(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
- Product Name
- (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
- CAS No.
- 314771-76-1
- Chemical Name
- (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
- Synonyms
- Afatinib-1;Afatinib INT;Afatinib IMpurity B;afatinib impurities140;Afatinib intermediate D;Intermediates of sunitinib;Afatinib Impurity 1 ABCDEFGHJKL;3-furanyl]oxy]-4,6-quinazolinediamine;Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl;N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]
- CBNumber
- CB72617898
- Molecular Formula
- C18H16ClFN4O2
- Formula Weight
- 374.8
- MOL File
- 314771-76-1.mol
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Property
- Boiling point:
- 559.0±50.0 °C(Predicted)
- Density
- 1.473±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated, Heated)
- pka
- 5.89±0.30(Predicted)
- form
- Solid
- color
- Light Yellow to Light Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A355320
- Product name
- Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl(Contained~8.5%Ethanol)
- Packaging
- 10g
- Price
- $870
- Updated
- 2021/12/16
- Product number
- P000545777
- Product name
- (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $8
- Updated
- 2021/12/16
- Product number
- P000545777
- Product name
- (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- Purity
- 98%
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- P000545777
- Product name
- (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- Purity
- 98%
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- P000545777
- Product name
- (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
- Purity
- 98%
- Packaging
- 10g
- Price
- $159
- Updated
- 2021/12/16
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Chemical Properties,Usage,Production
Uses
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
To a solution of 4-(3-chloro-4-fluorophenyl)amino-6-nitro-7-[[(S)-tetrahydro-3-furanyl]oxy]- quinazoline (1.34 g, 3.31 mmol) and ammonium chloride (496 mg, 9.27 mmol) in anhydrous DMF (22 mL), Raney nickel [1.5 mL, 50 % (w/v) in water] was added to the reaction mixture and stirred under an atmosphere of hydrogen at 40 °C for 2 h. After 2 h the reaction was diluted with EtOH (10 mL), filtered through diatomaceous earth and washed with a large excess of EtOH. The residue was concentrated under reduced pressure and purified by column chromatography eluting with CHCl3/MeOH (95:5) to give 6 as a viscous brown oil (950 mg, 77 %).
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine manufacturers
- Product
- N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine 314771-76-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20mt
- Release date
- 2019-03-28
- Product
- N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine 314771-76-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-20
- Product
- Afatinib impurity B 314771-76-1
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-06-05