(R)-(-)-3-Hydroxytetrahydrofuran

Product Name: (R)-(-)-3-Hydroxytetrahydrofuran
CAS No.: 86087-24-3
Chemical Name: (R)-(-)-3-Hydroxytetrahydrofuran
Synonyms: (R)-3-HYDROXYTETRAHYDROFURAN;(3R)-oxolan-3-ol;(3R)-Tetrahydrofuran-3-ol;(R)-TETRAHYDROFURAN-3-OL;Empagliflozin Impurity 67;(3R)-Tetrahydrofuran-3α-ol;Empagliflozin Impurity 149;3-FURANOL, TETRAHYDRO-, (R);(R)-(-)-TETRAHYDRO-3-FURANOL;3-Furanol, tetrahydro-,(3R)-
CBNumber: CB8310051
Molecular Formula: C4H8O2
Formula Weight: 88.11
MOL File: 86087-24-3.mol

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(R)-(-)-3-Hydroxytetrahydrofuran Property

alpha: -18.5 º (c=2 MeOH)
Boiling point:: 181 °C (lit.)
Density: 1.097 g/mL at 25 °C (lit.)
refractive index: n20/D 1.45(lit.)
Flash point:: 180 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform, Methanol (Slightly)
form: Liquid
pka: 14.49±0.20(Predicted)
color: Clear colorless
Specific Gravity: 1.097
optical activity: [α]20/D 18°, c = 2.4 in methanol
InChI: InChI=1S/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2/t4-/m1/s1
InChIKey: XDPCNPCKDGQBAN-SCSAIBSYSA-N
SMILES: O1CC[C@@H](O)C1
CAS DataBase Reference: 86087-24-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: NA 1993 / PGIII
WGK Germany: 3
HazardClass: CBL
HS Code: 29321900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 309753
Product name: (R)-(?)-3-Hydroxytetrahydrofuran
Purity: 98%
Packaging: 1g
Price: $32.2
Updated: 2025/07/31

TCI Chemical

Product number: H1332
Product name: (R)-3-Hydroxytetrahydrofuran
Purity: >98.0%(GC)
Packaging: 1g
Price: $81
Updated: 2025/07/31

TCI Chemical

Product number: H1332
Product name: (R)-3-Hydroxytetrahydrofuran
Purity: >98.0%(GC)
Packaging: 5g
Price: $281
Updated: 2025/07/31

TRC

Product number: H957760
Product name: (R)-(-)-3-Hydroxytetrahydrofuran
Packaging: 1g
Price: $80
Updated: 2021/12/16

TRC

Product number: H957760
Product name: (R)-(-)-3-Hydroxytetrahydrofuran
Packaging: 25g
Price: $640
Updated: 2021/12/16

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(R)-(-)-3-Hydroxytetrahydrofuran Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-(-)-3-Hydroxytetrahydrofuran is used as a chemical reactant in the synthesis of pharmaceutical agents. Empagliflozin is synthesized using this reactant

Uses

(R)-(-)-3-Hydroxytetrahydrofuran may be used as building block in the synthesis of potent HIV protease inhibitors.

Synthesis

125605-10-9

86087-24-3

Example 5 Preparation of (R)-3-hydroxytetrahydrofuran: 35 g (0.28 mol) of (R)-4-chloro-1,3-butanediol made in reference to Example 2 was dissolved in 70 mL of 0.5 N hydrochloric acid solution and the reaction was heated under reflux conditions for 2 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was neutralized with 50% aqueous sodium hydroxide solution, followed by evaporation under reduced pressure to remove water. To the residual crystals and oily mixture, 60 mL of methanol was added and mixed with thorough stirring. Insoluble crystals were removed by filtration and the filtrate was concentrated under reduced pressure. Finally, the concentrated residue was distilled under reduced pressure to give 16.6 g of (R)-(-)-3-hydroxytetrahydrofuran in the form of colorless liquid (purity: 99.1%; yield: 67%). Its rotundity was determined as [α]D23 = -15.91° (c = 2.45, methanol).

