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(S)-(+)-3-Hydroxytetrahydrofuran

Product Name
(S)-(+)-3-Hydroxytetrahydrofuran
CAS No.
86087-23-2
Chemical Name
(S)-(+)-3-Hydroxytetrahydrofuran
Synonyms
(S)-TETRAHYDROFURAN-3-OL;(S)-3-HYDROXYTETRAHYDROFURAN;(3S)-oxolan-3-ol;(3S)-Tetrahydrofuran-3-ol;(S)-(-)-3-HYDROXY TETRAHYDRO FURAN;Oxolane-3β-ol;(S)-Hydroxy THF;Afatinib intermediate;S-3- Hydroxytetrafuran;Afatinib intermediate B
CBNumber
CB2142463
Molecular Formula
C4H8O2
Formula Weight
88.11
MOL File
86087-23-2.mol
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(S)-(+)-3-Hydroxytetrahydrofuran Property

Boiling point:
80 °C/15 mmHg (lit.)
alpha 
18.5 º (c=2 MeOH)
Density 
1.103 g/mL at 25 °C (lit.)
vapor pressure 
47Pa at 25℃
refractive index 
n20/D 1.45(lit.)
Flash point:
175 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform, Methanol (Slightly)
pka
14.49±0.20(Predicted)
form 
Liquid
Specific Gravity
1.11
color 
Clear colorless to pale yellow
optical activity
[α]20/D +17.5°, c = 2.4 in methanol
Water Solubility 
soluble
BRN 
4652609
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
XDPCNPCKDGQBAN-BYPYZUCNSA-N
LogP
-0.784 at 22℃ and pH6.8
Surface tension
72mN/m at 1g/L and 25℃
CAS DataBase Reference
86087-23-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
RIDADR 
NA 1993 / PGIII
WGK Germany 
3
HS Code 
29321900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
296686
Product name
(S)-(+)-3-Hydroxytetrahydrofuran
Purity
99%
Packaging
5g
Price
$25.52
Updated
2024/03/01
Sigma-Aldrich
Product number
296686
Product name
(S)-(+)-3-Hydroxytetrahydrofuran
Purity
99%
Packaging
25g
Price
$104
Updated
2024/03/01
TCI Chemical
Product number
T1716
Product name
(S)-3-Hydroxytetrahydrofuran
Purity
>98.0%(GC)
Packaging
1g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
T1716
Product name
(S)-3-Hydroxytetrahydrofuran
Purity
>98.0%(GC)
Packaging
5g
Price
$38
Updated
2024/03/01
Alfa Aesar
Product number
H56476
Product name
(S)-(+)-3-Hydroxytetrahydrofuran, 98%
Packaging
5g
Price
$77.65
Updated
2024/03/01
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(S)-(+)-3-Hydroxytetrahydrofuran Chemical Properties,Usage,Production

Description

(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.

Chemical Properties

Colourless Liquid

Uses

(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.

Uses

(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.

Synthesis

(S)-(+)-3-Hydroxytetrahydrofuran was prepared from the reaction of (S)-1,2,4-butanetriol under hydrochloric acid modified montmorillonite catalyst. The steps were as follows：To the heatable reactor (with stirring device), 100g (S)-1,2,4-butanetriol, 200mL toluene, 15g hydrochloric acid modified montmorillonite catalyst prepared in were added successively. The reaction was stopped after 4 h at 110°C. After the reaction is finished, it is naturally cooled to room temperature, and the obtained material is filtered to recover the catalyst. After collecting the filtrate, the remaining solvent and by-product water in the filtrate are distilled off to obtain (S)-3-hydroxytetrahydrofuran crude product. Quantitative analysis was carried out by gas chromatography, and the yield was 96.8%. Finally, the (S)-3-hydroxytetrahydrofuran was obtained by rectification and purification.

