ChemicalBook > CAS DataBase List > (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Product Name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
CAS No.
915095-86-2
Chemical Name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Synonyms
Englenet Impurity 16;Empagliflozin Impurity 48;2-chloro-4-fluoro-5-Iodobenzophenon;2-Chloro-4'-fluoro-5-iodobenzophenone;2-Chloro-4'-fluoro-5-iodobenzophenone;Empagliflozin Impurity 48 /Englenet Impurity 16;(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone;Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
CBNumber
CB12651407
Molecular Formula
C13H7ClFIO
Formula Weight
360.55
MOL File
915095-86-2.mol
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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Property

Melting point:
64-70℃
Boiling point:
415℃
Density 
1.752
Flash point:
205℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Ethyl Acetate
form 
Solid
color 
Off-White
InChI
InChI=1S/C13H7ClFIO/c14-12-6-5-10(16)7-11(12)13(17)8-1-3-9(15)4-2-8/h1-7H
InChIKey
KNYGUQLVFSPVRI-UHFFFAOYSA-N
SMILES
C(C1=CC(I)=CC=C1Cl)(C1=CC=C(F)C=C1)=O
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Safety

Safety Statements 
24/25
HS Code 
29142990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368575
Product name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Packaging
2.5g
Price
$595
Updated
2021/12/16
AK Scientific
Product number
9597AF
Product name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Packaging
100g
Price
$605
Updated
2021/12/16
Apolloscientific
Product number
PC540099
Product name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Purity
98%
Packaging
100g
Price
$634
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
91537
Product name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Packaging
1g
Price
$725
Updated
2021/12/16
Apolloscientific
Product number
PC540099
Product name
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Purity
98%
Packaging
25g
Price
$224
Updated
2021/12/16
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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Chemical Properties,Usage,Production

Uses

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is a reagent in the synthesis of Empagliflozin (E521510); an inhibitor of SGLT-2.

Synthesis

5-Iodo-2-chlorobenzoic acid (20.0 g, 0.071 mol) was added to a solution of 2.0 M oxalyl chloride in dichloromethane (39 ml, 0.078 mol), stirred for suspension, and then 8 drops of DMF solution was added dropwise. The solution was clarified after the reaction was carried out for 3 hours. The solvent was spin-dried on a rotary evaporator, and then 15 ml of methylene chloride was added. After spin-drying, add 30 ml of dichloromethane, stir, cool to 0-5 ° C, add fluorobenzene (7. lg, 0.074 mol), add anhydrous aluminum trichloride (9.9 g, 0.074 mol) in batches, control The temperature is not more than 5 °C, after the completion of the addition, stirring is continued at 4 ° C for 1 h, the reaction is quenched on the ice-water mixture, the organic phase is separated, and the aqueous phase is extracted with dichloromethane. The phase was washed twice with 1 mol/L hydrochloric acid, once with water, and twice with 1 mol/L NaOH solution. The mixture was washed twice with saturated sodium chloride and dried over anhydrous sodium sulfate. Drain filtration, spin dry solvent to obtain oil after column chromatography, 20. 1g (78.6percent) of a white solid (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone was obtained.

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Suppliers

China 210 India 9 United Kingdom 1 United States 8 Global 228
Carbott PharmTech Inc.
Tel
0535-6385396
Fax
+86 (535) 638-9971
Email
info@carbottpharm.com
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China
ProdList
917
Advantage
56
Suzhou Xiaoli Material Technology Co., Ltd.
Tel
0512-87815088 18015562287
Fax
0512-69233866
Email
xmwang@xiaolitech.com
Country
China
ProdList
68
Advantage
58
Chongqing Ensky Pharmaceutical Co.,Ltd.
Tel
023-86815286 13983794297
Fax
+86-23-86815116
Email
sales@ensky-chemical.com
Country
China
ProdList
91
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HSDK（Nanjing）Pharma Tech Co.，Ltd.
Tel
15189849794
Email
xiaojin.wu@hsdk-pharmatech.cn
Country
China
ProdList
25
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58
EVERSHINE CHEMICAL CO., LIMITED
Tel
0571-58120272 17185714011
Email
3506894070@qq.com
Country
China
ProdList
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58
Beijing Stronger Science Co., Ltd.
Tel
0531-88924771 15614660963
Email
elsa.hang@strongerscience.com
Country
China
ProdList
10623
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58
Beijing Huikang Boyuan Chemical Tech Co., Ltd
Tel
010-68862197 13810598707
Fax
010-68882204
Email
sales@huikangchem.com
Country
China
ProdList
103
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61
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
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55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
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61
Suzhou Zehou Biotechnology Co. , Ltd.
Tel
0512-68716880 19984816880
Fax
18075373931
Email
sales@growingchem.com
Country
China
ProdList
192
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64
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View Lastest Price from (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone manufacturers

Suzhou Nordica Biopharma CO.,LTD
Product
2-Chloro-4'-fluoro-5-iodobenzophenone 915095-86-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
5 tons
Release date
2024-11-14
Hebei Yanxi Chemical Co., Ltd.
Product
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08
Shanghai Joiny Pharmaceutical Co.,LTD
Product
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500k
Release date
2023-09-08

915095-86-2, (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanoneRelated Search:

Acetoxy Empagliflozin Empagliflozin Impurity 23 Empagliflozin (R)-Isomer ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate N/A Butanoic acid, 4-chloro-3-hydroxy-, (3S)- (4R,5R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl) phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol (3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol 4-CHLORO-2-FLUOROIODOBENZENE DIPHENYLENEIODONIUM CHLORIDE (S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran

  • (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
  • Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
  • (2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone
  • Empagliflozin Impurity 48
  • Englenet Impurity 16
  • 2-chloro-4-fluoro-5-Iodobenzophenon
  • (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon
  • 2-Chloro-4'-fluoro-5-iodobenzophenone
  • (2-Chloro-5-iodine phenyl) 4-fluorophenyl) methylone
  • Empagliflozin Impurity 48 /Englenet Impurity 16
  • 2-Chloro-4'-fluoro-5-iodobenzophenone
  • 915095-86-2
  • 945065-86-2
  • C13H7ClFIO