References

[1] Patent: US5780649, 1998, A
[2] Patent: WO2008/93955, 2008, A1. Location in patent: Paragraph 65-66
[3] Patent: WO2016/21192, 2016, A1. Location in patent: Paragraph 0085

(R)-(-)-3-Hydroxytetrahydrofuran Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-3-Hydroxytetrahydrofuran Suppliers

Americas 1 Canada 2 China 293 Europe 1 France 1 Germany 8 India 27 Japan 3 South Korea 3 Switzerland 1 United Kingdom 6 United States 38 Global 384

Shanghai Rochi Pharmaceutical Co., Ltd.

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Shanghai Longsheng chemical Co.,Ltd.

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Jiangxi Zhiyan Biopharmaceutical Technology Co., Ltd

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Hangzhou WDJBIO Co., Ltd.

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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
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View Lastest Price from (R)-(-)-3-Hydroxytetrahydrofuran manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: (R)-(-)-3-Hydroxytetrahydrofuran 86087-24-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99% GC
Supply Ability: 100kg
Release date: 2021-08-11

Hebei Chuanghai Biotechnology Co., Ltd

Product: (R)-(-)-3-Hydroxytetrahydrofuran 86087-24-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: (R)-(-)-3-Hydroxytetrahydrofuran 86087-24-3
Price: US $200.00-85.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-23

86087-24-3, (R)-(-)-3-HydroxytetrahydrofuranRelated Search:

2-Methyltetrahydrofuran Tetrahydrofuran 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Acetoxy Empagliflozin (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran (3R,4S,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)-2-methoxyoxane-3,4,5-triol EMpagliflozin iMpurity 10 Butanoic acid, 4-chloro-3-hydroxy-, (3S)- Methanone, (5-chloro-2-iodophenyl)(2-fluorophenyl)- (5-bromo-2-chlorophenyl)(4-fluorophenyl)methanone 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)benzyl]benzene Empagliflozin Impurity 32 4-(pyridine-2-yl) pyrimidin-2-amine (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone EMpagliflozin iMpurity 13 Empagliflozin Impurity

(R)-(-)-TETRAHYDRO-3-FURANOL

(R)-(-)-3-HYDROXYTETRAHYDROFURAN

(R)-3-HYDROXYTETRAHYDROFURAN

(R)-(-)-3-HYDROXYTETRAHYDROFURANE

3-FURANOL, TETRAHYDRO-, (R)

(R)-TETRAHYDROFURAN-3-OL

(3R)-Tetrahydrofuran-3-ol

(3R)-Tetrahydrofuran-3α-ol

(R)-(-)-3-Hydoxy tetahydrotetrahydrofuran

(3R)-3-Hydroxytetrahydrofuran

3-Furanol, tetrahydro-,(3R)-

(3R)-oxolan-3-ol

Empagliflozin Impurity 67

(R)-3-hydroxytetyrahydrofurane

(R)-(-)-3-Hydroxytetrahydrofur

(R)-(-)-3-Hydroxytetrahydrofuran 98%

(R)-Tetrahydrofuran-3-ol(Rotation(-))

(R)-3-Hydroxytetrahydrofuran&gt

Empagliflozin Impurity 149

(-)-3-Hydroxytetrahydrofuran

(R)-(-)-3-Hydroxytetrahydrof

(<i>R</i>)-(?)-3-Hydroxytetrahydrofuran

86087-24-3

6087-24-3

Asymmetric Synthesis

Chiral Building Blocks

Furans

Heterocyclic Building Blocks

Furans

Building Blocks for HIV Protease InhibitorsChiral Building Blocks

Cell Signaling Enzymes

Heterocyclic Building Blocks

HIV Protease Reagents&Envelope Proteins

Alcohols, Hydroxy Esters and Derivatives

Chiral Compounds

chiral

Tetrahydrofuran Series

ADVANCED INT.