(S)-(+)-3-Hydroxytetrahydrofuran Preparation Products And Raw materials

Raw materials

L-Malic acid p-Toluenesulfonic acid Ethanol Toluene Tetrahydrofuran Ethyl acetate Lithium Aluminum Hydride Methanol

Preparation Products

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(S)-(+)-3-Hydroxytetrahydrofuran Suppliers

Australia 1 Belgium 2 Canada 4 China 574 Czech Republic 1 Europe 1 France 1 Germany 9 India 53 Japan 9 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 14 United States 54 Global 728
Shanghai Rochi Pharmaceutical Co., Ltd.
Tel
021-38751876 15000076078
Fax
021-50275764
Email
Info@rochipharma.com
Country
China
ProdList
568
Advantage
55
Shanghai Arbor Chemical Co., Ltd.
Tel
021-60451683 15021268886
Fax
+86-21-60451682
Email
sales@arborchemical.com
Country
China
ProdList
853
Advantage
55
Anhui Dali Biotechnology Co. , Ltd.
Tel
15705632007
Fax
0563-6601666
Email
3383822427@qq.com
Country
China
ProdList
389
Advantage
58
Shanghai Bioman Pharma Limited
Tel
21-33738120 15000110506
Fax
021-23025272
Email
info@bioman.com.cn
Country
China
ProdList
61
Advantage
62
Tai Zhou World Pharm & Chem Co., Ltd
Tel
0576-85301198 13736201658
Email
16029347@qq.com
Country
China
ProdList
104
Advantage
58
Zhejiang Aobang Pharmaceutical & Chemical Co. LTD
Tel
13676682222 13676682222
Email
877870302@qq.com
Country
China
ProdList
28
Advantage
58
Porton Pharma Solutions Ltd.
Tel
23-86083200-6540
Fax
023860832006830
Email
jia.chen@portonpharma.com
Country
China
ProdList
56
Advantage
58
Chongqing Longsheng Pharmaceutical Co., Ltd
Tel
17791355738
Email
sales@cqlonghoo.com
Country
China
ProdList
82
Advantage
58
Shanghai Shenghua Pharmaceutical Technology Co., LTD. (Custom Synthesis Laboratory)
Tel
15901636993
Email
455096425@qq.com
Country
China
ProdList
173
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
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View Lastest Price from (S)-(+)-3-Hydroxytetrahydrofuran manufacturers

Nanjing Fred Technology Co., Ltd
Product
(s)-(+)-3-hydroxytetrahydrofuran 86087-23-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
(S)-(+)-3-Hydroxytetrahydrofuran 86087-23-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99% GC
Supply Ability
100kg
Release date
2021-08-11
Suzhou Nordica Biopharma CO.,LTD
Product
(S)-(+)-3-Hydroxytetrahydrofuran 86087-23-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2024-11-14

86087-23-2, (S)-(+)-3-HydroxytetrahydrofuranRelated Search:

Tetrahydrofuran 2-Methyltetrahydrofuran 3-(S)-HYDROXY TETRAHYDROFURAN 3-HYDROXYTETRAHYDROFURAN 99%,3-HYDROXYTETRAHYDROFURAN (RS)-3-Hydroxytetrahydrofuran POLY(TETRAHYDROFURAN) STANDARD 15000 (R)-(+)-3-HYDROXYTETRAHYDROFURAN-2-ONE α-D-erythro-Pentofuranose-2-deoxy-2,2-difluoro-3,5-dibenzoate (S)-4-HYDROXYTETRAHYDROFURAN-2-ONE,4(S)-Hydroxytetrahydrofuran-2-ONE 3-HYDROXYTETRAHYDROFURAN-2-ONE,2-Hydroxytetrahydrofuran-2-one (R)-(-)-3-HYDROXYTETRAHYDROFURAN,(R)-3-HYDROXYTETRAHYDROFURAN ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate (S)-(+)-3-HYDROXYTETRAHYDROFURAN-D4 (3R)-3β,4α-Bis(3-methoxy-4-hydroxybenzyl)-3-hydroxytetrahydrofuran-2-one (2R, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL (2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL (2S, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL 4-HYDROXYTETRAHYDROFURAN-2-METHANOL

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  • 86087-23-2
  • 86087-23-3
  • ALCOHOL
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  • Heterocyclic Building Blocks
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  • Asymmetric Synthesis
  • Afatinib intermediate
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  • Simple Alcohols (Chiral)
  • Synthetic Organic Chemistry