ChemicalBook > CAS DataBase List > (S)-(+)-3-Hydroxytetrahydrofuran

(S)-(+)-3-Hydroxytetrahydrofuran

Product Name
(S)-(+)-3-Hydroxytetrahydrofuran
CAS No.
86087-23-2
Chemical Name
(S)-(+)-3-Hydroxytetrahydrofuran
Synonyms
(S)-TETRAHYDROFURAN-3-OL;(S)-3-HYDROXYTETRAHYDROFURAN;(3S)-oxolan-3-ol;(3S)-Tetrahydrofuran-3-ol;(S)-(-)-3-HYDROXY TETRAHYDRO FURAN;Oxolane-3β-ol;(S)-Hydroxy THF;Afatinib intermediate;S-3- Hydroxytetrafuran;Afatinib intermediate B
CBNumber
CB2142463
Molecular Formula
C4H8O2
Formula Weight
88.11
MOL File
86087-23-2.mol
More
Less

(S)-(+)-3-Hydroxytetrahydrofuran Property

Boiling point:
80 °C/15 mmHg (lit.)
alpha 
18.5 º (c=2 MeOH)
Density 
1.103 g/mL at 25 °C (lit.)
vapor pressure 
47Pa at 25℃
refractive index 
n20/D 1.45(lit.)
Flash point:
175 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform, Methanol (Slightly)
pka
14.49±0.20(Predicted)
form 
Liquid
Specific Gravity
1.11
color 
Clear colorless to pale yellow
optical activity
[α]20/D +17.5°, c = 2.4 in methanol
Water Solubility 
soluble
BRN 
4652609
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
XDPCNPCKDGQBAN-BYPYZUCNSA-N
LogP
-0.784 at 22℃ and pH6.8
Surface tension
72mN/m at 1g/L and 25℃
CAS DataBase Reference
86087-23-2(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
RIDADR 
NA 1993 / PGIII
WGK Germany 
3
HS Code 
29321900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
296686
Product name
(S)-(+)-3-Hydroxytetrahydrofuran
Purity
99%
Packaging
5g
Price
$25.52
Updated
2024/03/01
Sigma-Aldrich
Product number
296686
Product name
(S)-(+)-3-Hydroxytetrahydrofuran
Purity
99%
Packaging
25g
Price
$104
Updated
2024/03/01
TCI Chemical
Product number
T1716
Product name
(S)-3-Hydroxytetrahydrofuran
Purity
>98.0%(GC)
Packaging
1g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
T1716
Product name
(S)-3-Hydroxytetrahydrofuran
Purity
>98.0%(GC)
Packaging
5g
Price
$38
Updated
2024/03/01
Alfa Aesar
Product number
H56476
Product name
(S)-(+)-3-Hydroxytetrahydrofuran, 98%
Packaging
5g
Price
$77.65
Updated
2024/03/01
More
Less

(S)-(+)-3-Hydroxytetrahydrofuran Chemical Properties,Usage,Production

Description

(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.

Chemical Properties

Colourless Liquid

Uses

(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.

Uses

(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.

Synthesis

(S)-(+)-3-Hydroxytetrahydrofuran was prepared from the reaction of (S)-1,2,4-butanetriol under hydrochloric acid modified montmorillonite catalyst. The steps were as follows：To the heatable reactor (with stirring device), 100g (S)-1,2,4-butanetriol, 200mL toluene, 15g hydrochloric acid modified montmorillonite catalyst prepared in were added successively. The reaction was stopped after 4 h at 110°C. After the reaction is finished, it is naturally cooled to room temperature, and the obtained material is filtered to recover the catalyst. After collecting the filtrate, the remaining solvent and by-product water in the filtrate are distilled off to obtain (S)-3-hydroxytetrahydrofuran crude product. Quantitative analysis was carried out by gas chromatography, and the yield was 96.8%. Finally, the (S)-3-hydroxytetrahydrofuran was obtained by rectification and purification.

