: A334222
Product name: (R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Purity: 99%
Packaging: 100mg
Price: $216
Updated: 2021/12/16

Ambeed

Product number: A334222
Product name: (R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Purity: 99%
Packaging: 250mg
Price: $303
Updated: 2021/12/16

Ambeed

Product number: A334222
Product name: (R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Purity: 99%
Packaging: 1g
Price: $835
Updated: 2021/12/16

A1 Biochem Labs

Product number: 6566856
Product name: AfatinibImpurityC
Purity: 95%
Packaging: 250mg
Price: $1200
Updated: 2021/12/16

Less

R-afatinib Chemical Properties,Usage,Production

Uses

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide, is an impurity of Afatinib (A355300) an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

R-afatinib Preparation Products And Raw materials

Raw materials

Preparation Products

Less

R-afatinib Suppliers

China 71 India 2 United States 4 Global 77

Arizest(Shanghai)Pharmatech Co.,Ltd

Tel: 60753300-53010 13671599112
Email: geshi.zhuang@acebright.com
Country: China
ProdList: 97
Advantage: 58

Suzhou Puster Biotechnology Co., Ltd

Tel: 15001877879
Email: 894058805@qq.com
Country: China
ProdList: 63
Advantage: 58

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shandong Boluoda Biological Technology Co., Ltd.

Tel: 0531-68652053 15863796298;
Email: 2310993908@qq.com
Country: China
ProdList: 2437
Advantage: 58

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-58362220 0086-15250997978
Fax: 025-58362220
Email: sale@njxizebio.com
Country: China
ProdList: 4855
Advantage: 55

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Roark Standards

Tel: 0755-83552066 15986688328
Fax: 0755-83552066
Email: service@roarkstandards.com
Country: China
ProdList: 1442
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

XinYao(Shenzhen) Biological Technology Co., Ltd.

Tel: 0755-89880280
Fax: 0755-89880280
Email: 3004662104@qq.com
Country: China
ProdList: 1829
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Wuhan Yingpuri Pharmaceutical Technology Co. Ltd.

Tel: 17312123985
Email: hero102012020@126.com
Country: CHINA
ProdList: 52
Advantage: 58

Jiangsu aikang biomedical research and development co., LTD

Tel: 025-58859352 13155353615
Email: qzhang@aikonchem.com
Country: China
ProdList: 15525
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7924
Advantage: 58

Jinan Baizhou Biological Technology Co., Ltd.

Tel: 0531-88987162 18615427082
Email: 2823799053@qq.com
Country: China
ProdList: 544
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Hangzhou Huarong Pharm Co., Ltd.

Tel: 571-86758373 +8613588754946
Fax: 0086-571-81131109
Email: sales@huarongpharm.com
Country: CHINA
ProdList: 3148
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 020-36607679 19925672674
Fax: QQ 3008233717
Email: 3008233746@qq.com
Country: China
ProdList: 9883
Advantage: 12

Jinan blalong chemical co. LTD

Tel: 2710913286@.com
Email: 1513643261@qq.com
Country: China
ProdList: 14246
Advantage: 58

Shanghai Payne Pharmaceutical Technology Co.Ltd

Tel: 021-58123769 17721400256
Email: info@paynepharm.com
Country: China
ProdList: 1285
Advantage: 58

Shanghai Payne Pharmaceutical Technology Co.Ltd

Tel: 021-58123769 18678586262
Email: info@paynepharm.com
Country: China
ProdList: 1354
Advantage: 58

Shenzhen ruikai de biotechnology co., ltd.

Tel: 0755-61348847 17820674378
Fax: 0755-21016893
Email: 2682116078@qq.com
Country: China
ProdList: 7843
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Wuxi Minglu Medicine technology Co.,Ltd.

Tel: 0510-88726693
Fax: 0510-88726693
Email: 3204601684@qq.com
Country: China
ProdList: 2215
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Shandong WorldSun Biological Technology Co., Ltd.

Tel: 0531-88723173 18596073690
Email: 1047208234@qq.com
Country: China
ProdList: 6776
Advantage: 58

SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD

Tel: 0755-0755-83725350 13380397412
Fax: 0755-28094224
Email: 3001280422@qq.com
Country: China
ProdList: 10001
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9208
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4171
Advantage: 58

Guangzhou Juntang Technology Co., Ltd

Tel: 020-36607679 13502246435
Email: sales@dmstandards.com
Country: China
ProdList: 10945
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: +86-0755-66853366 +86-13670046396
Email: export03@qcsrm.com
Country: China
ProdList: 24342
Advantage: 58

Molcoo Chemicals Inc.

Tel: 18576690171
Email: 3001025734@qq.com
Country: China
ProdList: 8880
Advantage: 58

Huaihua Yuanyanda Biotechnology Co., Ltd

Tel: 18711085600
Email: 1652923704@qq.com
Country: China
ProdList: 4628
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Shenzhen Roark Pharma-Tec Co., Ltd.

Tel: 13128912434
Email: 2880126944@qq.com
Country: China
ProdList: 3100
Advantage: 58

Scinova Biotech(Guangzhou) Co., Ltd.

Tel: 13268215580
Email: scinova_sales@163.com
Country: China
ProdList: 7025
Advantage: 58

Heze Aiding Pharmaceutical Co., Ltd

Tel: 17661365138
Email: 2845578351@qq.com
Country: China
ProdList: 7115
Advantage: 58

Shenzhen Excellent Biomedical Technology Co., Ltd.

Tel: 0755-26050679 18318671572
Email: 2850803126@qq.com
Country: China
ProdList: 10001
Advantage: 58

Shanghai Zerui Biotechnology Co., Ltd.

Tel: 021-54580889 18321124657
Fax: 021-54580889
Email: 731997554@qq.com
Country: China
ProdList: 10608
Advantage: 58

Huanuo Pharmaceutical Technology (Guangxi) Co., Ltd

Tel: 13005928603
Email: 211017228@qq.com
Country: China
ProdList: 8277
Advantage: 58

Shenzhen Qingtian Biotechnology Co, Ltd.

Tel: 18823167005 18162969855
Email: 744288988@qq.com
Country: China
ProdList: 2629
Advantage: 58

ShenZhen H&D Pharmaceutical Technology Co., LTD

Tel: 18126517264
Email: 2850476883@qq.com
Country: China
ProdList: 7994
Advantage: 58

Less

View Lastest Price from R-afatinib manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Afatinib impurity C 945553-91-3
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-05

Career Henan Chemical Co

Product: R-afatinib 945553-91-3
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

945553-91-3, R-afatinibRelated Search:

Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine Afatinib iMpurity 4-Hydroxy 4-Dedimethylamino Afatinib Afatinib-d6 TRANS-4-AMINOCROTONIC ACID Afatinib impurity 33 Afatinib impurity 40 Afatinib Impurity 74 Afatinib IMpurity H Afatinib Impurity L (Afatinib N-Oxide) Afatinib Impurity 22 Afatinib impurity 30 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Afatinib impurity 27 Afatinib impurity 34 Afatinib impurity 41

2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetra- hydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino) but-2-enamide

(R,E)-N-(4-((3-Chloro-4- fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinozolin- 6-yl)-4-(dimethylamino)but-2-enamide

Afatinib impurity 3/R-afatinib/(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

Afatinib-2

Afatinib Enantiomer

(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide

2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-

AFATINIB CHIRAL IMPURITY

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide? (Afatinib Impurity）

afatinib impurities139

945553-91-3