7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine

Product Name: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine
CAS No.: 179552-73-9
Chemical Name: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine
Synonyms: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazol;4-(3-Chloro-4-fluoro phenylamino)-7-chloro-6-nitro-quinazoline;N-(3-Chloro-4-fluorophenyl)-7-chloro-6-nitro-4-quinazolinaMine;7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine;7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine;7-CHLORO-N-(3-CHLORO-4-FLUOROPHENYL)-6-NITRO-4-QUINAZOLONAMINE;7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinami...;4-Quinazolinamine, 7-chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-;7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine(179552-73-9)
CBNumber: CB72522084
Molecular Formula: C14H7Cl2FN4O2
Formula Weight: 353.14
MOL File: 179552-73-9.mol

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7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine Property

Boiling point:: 503.3±50.0 °C(Predicted)
Density: 1.634
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 5.07±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC96982
Product name: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine
Packaging: 5G
Price: $80.3
Updated: 2021/12/16

AK Scientific

Product number: Y1297
Product name: 7-chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine
Packaging: 5g
Price: $118
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC96982
Product name: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine
Packaging: 10g
Price: $123.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC96982
Product name: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine
Packaging: 25g
Price: $237.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC96982
Product name: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine
Packaging: 50g
Price: $327.5
Updated: 2021/12/16

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7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine Chemical Properties,Usage,Production

Uses

Nitrogen-containing heterocyclic compounds are the most abundant and integral scaffolds that occurs ubiquitously in a variety of synthetic drugs, bioactive natural products, pharmaceuticals and argrochemicals.

Synthesis

367-21-5

53449-15-3

53449-14-2

179552-73-9

1) A mixture of 7-chloro-6-nitro-3H-quinazolin-4-one (approx. 3:1 ratio, 52.0 g; for preparation, see Leonard et al. J. Org. Chem. 1975, 40, 356-363) was added to thionyl chloride (200 mL) along with DMF (0.7 mL) and heated to reflux for 4 hr. Upon completion of the reaction, the mixture was concentrated to dryness, added toluene (150 mL) and concentrated again. This concentration step was repeated twice, after which dichloromethane (280 mL) was added to the residue with stirring at room temperature. 2) Isopropanol solution (760 mL) of 3-chloro-4-fluoroaniline (36.9 g, 253.6 mmol) was added slowly and dropwise to the above suspension, followed by the addition of methylene chloride (300 mL), and stirred at 20°C for 20 minutes. 3) Under cooling in an ice bath, hexane (600 mL) was added to the mixture and stirring was continued at 20°C. The precipitate was collected by filtration, washed with hexane (200 mL x 2) and dried under reduced pressure. 4) The resulting solid was suspended in a solvent mixture of methanol (1 L) and water (120 mL), and triethylamine (30 mL) was added slowly under cooling in an ice bath. After stirring for 1 hour at room temperature, the precipitate was collected by filtration and washed with water (700mL×2). (5) The crude product (65 g) was washed with acetonitrile (1.2 L) suspended under heating conditions and filtered to obtain the target compound 7-chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-aminoquinazoline (54.6 g, 67% yield).

References

[1] Patent: US2004/116422, 2004, A1. Location in patent: Page/Page column 30

7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine Suppliers

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View Lastest Price from 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine manufacturers

Wuhan Boyuan Import & Export Co., LTD

Product: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazol 179552-73-9
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000tons
Release date: 2023-08-10

Weijer International Trade (Hebei) Co., Ltd

Product: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine 179552-73-9
Price: US $80.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 20tons
Release date: 2023-03-14

Anhui Rencheng Technology Co., Ltd

Product: 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine 179552-73-9
Price: US $10.00/KG
Min. Order: 0.5KG
Purity: >99%
Supply Ability: 20tons
Release date: 2020-12-28

179552-73-9, 7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amineRelated Search:

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7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazolin-4-amine

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7-CHLORO-N-(3-CHLORO-4-FLUOROPHENYL)-6-NITRO-4-QUINAZOLONAMINE

7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinami...

7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitroquinazol

179552-73-9

C14H7Cl2FN4O2