(S)-(+)-3-Hydroxytetrahydrofuran
- Product Name
- (S)-(+)-3-Hydroxytetrahydrofuran
- CAS No.
- 86087-23-2
- Chemical Name
- (S)-(+)-3-Hydroxytetrahydrofuran
- Synonyms
- (S)-TETRAHYDROFURAN-3-OL;(S)-3-HYDROXYTETRAHYDROFURAN;(3S)-oxolan-3-ol;(3S)-Tetrahydrofuran-3-ol;(S)-(-)-3-HYDROXY TETRAHYDRO FURAN;Oxolane-3β-ol;(S)-Hydroxy THF;Afatinib intermediate;S-3- Hydroxytetrafuran;Afatinib intermediate B
- CBNumber
- CB2142463
- Molecular Formula
- C4H8O2
- Formula Weight
- 88.11
- MOL File
- 86087-23-2.mol
(S)-(+)-3-Hydroxytetrahydrofuran Property
- Boiling point:
- 80 °C/15 mmHg (lit.)
- alpha
- 18.5 º (c=2 MeOH)
- Density
- 1.103 g/mL at 25 °C (lit.)
- vapor pressure
- 47Pa at 25℃
- refractive index
- n20/D 1.45(lit.)
- Flash point:
- 175 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol (Slightly)
- pka
- 14.49±0.20(Predicted)
- form
- Liquid
- Specific Gravity
- 1.11
- color
- Clear colorless to pale yellow
- optical activity
- [α]20/D +17.5°, c = 2.4 in methanol
- Water Solubility
- soluble
- BRN
- 4652609
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- InChIKey
- XDPCNPCKDGQBAN-BYPYZUCNSA-N
- LogP
- -0.784 at 22℃ and pH6.8
- Surface tension
- 72mN/m at 1g/L and 25℃
- CAS DataBase Reference
- 86087-23-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 296686
- Product name
- (S)-(+)-3-Hydroxytetrahydrofuran
- Purity
- 99%
- Packaging
- 5g
- Price
- $25.52
- Updated
- 2024/03/01
- Product number
- 296686
- Product name
- (S)-(+)-3-Hydroxytetrahydrofuran
- Purity
- 99%
- Packaging
- 25g
- Price
- $104
- Updated
- 2024/03/01
- Product number
- T1716
- Product name
- (S)-3-Hydroxytetrahydrofuran
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $16
- Updated
- 2024/03/01
- Product number
- T1716
- Product name
- (S)-3-Hydroxytetrahydrofuran
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $38
- Updated
- 2024/03/01
- Product number
- H56476
- Product name
- (S)-(+)-3-Hydroxytetrahydrofuran, 98%
- Packaging
- 5g
- Price
- $77.65
- Updated
- 2024/03/01
(S)-(+)-3-Hydroxytetrahydrofuran Chemical Properties,Usage,Production
Description
(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.
Chemical Properties
Colourless Liquid
Uses
(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.
Uses
(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.
Synthesis
(S)-(+)-3-Hydroxytetrahydrofuran was prepared from the reaction of (S)-1,2,4-butanetriol under hydrochloric acid modified montmorillonite catalyst. The steps were as follows：To the heatable reactor (with stirring device), 100g (S)-1,2,4-butanetriol, 200mL toluene, 15g hydrochloric acid modified montmorillonite catalyst prepared in were added successively. The reaction was stopped after 4 h at 110°C. After the reaction is finished, it is naturally cooled to room temperature, and the obtained material is filtered to recover the catalyst. After collecting the filtrate, the remaining solvent and by-product water in the filtrate are distilled off to obtain (S)-3-hydroxytetrahydrofuran crude product. Quantitative analysis was carried out by gas chromatography, and the yield was 96.8%. Finally, the (S)-3-hydroxytetrahydrofuran was obtained by rectification and purification.
(S)-(+)-3-Hydroxytetrahydrofuran Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-(+)-3-Hydroxytetrahydrofuran Suppliers
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View Lastest Price from (S)-(+)-3-Hydroxytetrahydrofuran manufacturers
- Product
- (s)-(+)-3-hydroxytetrahydrofuran 86087-23-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-20
- Product
- (S)-(+)-3-Hydroxytetrahydrofuran 86087-23-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99% GC
- Supply Ability
- 100kg
- Release date
- 2021-08-11
- Product
- (S)-(+)-3-Hydroxytetrahydrofuran 86087-23-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2024-11-14