(S)-(+)-3-Hydroxytetrahydrofuran Preparation Products And Raw materials

Raw materials

L-Malic acid p-Toluenesulfonic acid Ethanol Toluene Tetrahydrofuran Ethyl acetate Lithium Aluminum Hydride Methanol

Preparation Products

More
Less

(S)-(+)-3-Hydroxytetrahydrofuran Suppliers

Australia 1 Belgium 2 Canada 4 China 574 Czech Republic 1 Europe 1 France 1 Germany 9 India 53 Japan 9 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 14 United States 54 Global 728
Shanghai Rochi Pharmaceutical Co., Ltd.
Tel
021-38751876 15000076078
Fax
021-50275764
Email
Info@rochipharma.com
Country
China
ProdList
568
Advantage
55
Shanghai Arbor Chemical Co., Ltd.
Tel
021-60451683 15021268886
Fax
+86-21-60451682
Email
sales@arborchemical.com
Country
China
ProdList
853
Advantage
55
Anhui Dali Biotechnology Co. , Ltd.
Tel
15705632007
Fax
0563-6601666
Email
3383822427@qq.com
Country
China
ProdList
389
Advantage
58
Shanghai Bioman Pharma Limited
Tel
21-33738120 15000110506
Fax
021-23025272
Email
info@bioman.com.cn
Country
China
ProdList
61
Advantage
62
Tai Zhou World Pharm & Chem Co., Ltd
Tel
0576-85301198 13736201658
Email
16029347@qq.com
Country
China
ProdList
104
Advantage
58
Zhejiang Aobang Pharmaceutical & Chemical Co. LTD
Tel
13676682222 13676682222
Email
877870302@qq.com
Country
China
ProdList
28
Advantage
58
Porton Pharma Solutions Ltd.
Tel
23-86083200-6540
Fax
023860832006830
Email
jia.chen@portonpharma.com
Country
China
ProdList
56
Advantage
58
Chongqing Longsheng Pharmaceutical Co., Ltd
Tel
17791355738
Email
sales@cqlonghoo.com
Country
China
ProdList
82
Advantage
58
Shanghai Shenghua Pharmaceutical Technology Co., LTD. (Custom Synthesis Laboratory)
Tel
15901636993
Email
455096425@qq.com
Country
China
ProdList
173
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Suzhou Chireach Biomedical Technology Co., Ltd.
Tel
0512-65856968
Fax
0512-65647218
Email
sales@chireach.com
Country
China
ProdList
59
Advantage
70
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Shanghai Scientia Pharmaceutical Technology Co., Ltd.
Tel
21-21-54301573 13917723525
Fax
(86)21-51861981
Email
sales@scientiapharm.com
Country
China
ProdList
263
Advantage
62
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376090521
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
979
Advantage
60
Suzhou Zehou Biotechnology Co. , Ltd.
Tel
0512-68716880 18075373931
Fax
18075373931
Email
sales@growingchem.com
Country
China
ProdList
191
Advantage
64
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Anhui Lianchuang Biological Medicine Co.,Ltd
Tel
0551-68779238 18056025720
Email
sales3@lcywhx.com
Country
China
ProdList
158
Advantage
57
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
PSN Pharmaceutical Technology Co., Ltd.
Tel
86-25-57062118
Fax
86-25-57065896
Email
sales@jspsn.com
Country
China
ProdList
496
Advantage
57
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Tel
0512-68780025 18962125825
Email
sales@ryanchem.com
Country
China
ProdList
163
Advantage
62
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7191
Advantage
65
Z IntellecChem& Tech. Co., Ltd
Tel
15050866711
Fax
QQ:2677337387
Email
saleszchem@163.com
Country
China
ProdList
110
Advantage
62
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
Advantage
57
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1931
Advantage
57
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
971
Advantage
62
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3203
Advantage
55
Shanghai Sphchem Co., Ltd.
Tel
21-21-56491756 13512199871
Fax
021-5649-1756
Email
sales@panhongchem.com
Country
China
ProdList
3999
Advantage
55
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2872
Advantage
58
Changzhou Joyous Chemical Co., Ltd.
Tel
0519-85607258
Fax
0519-85607278
Email
sales@joyouschem.com
Country
China
ProdList
294
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
684
Advantage
58
More
Less

View Lastest Price from (S)-(+)-3-Hydroxytetrahydrofuran manufacturers

Nanjing Fred Technology Co., Ltd
Product
(s)-(+)-3-hydroxytetrahydrofuran 86087-23-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
(S)-(+)-3-Hydroxytetrahydrofuran 86087-23-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99% GC
Supply Ability
100kg
Release date
2021-08-11
Suzhou Nordica Biopharma CO.,LTD
Product
(S)-(+)-3-Hydroxytetrahydrofuran 86087-23-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2024-11-14

86087-23-2, (S)-(+)-3-HydroxytetrahydrofuranRelated Search:

