(1R,2S,3S)-Aprepitant

Product Name: (1R,2S,3S)-Aprepitant
CAS No.: 172822-28-5
Chemical Name: (1R,2S,3S)-Aprepitant
Synonyms: SM001F;(2S,3S,1’R)-Aprepitant;Aretetan Impurity-(RSS);Aprepitant (R,S,S)-Isomer;Aprepitant Impurity - (RSS);(R,S,S)-Enantiomer Aprepitant;Aprepitant Impurity 6(R,S,S-Isomer);Aprepitant Intermediate Impurity -(RSS);Aprepitant impurity 7/(1R,2S,3S)-Aprepitant;5-([(2S,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one
CBNumber: CB23146512
Molecular Formula: C23H21F7N4O3
Formula Weight: 534.43
MOL File: 172822-28-5.mol

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(1R,2S,3S)-Aprepitant Property

Density: 1.51±0.1 g/cm3(Predicted)
pka: 8.06±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A729770
Product name: (2S,3S,1’R)-Aprepitant
Packaging: 25mg
Price: $2365
Updated: 2021/12/16

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(1R,2S,3S)-Aprepitant Chemical Properties,Usage,Production

Uses

(2S,3S,1’R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. (2S,3S,1’R)-Aprepitant is also a useful synthetic intermediate in the synthesis of morpholine tachykinin receptor antagonist prodrugs.

(1R,2S,3S)-Aprepitant Preparation Products And Raw materials

Raw materials

Preparation Products

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(1R,2S,3S)-Aprepitant Suppliers

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172822-28-5, (1R,2S,3S)-AprepitantRelated Search:

Aprepitant 5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Benzyl dihydrogen phosphate (2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Aprepitant Impurity 19 [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine Fosaprepitant Impurity 6 Aprepitant ent-Aprepitant (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Aprepitant 1,1,1-Trimethoxy-2-chloroethane Aprepitant Defluoro Aprepitant Aprepitant Impurity B HCl Aprepitant Impurity 11 HCl Aprepitant Impurity 2

Aprepitant Impurity - (RSS)

Aprepitant Intermediate Impurity -(RSS)

Aprepitant impurity 7/(1R,2S,3S)-Aprepitant

Aprepitant Impurity 6(R,S,S-Isomer)

(R,S,S)-Enantiomer Aprepitant

Aprepitant (R,S,S)-Isomer

Aretetan Impurity-(RSS)

5-([(2S,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one

3H-1,2,4-Triazol-3-one, 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, [2S-[2α(S*),3β]]- (9CI)

SM001F

(2S,3S,1’R)-Aprepitant

3H-1,2,4-Triazol-3-one, 5-[[(2S,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-

172822-28-5