Tetrahydrofuran 2-Methyltetrahydrofuran 3-(S)-HYDROXY TETRAHYDROFURAN 3-HYDROXYTETRAHYDROFURAN 99%,3-HYDROXYTETRAHYDROFURAN (RS)-3-Hydroxytetrahydrofuran POLY(TETRAHYDROFURAN) STANDARD 15000 (R)-(+)-3-HYDROXYTETRAHYDROFURAN-2-ONE α-D-erythro-Pentofuranose-2-deoxy-2,2-difluoro-3,5-dibenzoate (S)-4-HYDROXYTETRAHYDROFURAN-2-ONE,4(S)-Hydroxytetrahydrofuran-2-ONE 3-HYDROXYTETRAHYDROFURAN-2-ONE,2-Hydroxytetrahydrofuran-2-one (R)-(-)-3-HYDROXYTETRAHYDROFURAN,(R)-3-HYDROXYTETRAHYDROFURAN ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate (S)-(+)-3-HYDROXYTETRAHYDROFURAN-D4 (3R)-3β,4α-Bis(3-methoxy-4-hydroxybenzyl)-3-hydroxytetrahydrofuran-2-one (2R, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL (2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL (2S, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL 4-HYDROXYTETRAHYDROFURAN-2-METHANOL

  • (S)-TETRAHYDROFURAN-3-OL
  • (S)-(+)-TETRAHYDRO-3-FURANOL
  • (S)-(+)-3-HYDROXY TETAHYDRO FURAN
  • (S)-(-)-3-HYDROXY TETRAHYDRO FURAN
  • (3S)-oxolan-3-ol
  • (2S)-1,4-Epoxy-2-hydroxybutane, (3S)-Tetrahydrofuran-3-ol, (3S)-Oxolan-3-ol
  • Afatinib intermediate B
  • (S)-(+)-3-Hydroxytetrahydrofuran, ee: 95%
  • Afatinib intermediate
  • (S)-(+)-3-HydroxytetrahydrofuranZ
  • (S)-(+)-3-Hydroxytetrahydrofuran 99%
  • (S)-(+)-3-Hydroxytetrahydrofuran, 98% colorless liquid
  • (S)-(+)-3-Hydroxytetrahydrofuran, 98%, ee: 95%
  • (S)-(+)-3-HYDROXYTETRAHYDROFURAN
  • (S)-3-HYDROXYTETRAHYDROFURAN
  • (S)-(+)-3-HYDROXYTETRAHYDROFURANE
  • 3-FURANOL, TETRAHYDRO-, (S)
  • (S)-(+)-3-HYDROXYTETRAHYDROFURAN, 99% (9
  • S-(+)-3-HYDROXYTETRAHYDROFURAN 98+%
  • (S)-(+)-3-HYDOXY TETAHYDRO TETRAHYDRO FURAN
  • (S)-3-Hydroxyterthydrofurane
  • S-HYDROXYTETRAHYDROFURAN
  • S-(+)-3-Hydroxytetrahydofuran
  • (3S)-Tetrahydrofuran-3-ol
  • (3S)-Tetrahydrofuran-3β-ol
  • Oxolane-3β-ol
  • (S)-(+)-3-Hydroxytetrahydrofuran,99%
  • (S)-(+)-tetrahyro-3-furanol
  • (S)-(+)-3-Hydroxytetrahydrofuran ,98% [ee:95%]
  • (2S)-2-Hydroxy-1,4-epoxybutane
  • (3S)-3-Hydroxytetrahydrofuran
  • (3S)-(+)-3-Hydroxytetrahydrofuran 97+%
  • (S)-(+)-3-HYDROXYTETRAHYDROFURAN, (9
  • (S)-(+)-3-Hydroxy-1,2,3,4-tetrahydrofuran
  • S-3-hydroxytetrahydrofur
  • (S)-3-hydroxytetyrahydrofurane
  • S-3- Hydroxytetrafuran
  • 3-Furanol, tetrahydro-, (3S)-
  • (S)-(+)-3-HYDROXYTETRAHYDROFURAN (CAS NO.86087-23-2)
  • (S)-Hydroxy THF
  • (3S)-Tetrahydrofuran-3-ol,(3S)-Oxolan-3-ol
  • (+)-3-Hydroxy-1,2,3,4-Tetrahydrofuran
  • Empagliflozin Impurity 100
  • (S)-3-hydroxytetyrahydrofuran
  • (+)-3-Hydroxytetrahydrofuran
  • 2,4-Dichlorobenzyl Alcohol Impurity 10
  • 86087-23-2
  • 86087-23-3
  • ALCOHOL
  • Simple Alcohols (Chiral)
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Furans
  • Asymmetric Synthesis
  • Afatinib intermediate
  • Chiral Building Blocks
  • Simple Alcohols (Chiral)
  • Synthetic Organic Chemistry